Search Results - "Gonda, Hiroyuki"

Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs by Katakai, Tomoya, Suto, Hidenori, Sugai, Manabu, Gonda, Hiroyuki, Togawa, Atsushi, Suematsu, Sachiko, Ebisuno, Yukihiko, Katagiri, Koko, Kinashi, Tatsuo, Shimizu, Akira

“…Mesenchymal stromal cells are crucial components of secondary lymphoid organs (SLOs). Organogenesis of SLOs involves specialized stromal cells, designated…”
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Roles of p-ERM and Rho-ROCK Signaling in Lymphocyte Polarity and Uropod Formation by Lee, Jong-Hwan, Katakai, Tomoya, Hara, Takahiro, Gonda, Hiroyuki, Sugai, Manabu, Shimizu, Akira

“…Front-rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which…”
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A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells by Katakai, Tomoya, Hara, Takahiro, Lee, Jong-Hwan, Gonda, Hiroyuki, Sugai, Manabu, Shimizu, Akira

“…For efficient adaptive immunity, the lymph nodes (LNs) are equipped with a strategically organized microarchitecture, which is largely supported by the…”
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The balance between Pax5 and Id2 activities is the key to AID gene expression by Gonda, Hiroyuki, Sugai, Manabu, Nambu, Yukiko, Katakai, Tomoya, Agata, Yasutoshi, Mori, Kazuhiro J, Yokota, Yoshifumi, Shimizu, Akira

“…Pax5 activity is enhanced in activated B cells and is essential for class switch recombination (CSR). We show that inhibitor of differentiation (Id)2…”
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Essential role of Id2 in negative regulation of IgE class switching by Shimizu, Akira, Sugai, Manabu, Gonda, Hiroyuki, Kusunoki, Takashi, Katakai, Tomoya, Yokota, Yoshifumi

“…Serum concentrations of immunoglobulin E (IgE) in normal circumstances are kept much lower than those of other Ig isotypes to avoid allergic reactions. B cells…”
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A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion by Hara, Takahiro, Katakai, Tomoya, Lee, Jong-Hwan, Nambu, Yukiko, Nakajima-Nagata, Natsuki, Gonda, Hiroyuki, Sugai, Manabu, Shimizu, Akira

“…Stromal cells in lymphoid tissues provide microenvironmental fields required for the triggering of efficient immune responses. Fibroblastic reticular cells…”
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Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse by Katakai, Tomoya, Nomura, Takashi, Gonda, Hiroyuki, Sugai, Manabu, Agata, Yasutoshi, Nishio, Akiyoshi, Masuda, Tohru, Sakaguchi, Shimon, Shimizu, Akira

“…Autoimmunity is often accompanied by the development of ectopic lymphoid tissues in the target organ, and these tissues have been believed to have close…”
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Th1-Biased Tertiary Lymphoid Tissue Supported by CXC Chemokine Ligand 13-Producing Stromal Network in Chronic Lesions of Autoimmune Gastritis by Katakai, Tomoya, Hara, Takahiro, Sugai, Manabu, Gonda, Hiroyuki, Shimizu, Akira

“…Secondary lymphoid tissue is developmentally programmed and characterized by well-ordered compartmentalization of lymphocyte subsets and specialized stromal…”
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Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies by SUGAI, Manabu, GONDA, Hiroyuki, NAMBU, Yukiko, YOKOTA, Yoshifumi, SHIMIZU, Akira

“…Id (inhibitor of differentiation) proteins play important roles in cell differentiation, cell cycle control, and apoptosis. They act as negative regulators of…”
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Chemokine-independent Preference for T-helper-1 Cells in Transendothelial Migration by Katakai, Tomoya, Hara, Takahiro, Sugai, Manabu, Gonda, Hiroyuki, Nambu, Yukiko, Matsuda, Eishou, Agata, Yasutoshi, Shimizu, Akira

“…We analyzed differences in the transendothelial migration (TEM) ability of T-helper (Th)-1 and Th2 cells across a murine endothelial cell line (F-2) under…”
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Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes by Katakai, Tomoya, Hara, Takahiro, Sugai, Manabu, Gonda, Hiroyuki, Shimizu, Akira

“…The sophisticated microarchitecture of the lymph node, which is largely supported by a reticular network of fibroblastic reticular cells (FRCs) and…”
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Targeting of Krüppel-associated Box-containing Zinc Finger Proteins to Centromeric Heterochromatin by Matsuda, Eishou, Agata, Yasutoshi, Sugai, Manabu, Katakai, Tomoya, Gonda, Hiroyuki, Shimizu, Akira

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Accessibility Control of Recombination at Immunoglobulin Locus by Sugai, Manabu, Gonda, Hiroyuki, Nambu, Yukiko, Yokota, Yoshifumi, Shimizu, Akira

“…During B cell development, two somatic DNA recombination events occur at the immunoglobulin heavy chain loci: VDJ recombination and class switch recombination…”
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Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin by Nambu, Yukiko, Sugai, Manabu, Gonda, Hiroyuki, Lee, Chung-Gi, Katakai, Tomoya, Agata, Yasutoshi, Yokota, Yoshifumi, Shimizu, Akira

“…Class switch recombination (CSR) at the antibody immunoglobulin locus is regulated by germline transcription (GLT)-coupled modifications in the accessibility…”
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Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination by Agata, Y, Katakai, T, Ye, S K, Sugai, M, Gonda, H, Honjo, T, Ikuta, K, Shimizu, A

“…Variable/diversity/joining (V[D]J) recombination of the T cell receptor (TCR) and immunoglobulin (Ig) genes is regulated by chromatin accessibility of the…”
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Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms by Matsuda, E, Agata, Y, Sugai, M, Katakai, T, Gonda, H, Shimizu, A

“…Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs) repress transcription via functional interaction with the corepressor KRAB-associated…”
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Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H super(+)/K super(+)-ATPase-Reactive TCR Transgenic Mouse by Katakai, Tomoya, Nomura, Takashi, Gonda, Hiroyuki, Sugai, Manabu, Agata, Yasutoshi, Nishio, Akiyoshi, Masuda, Tohru, Sakaguchi, Shimon, Shimizu, Akira

“…Autoimmunity is often accompanied by the development of ectopic lymphoid tissues in the target organ, and these tissues have been believed to have close…”
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CpG inhibits IgE class switch recombination through suppression of NFκB activity, but not through Id2 or Bcl6 by Kusunoki, Takashi, Sugai, Manabu, Gonda, Hiroyuki, Nambu, Yukiko, Nagata-Nakajima, Natsuki, Katakai, Tomoya, Kusunoki, Mariko, Sakamoto, Akemi, Tokuhisa, Takeshi, Nakahata, Tatsutoshi, Yokota, Yoshifumi, Shimizu, Akira

“…The CpG motif in DNA plays a critical role in immunity via modulating the Th1/Th2 balance. In B cells, CpG-containing oligodeoxynucleotides (CpG ODNs) inhibit…”
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Targeting of Krüppel-associated Box-containing Zinc Finger Proteins to Centromeric Heterochromatin by Eishou Matsuda, Yasutoshi Agata, Manabu Sugai, Tomoya Katakai, Hiroyuki Gonda, Akira Shimizu

“…Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs) repress transcription via functional interaction with the corepressor KRAB-associated…”
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HB-1, an acute myeloid leukemic cell line with the capability of infiltrating into the brain in CBA/N mice by Jiang, Hui-Jie, Sun, Hu-Shan, Wang, Xu-Dong, Wang, Chang-Liu, Liu, Ze-Long, Gonda, Hiroyuki, Sugimoto, Kenkichi

“…An acute myeloid leukemic HB-1 cell line was cloned and established from the spleen cells of irradiated CBA/N mice. Acute myeloma leukemia-like syndrome would…”
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