Search Results - "Gonçalves, Reggiani V"
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Effects of subchronic exposure to environmentally relevant concentrations of the herbicide atrazine in the Neotropical fish Astyanax altiparanae
Published in Ecotoxicology and environmental safety (15-01-2021)“…Atrazine (ATZ) is among the most widely used herbicides in the world, and yet it has a potential to contaminate aquatic environments due to pesticide leaching…”
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2
OxInflammation Affects Transdifferentiation to Myofibroblasts, Prolonging Wound Healing in Diabetes: A Systematic Review
Published in International journal of molecular sciences (19-08-2024)“…Skin wounds, primarily in association with type I diabetes mellitus, are a public health problem generating significant health impacts. Therefore, identifying…”
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3
Prolonged testosterone 17β-cyclopentylpropionate exposition induces behavioral, ovarian, oviductal, uterine and reproductive disturbances in female mice
Published in Life sciences (1973) (01-02-2024)“…Anabolic-androgenic steroids (AAS) abuse is often associated with metabolic disorders and infertility. However, the current evidence on AAS-induced…”
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4
Aluminum: A potentially toxic metal with dose-dependent effects on cardiac bioaccumulation, mineral distribution, DNA oxidation and microstructural remodeling
Published in Environmental pollution (1987) (01-11-2018)“…Large amounts of aluminum (Al) are found in wastewater from industrial bauxite mining, which is often responsible for the contamination of drinking water…”
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5
Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids
Published in Food and chemical toxicology (01-06-2018)“…Remains unknown if dietary lipids and anabolic steroids (AS) can interact to modify energy metabolism, hepatic structure and function. We investigated the…”
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6
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice
Published in Free radical biology & medicine (01-12-2018)“…Elderly organisms are more susceptible to infectious diseases. However, the impact of aging on antiparasitic mechanisms, especially the nitric oxide pathway,…”
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Applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections: a systematic review of preclinical in vivo evidence
Published in Parasitology (01-09-2017)“…Chagas disease and sleeping sickness are neglected tropical diseases closely related to poverty, for which the development of plant-derived treatments has not…”
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Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study
Published in Life sciences (1973) (15-09-2020)“…Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas…”
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Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy
Published in International immunopharmacology (15-02-2024)“…•BZN mitigated T. cruzi-induced weight loss and death in S. mansoni co-infected mice.•Co-infection attenuated the levels of cytokines induced by T. cruzi and…”
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10
The mitochondrial uncoupler 2,4-dinitrophenol modulates inflammatory and oxidative responses in Trypanosoma cruzi-induced acute myocarditis in mice
Published in Cardiovascular pathology (01-09-2024)“…•A 2,4-Dinitrophenol (DNP) effect was investigated in T. cruzi-induced myocarditis.•DNP was compared to Benznidazole (Bz) effect in T. cruzi-induced…”
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11
Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?
Published in Pharmacological research (01-08-2020)“…[Display omitted] Phenothiazines inhibit major antioxidant defense mechanisms in trypanosomatids and exhibit potent cytotoxic effects in vitro. However, the…”
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Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats
Published in Oxidative medicine and cellular longevity (2021)“…The main objective of this study was to investigate the action of doxycycline hyclate (Dx) in the skin wound healing process in Wistar rats. We investigated…”
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13
Predictive metabolomic signatures of end-stage renal disease: A multivariate analysis of population-based data
Published in Biochimie (01-09-2018)“…The variability of molecular signatures and predictive low molecular weight markers of chronic kidney disease (CKD) in different populations are poorly…”
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Doxycycline aggravates granulomatous inflammation and lung microstructural remodeling induced by Schistosoma mansoni infection
Published in International immunopharmacology (01-05-2021)“…•Doxycycline (Dox) was tested on S. mansoni-induced granulomatous inflammation.•Dox increased cytokines production, macrophages and neutrophils…”
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Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative/nitrosative stress and heart disease in T. cruzi-infected mice
Published in Parasitology (01-06-2017)“…We compared the relevance of ibuprofen, vitamins C and E to control oxidative/nitrosative stress and heart disease in mice infected by Trypanosoma cruzi. Swiss…”
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Trans-fatty acids aggravate anabolic steroid-induced metabolic disturbances and differential gene expression in muscle, pancreas and adipose tissue
Published in Life sciences (1973) (01-09-2019)“…Although anabolic steroids (AS) and trans-fatty acids overload exerts systemic toxicity and are independent risk factors for metabolic and cardiovascular…”
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Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes
Published in BioMed research international (01-01-2017)“…The effect of topical application of ointment based on Strychnos pseudoquina hydroethanolic extract in the cutaneous wounds healing in diabetic rats was…”
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18
Parasite control and skeletal myositis in Trypanosoma cruzi-infected and exercised rats
Published in Acta tropica (01-06-2017)“…Non-pharmacological strategies have been rarely described in the treatment of infectious diseases. Although exercise training has been recently incorporated in…”
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Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy
Published in Life sciences (1973) (01-05-2016)“…The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an…”
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Haematological alterations in non-human hosts infected with Trypanosoma cruzi: a systematic review
Published in Parasitology (01-02-2019)“…American trypanosomiasis is a neglected tropical disease whose spectrum has not been quite understood, including the impact of Trypanosoma cruzi infection on…”
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