Search Results - "Gompels, Luke"

Artificial intelligence, bias and clinical safety by Challen, Robert, Denny, Joshua, Pitt, Martin, Gompels, Luke, Edwards, Tom, Tsaneva-Atanasova, Krasimira

Get more information

BSR and BHPR guideline for the treatment of systemic sclerosis by Denton, Christopher P, Hughes, Michael, Gak, Nataliya, Vila, Josephine, Buch, Maya H, Chakravarty, Kuntal, Fligelstone, Kim, Gompels, Luke L, Griffiths, Bridget, Herrick, Ariane L, Pang, Jay, Parker, Louise, Redmond, Anthony, van Laar, Jacob, Warburton, Louise, Ong, Voon H

Get full text

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
Get full text

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis by Lim, Ngee Han, Meinjohanns, Ernst, Bou‐Gharios, George, Gompels, Luke L., Nuti, Elisa, Rossello, Armando, Devel, Laurent, Dive, Vincent, Meldal, Morten, Nagase, Hideaki

“…Objective To develop enzyme‐activatable Förster resonance energy transfer (FRET) substrate probes to detect matrix metalloproteinase 12 (MMP‐12) and MMP‐13…”
Get full text

In vivo fluorescence imaging of E‐selectin: Quantitative detection of endothelial activation in a mouse model of arthritis by Gompels, Luke L., Madden, Leigh, Lim, Ngee Han, Inglis, Julia J., McConnell, Ellen, Vincent, Tonia L., Haskard, Dorian O., Paleolog, Ewa M.

“…Objective In vivo optical imaging can delineate at the macroscopic level processes that are occurring at the cellular and molecular levels. E‐selectin, a…”
Get full text

Imaging technologies for preclinical models of bone and joint disorders by Tremoleda, Jordi L, Khalil, Magdy, Gompels, Luke L, Wylezinska-Arridge, Marzena, Vincent, Tonia, Gsell, Willy

“…Preclinical models for musculoskeletal disorders are critical for understanding the pathogenesis of bone and joint disorders in humans and the development of…”
Get full text

A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis by Gompels, Luke L, Paleolog, Ewa M

“…Novel molecular imaging techniques are at the forefront of both preclinical and clinical imaging strategies. They have significant potential to offer…”
Get full text

In vivo optical imaging in arthritis—an enlightening future? by Gompels, Luke L., Lim, Ngee Han, Vincent, Tonia, Paleolog, Ewa M.

“…In vivo molecular optical imaging has significant potential to delineate and measure, at the macroscopic level, in vivo biological processes that are occurring…”
Get full text

Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade by Gompels, Luke L, Malik, Nasser M, Madden, Leigh, Jin, Pei, Feldmann, Marc, Shepard, H Michael, Paleolog, Ewa M

“…Rheumatoid arthritis (RA) is a chronic disease associated with inflammation and destruction of bone and cartilage. Although inhibition of TNFα is widely used…”
Get full text

Single-blind randomized trial of combination antibiotic therapy in rheumatoid arthritis by Gompels, Luke L, Smith, Angela, Charles, Peter J, Rogers, Wendy, Soon-Shiong, Joanne, Mitchell, Adam, Doré, Caroline, Taylor, Peter W, Mackworth-Young, Charles G

“…OBJECTIVE: To determine the potential clinical efficacy of combination antibiotic therapy in treating rheumatoid arthritis (RA). METHODS: Twenty-one patients…”
Get full text

Estimates of regional infectivity of COVID-19 in the United Kingdom following imposition of social distancing measures by Challen, Robert, Tsaneva-Atanasova, Krasimira, Pitt, Martin, Edwards, Tom, Gompels, Luke, Lacasa, Lucas, Brooks-Pollock, Ellen, Danon, Leon

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduction number has become an essential parameter for monitoring disease transmission…”
Get full text

The 2024 British Society for Rheumatology guideline for management of systemic sclerosis by Denton, Christopher P, De Lorenzis, Enrico, Roblin, Elen, Goldman, Nina, Alcacer-Pitarch, Begonya, Blamont, Emma, Buch, Maya H, Carulli, Maresa, Cotton, Caroline, Del Galdo, Francesco, Derrett-Smith, Emma, Douglas, Karen, Farrington, Sue, Fligelstone, Kim, Gompels, Luke, Griffiths, Bridget, Herrick, Ariane, Hughes, Michael, Pain, Clare, Pantano, Georgina, Pauling, John D, Prabu, Athiveeraramapandian, O'Donoghue, Nuala, Renzoni, Elisabetta A, Royle, Jeremy, Samaranayaka, Muditha, Spierings, Julia, Tynan, Aoife, Warburton, Louise, Ong, Voon H

“…This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare…”
Get full text

The 2024 British Society for Rheumatology guideline for management of systemic sclerosis-executive summary by Denton, Christopher P, De Lorenzis, Enrico, Roblin, Elen, Goldman, Nina, Alcacer-Pitarch, Begonya, Blamont, Emma, Buch, Maya H, Carulli, Maresa, Cotton, Caroline, Del Galdo, Francesco, Derrett-Smith, Emma, Douglas, Karen, Farrington, Sue, Fligelstone, Kim, Gompels, Luke, Griffiths, Bridget, Herrick, Ariane, Hughes, Michael, Pain, Clare, Pantano, Georgina, Pauling, John D, Prabu, Athiveeraramapandian, O'Donoghue, Nuala, Renzoni, Elisabetta A, Royle, Jeremy, Samaranayaka, Muditha, Spierings, Julia, Tynan, Aoife, Warburton, Louise, Ong, Voon H

“…This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare…”
Get full text

Factors influencing digital review of pathology test results in an inpatient setting: a cross-sectional study by Challen, Robert, Tsaneva-Atanasova, Krasimira, Edwards, Tom, Gompels, Luke, Dayer, Mark, Pitt, Martin, Danon, Leon

“…Delay or failure to view test results in a hospital setting can lead to delayed diagnosis, risk of patient harm, and represents inefficiency. Factors…”
Get full text

Management of systemic sclerosis: British Society for Rheumatology guideline scope by Denton, Christopher P, De Lorenzis, Enrico, Roblin, Elen, Goldman, Nina, Alcacer-Pitarch, Begonya, Blamont, Emma, Buch, Maya, Carulli, Maresa, Cotton, Caroline, del Galdo, Francesco, Derrett-Smith, Emma, Douglas, Karen, Farrington, Sue, Fligelstone, Kim, Gompels, Luke, Griffiths, Bridget, Herrick, Ariane, Hughes, Michael, Pain, Clare, Pantano, Georgina, Pauling, John, Prabu, Athiveeraramapandian, O’Donoghue, Nuala, Renzoni, Elisabetta, Royle, Jeremy, Samaranayaka, Muditha, Spierings, Julia, Tynan, Aoife, Warburton, Louise, Ong, Voon

“…Abstract This guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in…”
Get full text

Advances in the imaging of rheumatic diseases. A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis by Gompels, Luke L, Paleolog, Ewa M

Get full text

Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome? by Lendrem, Dennis, Mitchell, Sheryl, McMeekin, Peter, Gompels, Luke, Hackett, Katie, Bowman, Simon, Price, Elizabeth, Pease, Colin T, Emery, Paul, Andrews, Jacqueline, Lanyon, Peter, Hunter, John, Gupta, Monica, Bombardieri, Michele, Sutcliffe, Nurhan, Pitzalis, Costantino, McLaren, John, Cooper, Annie, Regan, Marian, Giles, Ian, Isenberg, David, Saravanan, Vadivelu, Coady, David, Dasgupta, Bhaskar, McHugh, Neil, Young-Min, Steven, Moots, Robert, Gendi, Nagui, Akil, Mohammed, Griffiths, Bridget, Ng, Wan-Fai

“…This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the…”
Get full text

In vivo fluorescence imaging of e-selectin: quantitative detection of endothelial activation in arthritis by Gompels, Luke

“…Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage…”
Get full text

Treatmentof murine osteoarthritis withTrkAd5 reveals a pivotal rolefor nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
Get full text

Concurrent Oral 9 – Rheumatoid Arthritis: Aetiopathogenesis [OP59–OP64] by Biliavska, Iuliia V., Bortkevych, Oleg P., Ceeraz, Sabrina, Spencer, Jo, Choy, Ernest H., Corrigall, Valerie, Bombardieri, Michele, Ngar Woon Kam, Yvonne, Brentano, Fabia, Choi, Ken, Kyburz, Diego, Gay, Steffen, McInnes, Iain B., Pitzalis, Costantino, Gompels, Luke L., Vincent, Tonia, Madden, Leigh, Lim, Ngee H., McConnell, Ellen, Mcnamee, Kay, Haskard, Dorian O., Paleolog, Ewa M., Swales, Catherine, Mahoney, David J., Athanasou, Nicholas A., Bombardieri, Michele, Pitzalis, Costantino, Sharif, Omar, Day, Anthony J., Milner, Caroline M., Sabokbar, Afsie, Knowles, Helen, Cleton-Jansen, Anne-Marie, Korsching, Eberhard, Athanasou, Nick

“…Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA)…”
Get full text