Search Results - "Gomis, R."

From latency to overt bone metastasis in breast cancer: potential for treatment and prevention by Salvador, Fernando, Llorente, Alicia, Gomis, Roger R

“…Bone metastasis is present in a high percentage of breast cancer (BCa) patients with distant disease, especially in those with the estrogen receptor‐positive…”
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Tumor cell dormancy by Gomis, Roger R., Gawrzak, Sylwia

“…Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are…”
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The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21 by Soria-Valles, C, Gutiérrez-Fernández, A, Guiu, M, Mari, B, Fueyo, A, Gomis, R R, López-Otín, C

“…Matrix metalloproteinases (MMPs) have been traditionally implicated in cancer progression because of their ability to degrade the extracellular matrix…”
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CLK2 blockade modulates alternative splicing compromising MYC‐driven breast tumors by Salvador, Fernando, Gomis, Roger R

“…MYC oncogene overexpression/amplification is common in multiple human cancers, in which it regulates proliferation, apoptosis and cell metabolism, among other…”
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Paradoxical suboptimal vitamin D levels in a Mediterranean area: a population-based study by Díaz-Rizzolo, D. A., Kostov, B., Gomis, R., Sisó-Almirall, A.

“…Policies in sunny countries, such as those in the Mediterranean area, do not promote vitamin D supplementation despite some studies might suggest the high…”
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Benefits and risks of adjuvant treatment with zoledronic acid in stage II/III breast cancer. 10 years follow-up of the AZURE randomized clinical trial (BIG 01/04) by Coleman, R.E., Collinson, M., Gregory, W., Marshall, H., Bell, R., Dodwell, D., Keane, M., Gil, M., Barrett-Lee, P., Ritchie, D., Bowman, A., Liversedge, V., De Boer, R.H., Passos-Coelho, J.L., O'Reilly, S., Bertelli, G., Joffe, J., Brown, J.E., Wilson, C., Tercero, J.C., Jean-Mairet, J., Gomis, R., Cameron, D.

“…Adjuvant bisphosphonates improve disease outcomes in postmenopausal early breast cancer (EBC) but the long-term effects are poorly described. The AZURE trial…”
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Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy by Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orrillo, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andres, Montagut, Clara, Calon, Alexandre

“…A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply…”
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Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors by Rivas, Elisa I., Linares, Jenniffer, Zwick, Melissa, Gómez-Llonin, Andrea, Guiu, Marc, Labernadie, Anna, Badia-Ramentol, Jordi, Lladó, Anna, Bardia, Lídia, Pérez-Núñez, Iván, Martínez-Ciarpaglini, Carolina, Tarazona, Noelia, Sallent-Aragay, Anna, Garrido, Marta, Celià-Terrassa, Toni, Burgués, Octavio, Gomis, Roger R., Albanell, Joan, Calon, Alexandre

“…About 50% of human epidermal growth factor receptor 2 (HER2)+ breast cancer patients do not benefit from HER2-targeted therapy and almost 20% of them relapse…”
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MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery by Oller-Salvia, Benjamí, Sánchez-Navarro, Macarena, Ciudad, Sonia, Guiu, Marc, Arranz-Gibert, Pol, Garcia, Cristina, Gomis, Roger R., Cecchelli, Roméo, García, Jesús, Giralt, Ernest, Teixidó, Meritxell

“…Drug delivery across the blood–brain barrier (BBB) is a formidable challenge for therapies targeting the central nervous system. Although BBB shuttle peptides…”
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Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study by Soriguer, F., Goday, A., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M. T., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Rojo-Martínez, G., Serrano-Rios, M., Valdés, S., Vázquez, J. A., Vendrell, J.

“…Aims/hypothesis The Di@bet.es Study is the first national study in Spain to examine the prevalence of diabetes and impaired glucose regulation. Methods A…”
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Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study by Gomis, R., Espadero, R.-M., Jones, R., Woerle, H. J., Dugi, K. A.

“…Aims: To compare the efficacy, safety and tolerability of linagliptin or placebo administered for 24 weeks in combination with pioglitazone in patients with…”
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Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study by Rojo-Martínez, G., Valdés, S., Soriguer, F., Vendrell, J., Urrutia, I., Pérez, V., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González- Frutos, T., Gomis, R., Goday, A., García-Serrano, S., García-Escobar, E., Galán-García, J. L., Castell, C., Badía-Guillén, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Franch-Nadal, J., Delgado, E., Chaves, F. J., Castaño, L., Calle-Pascual, A.

“…Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the…”
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Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4 by Casas, S, Novials, A, Reimann, F, Gomis, R, Gribble, F. M

“…Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide (hIAPP) fibril formation results in calcium influx across the plasma…”
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Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial by Coleman, Robert, Hall, Andrew, Albanell, Joan, Hanby, Andrew, Bell, Richard, Cameron, David, Dodwell, David, Marshall, Helen, Jean-Mairet, Joël, Tercero, Juan-Carlos, Rojo, Federico, Gregory, Walter, Gomis, Roger R

“…Adjuvant use of bisphosphonates can reduce the incidence of bone metastases in early breast cancer. Recurrence and survival seem to be improved only in…”
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A FoxO-Smad Synexpression Group in Human Keratinocytes by Gomis, Roger R., Alarcón, Claudio, He, Wei, Wang, Qiongqing, Seoane, Joan, Lash, Alex, Massagué, Joan

“…Transforming growth factor β (TGF-β) signals through activation of Smad transcription factors. Activated Smad proteins associate with different DNA-binding…”
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Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity by Díaz-Rizzolo, D.A., Kostov, B., López-Siles, M., Serra, A., Colungo, C., González-de-Paz, L., Martinez-Medina, M., Sisó-Almirall, A., Gomis, R.

“…Prediabetes and old age are both high risk factors for developing Type 2 Diabetes (T2D), while obesity is one of the most important factors triggering the…”
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Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial by Díaz-Rizzolo, D.A., Serra, A., Colungo, C., Sala-Vila, A., Sisó-Almirall, A., Gomis, R.

“…Fish could play a role in preventing type 2 diabetes (T2D) but there has been little specification about the type of fish and the preventive mechanism involved…”
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FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth by Slebe, Felipe, Rojo, Federico, Vinaixa, Maria, García-Rocha, Mar, Testoni, Giorgia, Guiu, Marc, Planet, Evarist, Samino, Sara, Arenas, Enrique J., Beltran, Antoni, Rovira, Ana, Lluch, Ana, Salvatella, Xavier, Yanes, Oscar, Albanell, Joan, Guinovart, Joan J., Gomis, Roger R.

“…The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on…”
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TGF-β Family Signaling in Tumor Suppression and Cancer Progression by Seoane, Joan, Gomis, Roger R

“…Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways…”
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The PP2A regulator IER5L supports prostate cancer progression by Crespo, Jana R., Martín-Martín, Natalia, Garcia-Longarte, Saioa, Corres-Mendizabal, Jon, Carlevaris, Onintza, Astobiza, Ianire, Zabala-Letona, Amaia, Guiu, Marc, Azkargorta, Mikel, Gonzalez-Lopez, Monika, Macías-Cámara, Nuria, Doan, Phuong, Elortza, Félix, Mendizabal, Isabel, Westermack, Jukka, Gomis, Roger R., Ercilla, Amaia, Carracedo, Arkaitz

“…Prostate cancer exhibits high prevalence and accounts for a high number of cancer-related deaths. The discovery and characterization of molecular determinants…”
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