Search Results - "Goncz, K K"

Limited Restoration of Cystic Fibrosis Lung Epithelium In Vivo with Adult Bone Marrow-derived Cells by Loi, Roberto, Beckett, Travis, Goncz, Kaarin K, Suratt, Benjamin T, Weiss, Daniel J

“…Recent literature suggests that adult bone marrow-derived cells can localize to lung and acquire immunophenotypic characteristics of lung epithelial cells. We…”
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Isolation of CF cell lines corrected at Δf508-CFTR locus by SFHR-mediated targeting by BRUSCIA, E, SANGIUOLO, F, SINIBALDI, P, GONCZ, K. K, NOVELLI, G, GRUENERT, D. C

“…Cystic fibrosis is the most common inherited disease in the Caucasian population. About 70% of all CF chromosomes carry the ΔF508 mutation, a 3-bp deletion…”
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Targeted Replacement of Normal and Mutant CFTR Sequences in Human Airway Epithelial Cells Using DNA Fragments by Goncz, Kaarin K., Kunzelmann, Karl, Xu, Zhidong, Gruenert, Dieter C.

“…Recent studies have reported that mutant genomic cystic fibrosis (CF) transmembrane conductance regulator (CFTR) sequences can be corrected in transformed CF…”
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Application of SFHR to gene therapy of monogenic disorders by GONCZ, K. K, PROKOPISHYN, N. L, CHOW, B. L, DAVIS, B. R, GRUENERT, D. C

“…Gene therapy treatment of disease will be greatly facilitated by the identification of genetic mutations through the Human Genome Project. The specific…”
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Sequence-specific modification of genomic DNA by small DNA fragments by Gruenert, Dieter C, Bruscia, Emanuela, Novelli, Giuseppe, Colosimo, Alessia, Dallapiccola, Bruno, Sangiuolo, Federica, Goncz, Kaarin K

“…Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic…”
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Transfer and expression of foreign genes in mammalian cells by Colosimo, A, Goncz, K K, Holmes, A R, Kunzelmann, K, Novelli, G, Malone, R W, Bennett, M J, Gruenert, D C

“…The transfer of foreign genes into eukaryotic cells, in particular mammalian cells, has been essential to our understanding of the functional significance of…”
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Expression of Δf508 CFTR in normal mouse lung after site-specific modification of CFTR sequences by SFHR by GONCZ, K. K, COLOSIMO, A, XU, Z, GRUENERT, D. C, DALLAPICCOLA, B, GAGNE, L, HONG, K, NOVELLI, G, PAPAHADJOPOULOS, D, SAWA, T, SCHREIER, H, WIENER-KRONISH, J

“…The development of gene targeting strategies for specific modification of genomic DNA in human somatic cells has provided a potential gene therapy for the…”
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Targeted Correction of a Defective Selectable Marker Gene in Human Epithelial Cells by Small DNA Fragments by Colosimo, Alessia, Goncz, Kaarin K., Novelli, Giuseppe, Dallapiccola, Bruno, Gruenert, Dieter C.

“…A novel gene targeting strategy, small fragment homologous replacement (SFHR), has been used to correct specific genomic lesions in human epithelial cells. The…”
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Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow by Beckett, Travis, Loi, Roberto, Prenovitz, Robert, Poynter, Matthew, Goncz, Kaarin K, Suratt, Benjamin T, Weiss, Daniel J

“…Adult marrow-derived stem cells can localize to lung and acquire immunophenotypic characteristics of lung epithelial cells. Lung injury increases recruitment…”
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Differential sensitivity of normal and cystic fibrosis airway epithelial cells to epinephrine by Goncz, Kaarin K, Feeney, Luz, Gruenert, Dieter C

“…Exposure to epinephrine has been shown to have a range of effects on cells and tissues. A recent study suggested that the proliferative ability of CF…”
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Intracellular compartmentalization of DNA fragments in cultured airway epithelial cells mediated by cationic lipids by HOLMES, A. R, DOHRMAN, A. F, ELLISON, A. R, GONCZ, K. K, GRUENERT, D. C

“…The amount and intracellular distribution of DNA fragments (491-bp) was characterized after transfection in vitro with a commercially available cationic lipid…”
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Site-directed alteration of genomic DNA by small-fragment homologous replacement by Goncz, K K, Gruenert, D C

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Dual Y chromosome painting and in situ cell-specific immunofluorescence staining in lung tissue: an improved method of identifying donor marrow cells in lung following bone marrow transplantation by Trotman, Winifred, Beckett, Travis, Goncz, Kaarin K, Beatty, Barbara G, Weiss, Daniel J

“…Several recent studies have demonstrated localization of donor bone marrow-derived cells in recipient lungs following transplantation from male to female mice…”
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Sequence-specific modification of genomic DNA by small DNA fragments by Gruenert, Dieter C., Bruscia, Emanuela, Novelli, Giuseppe, Colosimo, Alessia, Dallapiccola, Bruno, Sangiuolo, Federica, Goncz, Kaarin K.

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A trans-membrane pore can account for protein movement across zymogen granule membranes by Goncz, Kaarin K., Rothman, Stephen S.

“…We have reported that the membrane of zymogen granules, secretion vesicles from the exocrine pancreas, is permeable to its contained proteins by measuring both…”
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The protein content and morphogenesis of zymogen granules by Goncz, K K, Behrsing, R, Rothman, S S

“…When zymogen granules, the secretion granules of pancreatic acinar cells, fill, secretory product is accumulated in immature granules, condensing vacuoles…”
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Protein flux across the membrane of single secretion granules by Goncz, K K, Rothman, S S

“…We have applied, for the first time to our knowledge, X-ray microscopy to measure the mass of protein contained in single sub-cellular membrane-bound…”
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Construction and purification of pSABR 01, a pUC19-derived vector optimized for cloning full-length cDNA by SEMPRINI, Sabrina, COLLINS, Cheryl C, GONCZ, Kaarin C, NOVELLI, Giuseppe, GRUENERT, Dieter C

“…A novel pUC19-derived vector, pSABR 01, was constructed by sub-cloning a fragment of the pSPORT1 polylinker into PUC19. The insertion of the polylinker…”
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Small fragment homologous replacement-mediated modification of genomic beta-globin sequences in human hematopoietic stem/progenitor cells by Goncz, Kaarin K, Prokopishyn, Nicole L, Abdolmohammadi, Alireza, Bedayat, Babak, Maurisse, Rosalie, Davis, Brian R, Gruenert, Dieter C

“…An ultimate goal of gene therapy is the development of a means to correct mutant genomic sequences in the cells that give rise to pathology. A number of…”
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Application of SFHR to gene therapy of monogenic disorders by Goncz, K K, Prokopishyn, N L, Chow, B L, Davis, B R, Gruenert, D C

“…Gene therapy treatment of disease will be greatly facilitated by the identification of genetic mutations through the Human Genome Project. The specific…”
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