Search Results - "Gonda, T."

Role and potential for therapeutic targeting of MYB in leukemia by Pattabiraman, D R, Gonda, T J

“…The Myb protein was first identified as an oncogene that causes leukemia in chickens. Since then, it has been widely associated with different types of cancers…”
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PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models by Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I

“…Background: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix…”
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Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells by Peters, A A, Jamaludin, S Y N, Yapa, K T D S, Chalmers, S, Wiegmans, A P, Lim, H F, Milevskiy, M J G, Azimi, I, Davis, F M, Northwood, K S, Pera, E, Marcial, D L, Dray, E, Waterhouse, N J, Cabot, P J, Gonda, T J, Kenny, P A, Brown, M A, Khanna, K K, Roberts-Thomson, S J, Monteith, G R

“…The critical role of calcium signalling in processes related to cancer cell proliferation and invasion has seen a focus on pharmacological inhibition of…”
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The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1 by Zhao, L, Ye, P, Gonda, T J

“…The MYB gene is a master regulator of hematopoiesis and contributes to leukemogenesis in several species including humans. Although it is clear that MYB can…”
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Reinforcement in removable prosthodontics: a literature review by Takahashi, T., Gonda, T., Mizuno, Y., Fujinami, Y., Maeda, Y.

“…Summary Removable prosthodontics are often associated with mechanical troubles in daily use, such as fracture or deformation. These troubles render prostheses…”
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The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy by Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V., Bytheway, I.

“…Summary Heparan sulfate mimetics, which we have called the PG500 series, have been developed to target the inhibition of both angiogenesis and heparanase…”
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Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells by Jamaludin, S Y N, Azimi, I, Davis, F M, Peters, A A, Gonda, T J, Thompson, E W, Roberts-Thomson, S J, Monteith, G R

“…CXC ligand (L)12 is a chemokine implicated in the migration, invasion and metastasis of cancer cells via interaction with its receptors CXC chemokine receptor…”
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Effect of Reinforcement on Overdenture Strain by Gonda, T., Ikebe, K., Dong, J., Nokubi, T.

“…Because the abutment becomes the fulcrum, and the denture base over the coping is usually thin, the overdenture is susceptible to fracture. We hypothesized…”
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Five-year multicenter study of magnetic attachments used for natural overdenture abutments by Gonda, T., Yang, T. C., Maeda, Y.

“…Summary The purpose of this study was to examine a longitudinal clinical performance of magnetic attachments used for natural overdenture abutments. The study…”
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Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry by Smith, M S, Cash, B, Konda, V, Trindade, A J, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, U D, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, J A, Sejpal, D V, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, Chang, K

“…Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center…”
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A family of cytokine-inducible inhibitors of signalling by Hilton, Douglas J, Starr, Robyn, Willson, Tracy A, Viney, Elizabeth M, Murray, Leecia J. L, Rayner, John R, Jenkins, Brendan J, Gonda, Thomas J, Alexander, Warren S, Metcalf, Donald, Nicola, Nicos A

“…Cytokines are secreted proteins that regulate important cellular responses such as proliferation and differentiation. Key events in cytokine signal…”
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A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability by Sæther, T, Pattabiraman, D R, Alm-Kristiansen, A H, Vogt-Kielland, L T, Gonda, T J, Gabrielsen, O S

“…c-Myb is an essential hematopoietic transcription factor that controls proliferation and differentiation of progenitors during blood cell development. Whereas…”
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Endoscopic Evaluation in Patients with CF-LVADs with Gastrointestinal Bleeding: Are We Ready for a Paradigm Shift to Improve Care? by Axelrad, J, Pinsino, A, Brooks, C, Trinh, P, Cagliostro, B, Castagna, F, Topkara, V.K, Garan, A.R, Effner, L.A, Takayama, H, Takeda, K, Naka, Y, Colombo, P.C, Yuzefpolskaya, M, Gonda, T

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Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling by Ciznadija, D, Tothill, R, Waterman, M L, Zhao, L, Huynh, D, Yu, R M, Ernst, M, Ishii, S, Mantamadiotis, T, Gonda, T J, Ramsay, R G, Malaterre, J

“…Aberrant Wnt signaling mediated by mutations affecting APC (adenomatous polyposis coli) or β -catenin initiates the majority of human colorectal cancers (CRC)…”
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294 Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer by Gabrielli, B, Bokhari, F, Ranall, M, Stevenson, A, Murell, M, Kelly, M, McKee, S, Leggatt, G, Gonda, T, McMillan, N

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Repression of Gadd45α by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation by Perugini, M, Kok, C H, Brown, A L, Wilkinson, C R, Salerno, D G, Young, S M, Diakiw, S M, Lewis, I D, Gonda, T J, D'Andrea, R J

“…The tumor suppressor Gadd45α was earlier shown to be a repressed target of sustained receptor-mediated ERK1/2 signaling. We have identified Gadd45α as a…”
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Influence of abutment height on strain in a mandibular overdenture by DONG, J., IKEBE, K., GONDA, T., NOKUBI, T.

“…summary  The purpose of this study was to investigate the influence of coping heights on the strain around the abutment teeth and at the middle part of…”
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Association of symptomless TMJ sounds with occlusal force and masticatory performance in older adults by IKEBE, K., HAZEYAMA, T., IWASE, K., SAJIMA, H., GONDA, T., MAEDA, Y., NOKUBI, T.

“…Summary  This study investigated associations between temporomandibular joint (TMJ) sounds and occlusal force or masticatory performance stratified by…”
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Development of an RPD CAD system with finite element stress analysis by KIBI, M., ONO, T., DONG, J., MITTA, K., GONDA, T., MAEDA, Y.

“…Summary  The structural design of removable partial dentures (RPDs) is critical for preventing distortion of the prosthesis, protecting abutment teeth and…”
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Functional expression cloning reveals proapoptotic role for protein phosphatase 4 by Mourtada-Maarabouni, M, Kirkham, L, Jenkins, B, Rayner, J, Gonda, T J, Starr, R, Trayner, I, Farzaneh, F, Williams, G T

“…Functional expression cloning strategies are highly suitable for the analysis of the molecular control of apoptosis. This approach has two critical advantages…”
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