X-linked QTL for knockdown resistance to high temperature in Drosophila melanogaster

Knockdown Resistance to High Temperature (KRHT) is an adaptive trait of thermotolerance in insects. An interval mapping was performed on chromosome X of Drosophila melanogaster to search for quantitative trait loci (QTL) affecting KRHT. A backcross population was obtained from two lines that dramati...

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Bibliographic Details
Published in:	Insect molecular biology Vol. 16; no. 4; pp. 509 - 513
Main Authors:	Norry, F.M, Sambucetti, P, Scannapieco, A.C, Gomez, F.H, Loeschcke, V
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-08-2007 Blackwell Publishing Ltd
Subjects:	Adaptation, Physiological - genetics Animals composite interval mapping Drosophila melanogaster Drosophila melanogaster - genetics environmental stress Female Genes, X-Linked - genetics Genes, X-Linked - physiology heat-knockdown resistance heat-stress resistance Hot Temperature Male Quantitative Trait Loci - genetics sex chromosome sex chromosomes thermal adaptation Time Factors X Chromosome
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Summary:	Knockdown Resistance to High Temperature (KRHT) is an adaptive trait of thermotolerance in insects. An interval mapping was performed on chromosome X of Drosophila melanogaster to search for quantitative trait loci (QTL) affecting KRHT. A backcross population was obtained from two lines that dramatically differ for KRHT. Microsatellites were used as markers. Composite interval mapping identified a large-effect QTL in the region of band 10 where putative candidate genes map. To further test for this QTL a set of recombinant (but non-inbred) lines was obtained from backcrosses between the parental lines used for the interval mapping. Recombinant line analysis confirmed that one QTL is targeted by band 10. We identify and discuss candidate loci contained within our QTL region.
Bibliography:	http://dx.doi.org/10.1111/j.1365-2583.2007.00747.x istex:96FF7D6174301550F4DD53712FB5EBF8F84E76F7 ArticleID:IMB747 ark:/67375/WNG-GC2TQTW7-K ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0962-1075 1365-2583
DOI:	10.1111/j.1365-2583.2007.00747.x