Search Results - "Gonatas, Nicholas K"

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death by Gonatas, Nicholas K., Stieber, Anna, Gonatas, Jacqueline O.

“…Fragmentation of the neuronal Golgi apparatus (GA) was reported in amyotrophic lateral sclerosis (ALS), corticobasal degeneration, Alzheimer's and…”
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Thyroid Transcription Factor 1 Expression in Sellar Tumors: A Histogenetic Marker? by Lee, Edward B, Tihan, Tarik, Scheithauer, Bernd W, Zhang, Paul J, Gonatas, Nicholas K

“…Pituicytomas are rare low-grade gliomas of the neurohypophysis. Their morphology and variable immunophenotype have led to speculation that they arise from…”
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The Mitotic Phosphorylation Cycle of the cis-Golgi Matrix Protein GM130 by Lowe, Martin, Gonatas, Nicholas K., Warren, Graham

“…The cis-Golgi matrix protein GM130 is phosphorylated in mitosis on serine 25. Phosphorylation inhibits binding to p115, a vesicle-tethering protein, and has…”
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Autobiography Series by Gonatas, Nicholas K

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Dysregulation of Stathmin, a Microtubule-Destabilizing Protein, and Up-Regulation of Hsp25, Hsp27, and the Antioxidant Peroxiredoxin 6 in a Mouse Model of Familial Amyotrophic Lateral Sclerosis by Strey, Christoph W., Spellman, Daniel, Stieber, Anna, Gonatas, Jacqueline O., Wang, Xiaosong, Lambris, John D., Gonatas, Nicholas K.

“…Gain-of-function mutations of the Cu/Zn superoxide dismutase (SOD1) gene cause dominantly inherited familial amyotrophic lateral sclerosis. The identification…”
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Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis by Ko, Melissa W, Turkeltaub, Peter E, Lee, Edward B, Gonatas, Nicholas K, Volpe, Nicholas J, Moster, Mark L, Galetta, Steven L

“…Abstract Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare, fatal, neoplastic condition of infiltrating glial cells into the meninges without…”
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Masses of phosphorylated neurofilaments are associated with abnormal Golgi apparatus of anterior horn neurons of β, β′-iminodipropionitrile-intoxicated rats by Uesugi, Makoto, Okamoto, Koichi, Tanaka, Makoto, Gonatas, Nicholas K

“…The Golgi apparatus (GA) of anterior horn neurons of rats chronically intoxicated with β,β′‐iminodipropionitrile (IDPN) in drinking water was examined with an…”
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The Golgi Apparatus of Spinal Cord Motor Neurons in Transgenic Mice Expressing Mutant Cu,Zn Superoxide Dismutase Becomes Fragmented in Early, Preclinical Stages of the Disease by Mourelatos, Zissimos, Gonatas, Nicholas K., Stieber, Anna, Gurney, Mark E., Mauro C. Dal Canto

“…Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral…”
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Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt–Jakob disease by Prasad, Sashank, Ko, Melissa W, Lee, Edward B, Gonatas, Nicholas K, Stern, Matthew B, Galetta, Steven

“…Abstract Supranuclear gaze palsies are an uncommon feature of Creutzfeldt–Jakob disease (CJD). Most reported cases of CJD with features of supranuclear gaze…”
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Pathology of the inferior olivary nucleus in patients with multiple system atrophy by SAKURAI, Atsushi, OKAMOTO, Koichi, YAGUCHI, Masamitsu, FUJITA, Yukio, MIZUNO, Yuji, NAKAZATO, Yoichi, GONATAS, Nicholas K

“…The inferior olivary nucleus (ION) from nine patients with multiple system atrophy was examined with antibodies against alpha-synuclein, ubiquitin,…”
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Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus by Stieber, Anna, Gonatas, Jacqueline O, Gonatas, Nicholas K

“…Transgenic mice that express the G93A mutation of human Cu,Zn superoxide dismutase (SOD1 G93A), found in familial amyotrophic lateral sclerosis (FALS), showed…”
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Fragmentation of the Golgi apparatus of the anterior horn cells in patients with familial amyotrophic lateral sclerosis with SOD1 mutations and posterior column involvement by Fujita, Yukio, Okamoto, Koichi, Sakurai, Atsushi, Gonatas, Nicholas K, Hirano, Asao

“…The Golgi apparatus (GA) of the anterior horn cells in the spinal cord was examined by immunohistological methods with an antibody against the MG-160 protein,…”
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The Golgi apparatus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions by FUJITA, Yukio, OKAMOTO, Koichi, SAKURAI, Atsushi, KUSAKA, Hirofumi, AIZAWA, Hitoshi, MIHARA, Ban, GONATAS, Nicholas K

“…The mechanisms of neuronal death in amyotrophic lateral sclerosis (ALS) are not known. A pathological aggregation of cytoplasmic constituents in the form of…”
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The involvement of the neuronal Golgi apparatus and trans-Golgi network in the human olivary hypertrophy by Takamine, Kazuo, Okamoto, Koichi, Fujita, Yukio, Sakurai, Atsushi, Takatama, Masamitsu, Gonatas, Nicholas K.

“…We studied the Golgi apparatus (GA) and trans-Golgi network (TGN) in the human olivary hypertrophy by immunohistological methods with organelle specific…”
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The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene by Stieber, Anna, Gonatas, Jacqueline O, Collard, Jean-Francois, Meier, Jurgen, Julien, Jean-Pierre, Schweitzer, Peter, Gonatas, Nicholas K

“…Fragmentation of the Golgi apparatus (GA) of motor neurons was first described in sporadic amyotrophic lateral sclerosis (ALS) and later confirmed in…”
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Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas by Yamaguchi, Fumio, Morrison, Richard S, Gonatas, Nicholas K, Takahashi, Hiroshi, Sugisaki, Yuichi, Teramoto, Akira

“…Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has…”
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Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1G93A mutation of familial amyotrophic lateral sclerosis by STIEBER, Anna, GONATAS, Jacqueline O, GONATAS, Nicholas K

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MG-160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, binds basic fibroblast growth factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor by Gonatas, J O, Mourelatos, Z, Stieber, A, Lane, W S, Brosius, J, Gonatas, N K

“…We report the primary structure of MG-160, a 160 kDa membrane sialoglycoprotein residing in the medial cisternae of the Golgi apparatus of rat neurons,…”
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Truncations of the C-terminal cytoplasmic domain of MG160, a medial Golgi sialoglycoprotein, result in its partial transport to the plasma membrane and filopodia by Gonatas, J O, Chen, Y J, Stieber, A, Mourelatos, Z, Gonatas, N K

“…MG160, a type I cysteine-rich membrane sialoglycoprotein residing in the medial cisternae of the rat Golgi apparatus, is highly homologous to CFR, a fibroblast…”
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Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus by Mourelatos, Z, Gonatas, J O, Cinato, E, Gonatas, N K

“…The amino acid sequence of MG160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, is more than 90% identical with CFR, a…”
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