Search Results - "Gomperts, Stephen N."

Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases by Gomperts, Stephen N, Locascio, Joseph J, Makaretz, Sara J, Schultz, Aaron, Caso, Christina, Vasdev, Neil, Sperling, Reisa, Growdon, John H, Dickerson, Bradford C, Johnson, Keith

“…The causes of cognitive impairment in dementia with Lewy bodies (DLB) and Parkinson disease (PD) are multifactorial. Tau pathologic changes are commonly…”
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VTA neurons coordinate with the hippocampal reactivation of spatial experience by Gomperts, Stephen N, Kloosterman, Fabian, Wilson, Matthew A

“…Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and…”
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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue by Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa

“…Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451…”
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Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease by Zhou, Heng, Li, Hanyan, Gowravaram, Niket, Quan, Moqin, Kausar, Naila, Gomperts, Stephen N.

“…The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of…”
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Neural representation of spatial topology in the rodent hippocampus by Chen, Zhe, Gomperts, Stephen N, Yamamoto, Jun, Wilson, Matthew A

“…Pyramidal cells in the rodent hippocampus often exhibit clear spatial tuning in navigation. Although it has been long suggested that pyramidal cell activity…”
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Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease by Shirvan, Julia, Clement, Nathan, Ye, Rong, Katz, Samantha, Schultz, Aaron, Johnson, Keith A, Gomez-Isla, Teresa, Frosch, Matthew, Growdon, John H, Gomperts, Stephen N

“…OBJECTIVETo develop imaging biomarkers of diseases in the Lewy body spectrum and to validate these markers against postmortem neuropathologic findings…”
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Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model by Zhao, Qiuchen, Yokomizo, Shinya, Perle, Stephen J., Lee, Yee Fun, Zhou, Heng, Miller, Morgan R., Li, Hanyan, Gerashchenko, Dmitry, Gomperts, Stephen N., Bacskai, Brian J., Kastanenka, Ksenia V.

“…Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta…”
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Brain amyloid and cognition in Lewy body diseases by Gomperts, Stephen N., Locascio, Joseph J., Marquie, Marta, Santarlasci, Andrea L., Rentz, Dorene M., Maye, Jacqueline, Johnson, Keith A., Growdon, John H.

“…Many patients with PD develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies (DLB); PDD and DLB…”
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Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology by Lee, Yee Fun, Russ, Alyssa N., Zhao, Qiuchen, Perle, Stephen J., Maci, Megi, Miller, Morgan R., Hou, Steven S., Algamal, Moustafa, Zhao, Zhuoyang, Li, Hanyan, Gelwan, Noah, Liu, Zhe, Gomperts, Stephen N., Araque, Alfonso, Galea, Elena, Bacskai, Brian J., Kastanenka, Ksenia V.

“…Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves…”
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Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology by Kastanenka, Ksenia V., Calvo-Rodriguez, Maria, Hou, Steven S., Zhou, Heng, Takeda, Shuko, Arbel-Ornath, Michal, Lariviere, Amanda, Lee, Yee Fun, Kim, Alex, Hawkes, Jonathan M., Logan, Robert, Feng, Danielle, Chen, Xiqun, Gomperts, Stephen N., Bacskai, Brian J.

“…Neuronal activity patterns are disrupted in neurodegenerative disorders, including Alzheimer’s disease (AD). One example is disruption of corticothalamic slow…”
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Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model by Zhao, Qiuchen, Maci, Megi, Miller, Morgan R, Zhou, Heng, Zhang, Fang, Algamal, Moustafa, Lee, Yee Fun, Hou, Steven S, Perle, Stephen J, Le, Hoang, Russ, Alyssa N, Lo, Eng H, Gerashchenko, Dmitry, Gomperts, Stephen N, Bacskai, Brian J, Kastanenka, Ksenia V

“…Alzheimer's disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep…”
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Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case by Marquié, Marta, Verwer, Eline E, Meltzer, Avery C, Kim, Sally Ji Who, Agüero, Cinthya, Gonzalez, Jose, Makaretz, Sara J, Siao Tick Chong, Michael, Ramanan, Prianca, Amaral, Ana C, Normandin, Marc D, Vanderburg, Charles R, Gomperts, Stephen N, Johnson, Keith A, Frosch, Matthew P, Gómez-Isla, Teresa

“…[F-18]-AV-1451 is a novel positron emission tomography (PET) tracer with high affinity to neurofibrillary tau pathology in Alzheimer's disease (AD). PET…”
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Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle by Zhou, Heng, Neville, Kevin R, Goldstein, Nitsan, Kabu, Shushi, Kausar, Naila, Ye, Rong, Nguyen, Thuan Tinh, Gelwan, Noah, Hyman, Bradley T, Gomperts, Stephen N

“…Calcium is a critical second messenger in neurons that contributes to learning and memory, but how the coordination of action potentials of neuronal ensembles…”
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Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia by Gomperts, Stephen N

“…ABSTRACTPurpose of ReviewThis article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia…”
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Topography of cortical thinning in the Lewy body diseases by Ye, Rong, Touroutoglou, Alexandra, Brickhouse, Michael, Katz, Samantha, Growdon, John H., Johnson, Keith A., Dickerson, Bradford C., Gomperts, Stephen N.

“…Regional cortical thinning in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) may underlie some aspect of their clinical impairments;…”
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Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease by Bai, Ping, Lan, Yu, Liu, Yan, Mondal, Prasenjit, Gomm, Ashley, Xu, Yulong, Wang, Yanli, Wang, Yongle, Kang, Leyi, Pan, Lili, Bagdasarian, Frederick A., Hallisey, Madelyn, Lobo, Fleur, Varela, Breanna, Choi, Se Hoon, Gomperts, Stephen N., Wey, Hsiao‐Ying, Shen, Shiqian, Tanzi, Rudolph E., Wang, Changning, Zhang, Can

“…Targeting receptor‐interacting protein kinase 1 (RIPK1) has emerged as a promising therapeutic stratagem for neurodegenerative disorders, particularly…”
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Micro-drive array for chronic in vivo recording: drive fabrication by Kloosterman, Fabian, Davidson, Thomas J, Gomperts, Stephen N, Layton, Stuart P, Hale, Gregory, Nguyen, David P, Wilson, Matthew A

“…Chronic recording of large populations of neurons is a valuable technique for studying the function of neuronal circuits in awake behaving rats. Lightweight…”
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Micro-drive array for chronic in vivo recording: tetrode assembly by Nguyen, David P, Layton, Stuart P, Hale, Gregory, Gomperts, Stephen N, Davidson, Thomas J, Kloosterman, Fabian, Wilson, Matthew A

“…The tetrode, a bundle of four electrodes, has proven to be a valuable tool for the simultaneous recording of multiple neurons in-vivo. The differential…”
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The association between cigarette smoking and dementia with Lewy bodies by Goodheart, Anna E., Gomperts, Stephen N.

“…Cigarette smoking is associated with a reduced risk of Parkinson's disease (PD). As dementia with Lewy bodies (DLB) and PD share core neuropathologic features,…”
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Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease by Xia, Chenjie, Makaretz, Sara J, Caso, Christina, McGinnis, Scott, Gomperts, Stephen N, Sepulcre, Jorge, Gomez-Isla, Teresa, Hyman, Bradley T, Schultz, Aaron, Vasdev, Neil, Johnson, Keith A, Dickerson, Bradford C

“…Previous postmortem studies have long demonstrated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated with Alzheimer…”
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