Search Results - "Gonçalves, Pedro"
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Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease
Published in Pharmacological research (01-09-2020)“…[Display omitted] Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated with chronic inflammation of the gut, having a high…”
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A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease
Published in Inflammatory bowel diseases (16-02-2018)“…Abstract Gut microbiota has a fundamental role in the energy homeostasis of the host and is essential for proper "education" of the immune system. Intestinal…”
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Energy-efficient network activity from disparate circuit parameters
Published in Proceedings of the National Academy of Sciences - PNAS (01-11-2022)“…Neural circuits can produce similar activity patterns from vastly different combinations of channel and synaptic conductances. These conductances are tuned for…”
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Butyrate and colorectal cancer: the role of butyrate transport
Published in Current drug metabolism (01-11-2013)“…Colorectal cancer (CRC) is one of the most common solid tumors worldwide. A diet rich in dietary fiber is associated with a reduction in its risk. Butyrate…”
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Training deep neural density estimators to identify mechanistic models of neural dynamics
Published in eLife (17-09-2020)“…Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of underlying causes. However, determining which model parameters agree with…”
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Benchmarking microbiome transformations favors experimental quantitative approaches to address compositionality and sampling depth biases
Published in Nature communications (11-06-2021)“…While metagenomic sequencing has become the tool of preference to study host-associated microbial communities, downstream analyses and clinical interpretation…”
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Integration of sleep homeostasis and navigation in Drosophila
Published in PLoS computational biology (01-07-2021)“…During sleep, the brain undergoes dynamic and structural changes. In Drosophila, such changes have been observed in the central complex, a brain area important…”
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Designing a youth‐led Dialogue Forum tool: The CO‐CREATE experience
Published in Obesity reviews (01-09-2023)“…Summary While obesity prevention represents an established field of research, the inclusion of young people, who are regularly cited as an important priority…”
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Meta-analysis of livestock effects on tree regeneration in oak agroforestry systems
Published in Journal of environmental management (01-07-2024)“…Livestock grazing occupies over a quarter of terrestrial land and is prevalent to agroforestry ecosystems, potentially affecting the survival, growth, and…”
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Conflict, Competition, and Cooperation Regulate Social Interactions in Filamentous Fungi
Published in Annual review of microbiology (08-09-2020)“…Social cooperation impacts the development and survival of species. In higher taxa, kin recognition occurs via visual, chemical, or tactile cues that dictate…”
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Severely burned wood from wildfires has low functional potential in streams
Published in The Journal of applied ecology (01-06-2021)“…More frequent and more severe forest fires mean more severely burned wood in streams. Instream wood provides habitat complexity, alters geomorphology, retains…”
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Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2020)“…Nematode-trapping fungi (NTF) are a group of specialized microbial predators that consume nematodes when food sources are limited. Predation is initiated when…”
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Regulated Forms of Cell Death in Fungi
Published in Frontiers in microbiology (21-09-2017)“…Cell death occurs in all domains of life. While some cells die in an uncontrolled way due to exposure to external cues, other cells die in a regulated manner…”
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The geometry of robustness in spiking neural networks
Published in eLife (30-05-2022)“…Neural systems are remarkably robust against various perturbations, a phenomenon that still requires a clear explanation. Here, we graphically illustrate…”
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Key processes required for the different stages of fungal carnivory by a nematode-trapping fungus
Published in PLoS biology (21-11-2023)“…Nutritional deprivation triggers a switch from a saprotrophic to predatory lifestyle in soil-dwelling nematode-trapping fungi (NTF). In particular, the NTF…”
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Antipsychotics-induced metabolic alterations: Focus on adipose tissue and molecular mechanisms
Published in European neuropsychopharmacology (01-01-2015)“…Abstract The use of antipsychotic drugs for the treatment of mood disorders and psychosis has increased dramatically over the last decade. Despite its…”
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Cardiovascular Risk Reduction After Renal Denervation According to Time in Therapeutic Systolic Blood Pressure Range
Published in Journal of the American College of Cardiology (15-11-2022)“…Renal denervation (RDN) has been shown to lower blood pressure (BP), but its effects on cardiovascular events have only been preliminarily evaluated. Time in…”
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The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review
Published in Frontiers in pharmacology (13-01-2021)“…Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary KPF in reducing the…”
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A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition
Published in eLife (30-08-2022)“…Organisms require the ability to differentiate themselves from organisms of different or even the same species. Allorecognition processes in filamentous fungi…”
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Anomalous origin of the right coronary artery with interarterial course: a mid-term follow-up of 28 cases
Published in Scientific reports (21-09-2021)“…Anomalous origin of the right coronary artery from the opposite sinus (right-ACAOS) with interarterial course (IAC) has been associated with increased risk of…”
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