Search Results - "Gomez, Delphine"

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory by Gomez, Delphine, Swiatlowska, Pamela, Owens, Gary K

“…Vascular smooth muscle cells (SMCs), like all cells, acquire a cell-specific epigenetic signature during development that includes acquisition of a unique…”
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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Detection of histone modifications at specific gene loci in single cells in histological sections by Gomez, Delphine, Shankman, Laura S, Nguyen, Anh T, Owens, Gary K

“…A combination of in situ hybridization and a proximity ligation assay allows the visualization of histone modifications at single genomic loci with single-cell…”
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Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective by Cherepanova, Olga A, Gomez, Delphine, Shankman, Laura S, Swiatlowska, Pamela, Williams, Jason, Sarmento, Olga F, Alencar, Gabriel F, Hess, Daniel L, Bevard, Melissa H, Greene, Elizabeth S, Murgai, Meera, Turner, Stephen D, Geng, Yong-Jian, Bekiranov, Stefan, Connelly, Jessica J, Tomilin, Alexey, Owens, Gary K

“…The pluripotency factor OCT4 is expressed in smooth muscle cells of atherosclerotic lesions in both mice and humans, and has atheroprotective effects in mice…”
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Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms by GOMEZ, Delphine, COYET, Aurélie, OLLIVIER, Véronique, JEUNEMAITRE, Xavier, JONDEAU, Guillaume, MICHEL, Jean-Baptiste, VRANCKX, Roger

“…Human thoracic aortic aneurysms (TAAs) are characterized by extracellular matrix breakdown associated with progressive smooth muscle cell (SMC) rarefaction…”
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Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway by Gomez, Delphine, Al Haj Zen, Ayman, Borges, Luciano F, Philippe, Monique, Gutierrez, Paulo Sampaio, Jondeau, Guillaume, Michel, Jean-Baptiste, Vranckx, Roger

“…Common features such as elastic fibre destruction, mucoid accumulation, and smooth muscle cell apoptosis are co-localized in aneurysms of the ascending aorta…”
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Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions by Durgin, Brittany G, Cherepanova, Olga A, Gomez, Delphine, Karaoli, Themistoclis, Alencar, Gabriel F, Butcher, Joshua T, Zhou, Yu-Qing, Bendeck, Michelle P, Isakson, Brant E, Owens, Gary K, Connelly, Jessica J

“…Atherosclerotic plaque rupture with subsequent embolic events is a major cause of sudden death from myocardial infarction or stroke. Although smooth muscle…”
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Faulty Initiation of Proteoglycan Synthesis Causes Cardiac and Joint Defects by Baasanjav, Sevjidmaa, Al-Gazali, Lihadh, Hashiguchi, Taishi, Mizumoto, Shuji, Fischer, Bjoern, Horn, Denise, Seelow, Dominik, Ali, Bassam R., Aziz, Samir A.A., Langer, Ruth, Saleh, Ahmed A.H., Becker, Christian, Nürnberg, Gudrun, Cantagrel, Vincent, Gleeson, Joseph G., Gomez, Delphine, Michel, Jean-Baptiste, Stricker, Sigmar, Lindner, Tom H., Nürnberg, Peter, Sugahara, Kazuyuki, Mundlos, Stefan, Hoffmann, Katrin

“…Proteoglycans are a major component of extracellular matrix and contribute to normal embryonic and postnatal development by ensuring tissue stability and…”
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Smooth muscle cells-specific loss of OCT4 accelerates neointima formation after acute vascular injury by Shin, Junchul, Tkachenko, Svyatoslav, Gomez, Delphine, Tripathi, Rupande, Owens, Gary K, Cherepanova, Olga A

“…There is growing evidence that smooth muscle cell ( ) phenotypic transitions play critical roles during normal developmental and tissue recovery processes and…”
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Smooth muscle cells in atherosclerosis: Clones but not carbon copies by Espinosa-Diez, Cristina, Mandi, Varun, Du, Mingyuan, Liu, Mingjun, Gomez, Delphine

“…Our knowledge of the contribution of vascular smooth muscle cells (SMCs) to atherosclerosis has greatly advanced in the previous decade with the development of…”
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Smooth Muscle Cell Phenotypic Diversity: At the Crossroads of Lineage Tracing and Single-Cell Transcriptomics by Liu, Mingjun, Gomez, Delphine

“…Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and blood distribution, as well as maintaining the structural integrity…”
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Smooth Muscle Cell Phenotypic Diversity by Liu, Mingjun, Gomez, Delphine

“…Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and blood distribution, as well as maintaining the structural integrity…”
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Nobody Is Perfect: Cre Drivers Deserve Careful Consideration by Gomez, Delphine

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miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence by Du, Mingyuan, Espinosa-Diez, Cristina, Liu, Mingjun, Ahmed, Ibrahim Adeola, Mahan, Sidney, Wei, Jianxin, Handen, Adam L., Chan, Stephen Y., Gomez, Delphine

“…miRNAs are versatile regulators of smooth muscle cell (SMC) fate and behavior in vascular development and disease. Targeted loss-of-function studies have…”
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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3 by Bhagwani, Aneel R., Ali, Mehboob, Piper, Bryce, Liu, Mingjun, Hudson, Jaylen, Kelly, Neil, Bogamuwa, Srimathi, Yang, Hu, Londino, James D., Bednash, Joseph S., Farkas, Daniela, Mallampalli, Rama K., Nicolls, Mark R., Ryan, John J., Thompson, A.A. Roger, Chan, Stephen Y., Gomez, Delphine, Goncharova, Elena A., Farkas, Laszlo

“…Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the…”
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Beyond the cytoplasm: nuclear α-actin influences differentiation by Gomez, Delphine

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RNA Methylation: A New Regulator of Vascular Remodeling in Pulmonary Hypertension by Bonnet, Sébastien, Gomez, Delphine

“…Bonnet and Gomez discuss the study by Hu and colleagues which identified a novel epigenetic mechanism, namely RNA methylation, as a driver of vascular…”
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Nuclear Control of Vascular Smooth Muscle Cell Plasticity during Vascular Remodeling by Ahmed, Ibrahim A., Liu, Mingjun, Gomez, Delphine

“…Control of vascular smooth muscle cell (SMC) gene expression is an essential process for establishing and maintaining lineage identity, contractility, and…”
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Smooth muscle cell phenotypic switching in atherosclerosis by Gomez, Delphine, Owens, Gary K

“…Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid adaptation to fluctuating environmental cues, including during…”
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Abstract 76: CASC15 lncRNA as a Mediator of Vascular Senescence in the Renin-Angiotensin System by Cunha, Warlley, Martin, Maria, Ahmed, Ibrahim, Gomez, Delphine, Espinosa-Diez, Cristina

“…Abstract only The renin-angiotensin system (RAS) regulates vascular function and maintains blood pressure homeostasis. Angiotensin-II (Ang-II) and…”
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