ANALGESIC ACTIVITY OF SOME NEW DECAHYDROQUINOLINE DERIVATIVES.

The work was aimed at assessing in vivo the analgesic properties of ten decahydroquinoline derivatives (pharmacologically active substances, PAS) and deter- mining the role of opioid receptors in mechanism of their action. Among the derivatives studied, pronounced analgesic properties at a dose of 1...

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Bibliographic Details
Published in:Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 79; no. 11; p. 7
Main Authors: Goncharukl, V V, Buben, A L, Borisenok, O A, Kozlovskii, V I, Pun'ko, I M, Vdovichenko, V P, Praliev, K D
Format: Journal Article
Language:Russian
Published: Russia (Federation) 2016
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Summary:The work was aimed at assessing in vivo the analgesic properties of ten decahydroquinoline derivatives (pharmacologically active substances, PAS) and deter- mining the role of opioid receptors in mechanism of their action. Among the derivatives studied, pronounced analgesic properties at a dose of 1/4 LD50 was ob- served for two compounds (PAS-70 and PAS-71), while four compounds (PAS-66, PAS-69, PAS-74, PAS-76) produced weak and short anesthetic effects. PAS-70 and PAS-71 showed analgesic action even in a dose of 1/8 LD50. The maximum effect of PAS-70 and PAS-71 was developed within 20 - 60 min after administration and lasted for two hours (PAS-70 in a dose of 1/4 LD50, PAS-71 in doses of 1/4 and 1/8 LD50). The analgesic effect of PAS-70 (at 1/4 LD5,) and PAS-71 (at 1/4 and 1/8 LD50) significantly exceeds that of reference drugs metamizol (1/4 LD5) and ketorolac (1/4 LD50). The mechanism of drug action is not related to opioid receptors.
ISSN:0869-2092