Pharmacogenetic markers of development of angioneurotic edema as a secondary side effect to enalapril in patients with essential arterial hypertension

Angioneurotic edema is the most dangerous complication in angiotensin-converting enzyme inhibitors (ACEIs) therapy. Based on the current data, the clinical and genetic predictors of angioedema development are still understudied, which demonstrates the relevance of this study. To reveal the pharmacog...

Full description

Saved in:

Bibliographic Details
Published in:	The International journal of risk & safety in medicine Vol. 35; no. 1; p. 37
Main Authors:	Sychev, Ivan V, Denisenko, Natalia P, Kachanova, Anastasiya A, Lapshtaeva, Anna V, Abdullaev, Sherzod P, Goncharova, Ludmila N, Mirzaev, Karin B, Sychev, Dmitry A
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2024
Subjects:	Angioedema - chemically induced Angioedema - genetics Enalapril - adverse effects Essential Hypertension Genotype Humans Liver-Specific Organic Anion Transporter 1 Pharmacogenetics angioedema adverse drug reaction hypertensive disease ACE inhibitors enalapril
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Angioneurotic edema is the most dangerous complication in angiotensin-converting enzyme inhibitors (ACEIs) therapy. Based on the current data, the clinical and genetic predictors of angioedema development are still understudied, which demonstrates the relevance of this study. To reveal the pharmacogenetic predictors of the angioedema as a secondary side effect to enalapril in patients with essential arterial hypertension. The study enrolled 111 subjects randomized into two groups: study group, patients with the angioedema as a secondary side effect to enalapril; and control group, patients without adverse drug reaction. All patients underwent pharmacogenetic testing. An association between the development of the angioneurotic edema and the genotypes AA rs2306283 of gene SLCO1B1, TT rs4459610 of gene ACE, and CC rs1799722 of gene BDKRB2 in patients was revealed. The findings justify further investigations of the revealed genetic predictors of angioedema with larger-size patient populations.
ISSN:	1878-6847
DOI:	10.3233/JRS-230006