Search Results - "Gonçalves, Giselle Martins"
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TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis
Published in PloS one (24-05-2012)“…The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-induced AKI. C57BL/6 TLR2(-/-), TLR4(-/-) and MyD88(-/-) male mice were…”
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MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages
Published in Molecular medicine (Cambridge, Mass.) (24-10-2012)“…Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like…”
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Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis
Published in PloS one (14-12-2011)“…Tubule-interstitial nephritis (TIN) results in decreased renal function and interstitial inflammation, which ultimately leads to fibrosis. Excessive adenine…”
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Transcriptome analysis of renal ischemia/reperfusion injury and its modulation by ischemic pre-conditioning or hemin treatment
Published in PloS one (14-11-2012)“…Ischemia/reperfusion injury (IRI) is a leading cause of acute renal failure. The definition of the molecular mechanisms involved in renal IRI and counter…”
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5
A Role for galectin-3 in renal tissue damage triggered by ischemia and reperfusion injury
Published in Transplant international (01-10-2008)“…Ischemic-reperfusion injury (IRI) triggers an inflammatory response involving neutrophils/macrophages, lymphocytes and endothelial cells. Galectin-3 is a…”
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Quinine and chloroquine: Potential preclinical candidates for the treatment of tegumentary Leishmaniasis
Published in Acta tropica (01-04-2024)“…•Inhibition of Leishmania growth was observed in vitro and in vivo after treatment with chloroquine.•Antimalarials demonstrated lower cytotoxicity than…”
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TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury
Published in Clinical science (1979) (31-08-2018)“…Acute kidney injury (AKI) is considered an inflammatory disease in which toll-like receptors (TLRs) signaling pathways play an important role. The activation…”
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The role of innate immunity in septic acute kidney injuries
Published in Shock (Augusta, Ga.) (01-09-2010)“…Acute kidney injury (AKI) is an important clinical syndrome characterized by abnormalities in the hydroelectrolytic balance. Because of high rates of morbidity…”
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Role of Toll-like receptors in local effects in a model of experimental envenoming induced by Bothrops jararacussu snake venom and by two phospholipases A2
Published in Toxicon (Oxford) (30-07-2022)“…Literature shows that phospholipases A2 isolated from snake venoms of the genus Bothrops are involved in the local inflammatory response. However, the…”
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Influence of TH1/TH2 switched immune response on renal ischemia-reperfusion injury
Published in Nephron. Experimental nephrology (01-01-2006)“…Recent evidence shows a critical role of the CD4+ T cell with the Th1/Th2 paradigm as a possible effector mechanism in ischemia and reperfusion injury. We…”
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Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease
Published in Einstein (São Paulo, Brazil) (01-12-2009)“…Objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to…”
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Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection
Published in PloS one (31-08-2012)“…Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the…”
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13
Role of Toll-like receptors in local effects in a model of experimental envenoming induced by Bothrops jararacussu snake venom and by two phospholipases A 2
Published in Toxicon (Oxford) (30-07-2022)“…Literature shows that phospholipases A isolated from snake venoms of the genus Bothrops are involved in the local inflammatory response. However, the…”
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14
TH1/TH2 pattern of renal tissues in acute and chronic animal models treated with mesenchymal stem cells
Published in Brazilian Journal of Transplantation (01-06-2007)“…Mesenchymal stem cell (MSC) therapy is a promising new therapy for kidney diseases. Many authors have been demonstrated that the MSC treatment leads to N…”
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Heme oxygenase 1 and renal ischemia and reperfusion injury: The impact of immunosuppressive drug
Published in International immunopharmacology (20-12-2006)“…Ischemia and reperfusion injury (IRI) is the main etiology of acute renal failure in native and transplanted kidneys. In the transplantation field,…”
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