Search Results - "Gonatas, N"

In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic by Stieber, A, Mourelatos, Z, Gonatas, NK

“…Recent immunocytochemical and morphometric studies in amyotrophic lateral sclerosis, Alzheimer's disease (AD), and aging indicate that the neuronal Golgi…”
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Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by mutants G93A and G85R of Cu, Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis by Stieber, Anna, Gonatas, J.O., Moore, J.S., Bantly, Andrew, Yim, H.-S., Yim, M.B., Gonatas, N.K.

“…The Golgi apparatus of motor neurons (GA) is fragmented in sporadic amyotrophic lateral sclerosis (ALS), in familial ALS with SOD1 mutations, and in mice that…”
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Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease by SAKURAI, A, OKAMOTO, K, FUJITA, Y, NAKAZATO, Y, WAKABAYASHI, K, TAKAHASHI, H, GONATAS, N. K

“…We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with…”
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The Golgi Apparatus of Spinal Cord Motor Neurons in Transgenic Mice Expressing Mutant Cu,Zn Superoxide Dismutase Becomes Fragmented in Early, Preclinical Stages of the Disease by Mourelatos, Zissimos, Gonatas, Nicholas K., Stieber, Anna, Gurney, Mark E., Mauro C. Dal Canto

“…Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral…”
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The fragmented neuronal Golgi apparatus in amyotrophic lateral sclerosis includes the trans-Golgi-network : functional implications by STIEBER, A, YOUJUN CHEN, SHUANG WEI, MOURELATOS, Z, GONATAS, J, OKAMOTO, K, GONATAS, N. K

“…The Golgi apparatus (GA) of spinal cord motor neurons is fragmented in sporadic amyotrophic lateral sclerosis (ALS), and in asymptomatic and symptomatic…”
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Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus by Stieber, Anna, Gonatas, Jacqueline O, Gonatas, Nicholas K

“…Transgenic mice that express the G93A mutation of human Cu,Zn superoxide dismutase (SOD1 G93A), found in familial amyotrophic lateral sclerosis (FALS), showed…”
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Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis by Gilchrist, C. A., Gray, D. A., Stieber, A., Gonatas, N. K., Kopito, R. R.

“…The ubiquitin‐proteasome system (UPS) is a central component in the cellular defence against potentially toxic protein aggregates. UPS dysfunction is linked to…”
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Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia by Turner, R S, Kenyon, L C, Trojanowski, J Q, Gonatas, N, Grossman, M

“…We report the clinical, neuroimaging, and neuropathologic features of progressive nonfluent aphasia (PNFA), a rare neurodegenerative syndrome most notable for…”
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The involvement of the Golgi apparatus in the pathogenesis of amyotrophic lateral sclerosis, Alzheimer's disease, and ricin intoxication by Gonatas, N K, Gonatas, J O, Stieber, A

“…Several diseases involving a variety of cells and tissues are associated with defective enzymes of the Golgi apparatus (GA). An intact GA of neurons is crucial…”
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Fragmentation of the Golgi apparatus of the anterior horn cells in patients with familial amyotrophic lateral sclerosis with SOD1 mutations and posterior column involvement by Fujita, Yukio, Okamoto, Koichi, Sakurai, Atsushi, Gonatas, Nicholas K, Hirano, Asao

“…The Golgi apparatus (GA) of the anterior horn cells in the spinal cord was examined by immunohistological methods with an antibody against the MG-160 protein,…”
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The Mitotic Phosphorylation Cycle of the cis-Golgi Matrix Protein GM130 by Lowe, Martin, Gonatas, Nicholas K., Warren, Graham

“…The cis-Golgi matrix protein GM130 is phosphorylated in mitosis on serine 25. Phosphorylation inhibits binding to p115, a vesicle-tethering protein, and has…”
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Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus by Salehi, A, Lucassen, P J, Pool, C W, Gonatas, N K, Ravid, R, Swaab, D F

“…In order to study changes in neuronal activity in the nucleus basalis of Meynert in aging and Alzheimer's disease, we applied a polyclonal antibody directed…”
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Decreased activity of hippocampal neurons in Alzheimer's disease is not related to the presence of neurofibrillary tangles by Salehi, A, Ravid, R, Gonatas, N K, Swaab, D F

“…Numerous studies have established the key role of the Golgi apparatus (GA) in post-translational processing, transport and targeting of proteins destined for…”
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The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene by Stieber, Anna, Gonatas, Jacqueline O, Collard, Jean-Francois, Meier, Jurgen, Julien, Jean-Pierre, Schweitzer, Peter, Gonatas, Nicholas K

“…Fragmentation of the Golgi apparatus (GA) of motor neurons was first described in sporadic amyotrophic lateral sclerosis (ALS) and later confirmed in…”
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Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1(G93A) mutation of familial amyotrophic lateral sclerosis by Stieber, A, Gonatas, J O, Gonatas, N K

“…Mice expressing the G93A and other mutations of Cu,Zn superoxide dismutase (SOD1(G93A)) are valid models for the familial form of amyotrophic lateral sclerosis…”
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Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis (ALS). Clinical studies in ALS of Guam and experimental studies in deafferented neurons and in beta,beta'- iminodipropionitrile axonopathy by Mourelatos, Z, Hirano, A, Rosenquist, AC, Gonatas, NK

“…Previous morphological immunoenzymatic studies with organelle-specific antibodies have disclosed an apparent fragmentation of the Golgi apparatus in large…”
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A noninvasive protocol for anterior temporal lobectomy by SPERLIN, M. R, O'CONNOR, M. J, SAYKIN, A. J, PHILLIPS, C. A, MORRELL, M. J, BRIDGMAN, P. A, FRENCH, J. A, GONATAS, N

“…We report the results of a protocol for choosing candidates for temporal lobectomy using a standard battery of objective tests without intracranial electrodes…”
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Fragmentation of the Golgi apparatus of Betz cells in patients with amyotrophic lateral sclerosis by Fujita, Yukio, Okamoto, Koichi, Sakurai, Atsushi, Amari, Masakuni, Nakazato, Yoichi, Gonatas, Nicholas K.

“…The Golgi apparatus (GA) of the large pyramidal motor neurons in the cerebral cortex (Betz cells), was examined in sixteen patients with sporadic amyotrophic…”
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Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis by Gonatas, NK, Stieber, A, Mourelatos, Z, Chen, Y, Gonatas, JO, Appel, SH, Hays, AP, Hickey, WF, Hauw, JJ

“…The Golgi apparatus (complex) is at the center stage of important functions of processing and transport of plasma membrane, lysosomal, and secreted proteins…”
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MG-160. A novel sialoglycoprotein of the medial cisternae of the Golgi apparatus [published eeratum appears in J Biol Chem 1989 Mar 5;264(7):4264] by Gonatas, J O, Mezitis, S G, Stieber, A, Fleischer, B, Gonatas, N K

“…A monoclonal antibody (mAb 10A8), derived from mice immunized with fractions of the Golgi apparatus from rat brain neurons, was exploited to isolate and…”
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