Acetylcholinesterase inhibition starting from extracts of Bauhinia variegata L., Bauhinia var. candida (Aiton) Buch.-Ham., and Bauhinia ungulata L

A treatment to the Alzheimer's disease consists inhibition of the acetylcholinesterase, which is responsible for the acetylcholine control in the synapses. We have investigated the potential of inhibition of the acetylcholinesterase produced by hexane extracts of leaves, branches, and flowers f...

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Published in:	Revista da Sociedade Brasileira de Medicina Tropical Vol. 44; no. 6; pp. 781 - 783
Main Authors:	Santos, Kamilla Monteiro dos, Gonçalves, Priscila Sant'Ana, Paiva, Maria José Nunes de, Lacerda, Guilherme Araújo
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Medicina Tropical 01-12-2011 Sociedade Brasileira de Medicina Tropical - SBMT Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:	Acetilcolinesterase Alzheimer's disease Bauhinia Bauhinia - chemistry Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Chromatography, Thin Layer Cromatografia Factor analysis Flowers Flowers - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Thin layer chromatography TROPICAL MEDICINE Cromatografia Acetilcolinesterase Bauhinia Acetylcholinesterase Chromatography
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Summary:	A treatment to the Alzheimer's disease consists inhibition of the acetylcholinesterase, which is responsible for the acetylcholine control in the synapses. We have investigated the potential of inhibition of the acetylcholinesterase produced by hexane extracts of leaves, branches, and flowers from three Bauhinia specimens, which is based on the technique of thin layer chromatography and on identifying the organ of the plant that possesses larger concentration of inhibitors. Retention factor analysis shows values of 0.31aA, 0.31aA, and 0.46aB for flowers B. variegata, B. var. candida, and B. ungulata, respectively. The flower extract of B. ungulata is the most suitable for further studies on this inhibition.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0037-8682 1678-9849 1678-9849 0037-8682
DOI:	10.1590/s0037-86822011000600025