Search Results - "Gomeza, Jesus"

Lack of beta-arrestin signaling in the absence of active G proteins by Grundmann, Manuel, Merten, Nicole, Malfacini, Davide, Inoue, Asuka, Preis, Philip, Simon, Katharina, Rüttiger, Nelly, Ziegler, Nicole, Benkel, Tobias, Schmitt, Nina Katharina, Ishida, Satoru, Müller, Ines, Reher, Raphael, Kawakami, Kouki, Inoue, Ayumi, Rick, Ulrike, Kühl, Toni, Imhof, Diana, Aoki, Junken, König, Gabriele M., Hoffmann, Carsten, Gomeza, Jesus, Wess, Jürgen, Kostenis, Evi

“…G protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins…”
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Reply to: How carvedilol does not activate β2-adrenoceptors by Kostenis, Evi, Gomeza, Jesus, Miess-Tanneberg, Elke, Blum, Nina Kathleen, Benkel, Tobias, Chevigné, Andy, Hoffmann, Carsten, Kolb, Peter, Nikolaev, Viacheslav, Waldhoer, Maria, Szpakowska, Martyna, Inoue, Asuka, Schulz, Stefan

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Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells by Schröder, Ralf, Schmidt, Johannes, Blättermann, Stefanie, Peters, Lucas, Janssen, Nicole, Grundmann, Manuel, Seemann, Wiebke, Kaufel, Dorina, Merten, Nicole, Drewke, Christel, Gomeza, Jesus, Milligan, Graeme, Mohr, Klaus, Kostenis, Evi

“…Label-free dynamic mass redistribution (DMR) is a cutting-edge assay technology that enables real-time detection of integrated cellular responses in living…”
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How Carvedilol activates β2-adrenoceptors by Benkel, Tobias, Zimmermann, Mirjam, Zeiner, Julian, Bravo, Sergi, Merten, Nicole, Lim, Victor Jun Yu, Matthees, Edda Sofie Fabienne, Drube, Julia, Miess-Tanneberg, Elke, Malan, Daniela, Szpakowska, Martyna, Monteleone, Stefania, Grimes, Jak, Koszegi, Zsombor, Lanoiselée, Yann, O’Brien, Shannon, Pavlaki, Nikoleta, Dobberstein, Nadine, Inoue, Asuka, Nikolaev, Viacheslav, Calebiro, Davide, Chevigné, Andy, Sasse, Philipp, Schulz, Stefan, Hoffmann, Carsten, Kolb, Peter, Waldhoer, Maria, Simon, Katharina, Gomeza, Jesus, Kostenis, Evi

“…Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this…”
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Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation by Merten, Nicole, Fischer, Julia, Simon, Katharina, Zhang, Liguo, Schröder, Ralf, Peters, Lucas, Letombe, Anne-Gaelle, Hennen, Stephanie, Schrage, Ramona, Bödefeld, Theresa, Vermeiren, Celine, Gillard, Michel, Mohr, Klaus, Lu, Qing Richard, Brüstle, Oliver, Gomeza, Jesus, Kostenis, Evi

“…Identification of additional uses for existing drugs is a hot topic in drug discovery and a viable alternative to de novo drug development. HAMI3379 is known…”
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Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity by Malfacini, Davide, Patt, Julian, Annala, Suvi, Harpsøe, Kasper, Eryilmaz, Funda, Reher, Raphael, Crüsemann, Max, Hanke, Wiebke, Zhang, Hang, Tietze, Daniel, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, Gabriele M., Inoue, Asuka, Gomeza, Jesus, Kostenis, Evi

“…Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these…”
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Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice by Zhang, Weilie, Basile, Anthony S, Gomeza, Jesus, Volpicelli, Laura A, Levey, Allan I, Wess, Jurgen

“…Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play important roles in many fundamental central functions, including…”
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A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter by Rickhag, Mattias, Hansen, Freja Herborg, Sørensen, Gunnar, Strandfelt, Kristine Nørgaard, Andresen, Bjørn, Gotfryd, Kamil, Madsen, Kenneth L., Vestergaard Klewe, Ib, Ammendrup-Johnsen, Ina, Eriksen, Jacob, Newman, Amy H., Füchtbauer, Ernst-Martin, Gomeza, Jesus, Woldbye, David P.D., Wörtwein, Gitta, Gether, Ulrik

“…The dopamine transporter mediates reuptake of dopamine from the synaptic cleft. The cellular mechanisms controlling dopamine transporter levels in striatal…”
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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice by Gomeza, Jesus, Zhang, Lu, Kostenis, Evi, Felder, Christian

“…Muscarinic acetylcholine receptors (M 1 –M 5 ) regulate many key functions of the central and peripheral nervous system. Primarily because of the lack of…”
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Pronounced Pharmacologic Deficits in M2 Muscarinic Acetylcholine Receptor Knockout Mice by Gomeza, Jesus, Shannon, Harlan, Kostenis, Evi, Felder, Christian, Zhang, Lu, Brodkin, Jesse, Grinberg, Alexander, Sheng, Hui, Wess, Jurgen

“…Members of the muscarinic acetylcholine receptor family (M1-M5) are known to be involved in a great number of important central and peripheral physiological…”
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Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity by Bymaster, Frank P., Carter, Petra A., Yamada, Masahisa, Gomeza, Jesus, Wess, Jürgen, Hamilton, Susan E., Nathanson, Neil M., McKinzie, David L., Felder, Christian C.

“…Muscarinic agonist‐induced parasympathomimetic effects, in vivo phosphoinositide hydrolysis and seizures were evaluated in wild‐type and muscarinic M1–M5…”
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The experimental power of FR900359 to study Gq-regulated biological processes by Schrage, Ramona, Schmitz, Anna-Lena, Gaffal, Evelyn, Annala, Suvi, Kehraus, Stefan, Wenzel, Daniela, Büllesbach, Katrin M., Bald, Tobias, Inoue, Asuka, Shinjo, Yuji, Galandrin, Ségolène, Shridhar, Naveen, Hesse, Michael, Grundmann, Manuel, Merten, Nicole, Charpentier, Thomas H., Martz, Matthew, Butcher, Adrian J., Slodczyk, Tanja, Armando, Sylvain, Effern, Maike, Namkung, Yoon, Jenkins, Laura, Horn, Velten, Stößel, Anne, Dargatz, Harald, Tietze, Daniel, Imhof, Diana, Galés, Céline, Drewke, Christel, Müller, Christa E., Hölzel, Michael, Milligan, Graeme, Tobin, Andrew B., Gomeza, Jesús, Dohlman, Henrik G., Sondek, John, Harden, T. Kendall, Bouvier, Michel, Laporte, Stéphane A., Aoki, Junken, Fleischmann, Bernd K., Mohr, Klaus, König, Gabriele M., Tüting, Thomas, Kostenis, Evi

“…Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental…”
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Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice by Duttaroy, Alokesh, Gomeza, Jesus, Gan, Jai-Wei, Siddiqui, Nasir, Basile, Anthony S, Harman, W Dean, Smith, Philip L, Felder, Christian C, Levey, Allan I, Wess, Jürgen

“…Centrally active muscarinic agonists display pronounced analgesic effects. Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s)…”
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Neurotransmitter transporters expressed in glial cells as regulators of synapse function by Eulenburg, Volker, Gomeza, Jesús

“…Abstract Synaptic neurotransmission at high temporal and spatial resolutions requires efficient removal and/or inactivation of presynaptically released…”
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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements by Mohr, Klaus, Kostenis, Evi, Schröder, Ralf, Janssen, Nicole, Schmidt, Johannes, Kebig, Anna, Merten, Nicole, Hennen, Stephanie, Müller, Anke, Blättermann, Stefanie, Mohr-Andrä, Marion, Zahn, Sabine, Wenzel, Jörg, Smith, Nicola J, Gomeza, Jesús, Drewke, Christel, Milligan, Graeme

“…Label-free methods for assaying GPCR signaling promise to illuminate the effects of drugs in therapeutically relevant primary cells. Kostenis and colleagues…”
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Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes by Schulz, Daniel, Morschel, Julia, Schuster, Stefanie, Eulenburg, Volker, Gomeza, Jesús

“…The endogenous neutral amino acid L-proline exhibits a variety of physiological and behavioral actions in the nervous system, highlighting the importance of…”
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Giving ERK a jERK from the endosome by Kostenis, Evi, Bravo, Sergi, Gomeza, Jesus

“…Endosomes, long considered as sorting stations for downregulation and recycling of cell surface G protein-coupled receptors (GPCRs), are now well-established…”
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Elucidating the role of muscarinic receptors in psychosis by Felder, Christian C., Porter, Amy C., Skillman, Tiffanie L., Zhang, Lu, Bymaster, Frank P., Nathanson, Neil M., Hamilton, Susan E., Gomeza, Jesus, Wess, Jurgen, McKinzie, David L.

“…Muscarinic receptors have been implicated in the regulation of cognition and psychosis based on pharmacological evidence from pre-clinical and clinical…”
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Assignment of Muscarinic Receptor Subtypes Mediating G-Protein Modulation of Ca2+Channels by Using Knockout Mice by Shapiro, Mark S., Loose, Michael D., Hamilton, Susan E., Nathanson, Neil M., Gomeza, Jesus, Wess, Jurgen, Hille, Bertil

“…There are five known subtypes of muscarinic receptors (M1-M5). We have used knockout mice lacking the M1, M2, or M4receptors to determine which subtypes…”
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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors by Brands, Julian, Bravo, Sergi, Jürgenliemke, Lars, Grätz, Lukas, Schihada, Hannes, Frechen, Fabian, Alenfelder, Judith, Pfeil, Cy, Ohse, Paul Georg, Hiratsuka, Suzune, Kawakami, Kouki, Schmacke, Luna C., Heycke, Nina, Inoue, Asuka, König, Gabriele, Pfeifer, Alexander, Wachten, Dagmar, Schulte, Gunnar, Steinmetzer, Torsten, Watts, Val J., Gomeza, Jesús, Simon, Katharina, Kostenis, Evi

“…A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca 2+ in…”
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