Search Results - "Gomes de Paula Queiroz, Rosane"
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Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)
Published in Autoimmunity (Chur, Switzerland) (17-11-2022)“…Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early…”
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2
Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup
Published in Scientific reports (22-04-2020)“…We evaluated the potential effects of ATO in different pediatric SHH-MB cell lines (ONS-76: TP53 -wild type; DAOY and UW402: TP53 -mutated). MB cell lines…”
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3
Musashi-1 regulates cell cycle and confers resistance to cisplatin treatment in Group 3/4 medulloblastomas cells
Published in Human cell : official journal of Human Cell Research Society (01-11-2023)“…Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a…”
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4
Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors
Published in Molecular biology reports (01-08-2020)“…TP53 p.R337H germline mutation is highly prevalent in the Southern region of Brazil. We sought to investigate TP53 p.R337H mutation in pediatric tumor samples…”
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5
Quantitative PCR analysis of the expression profile of genes related to multiple drug resistance in tumors of the central nervous system
Published in Journal of neuro-oncology (01-10-2007)“…To evaluate and compare the profile of expression of genes related to drug resistance in brain tumors and to analyze the impact of the increased expression of…”
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6
Full-house nephropathy associated with high expression of SPATA5L1 due to a genetic pathogenic variant
Published in Rheumatology (Oxford, England) (11-04-2022)Get full text
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Analysis of miR-483-3p and miR-630 expression profile in pediatric adrenocortical tumors and the effect of their modulation on adrenal tumorigenesis in vitro
Published in Molecular and cellular endocrinology (01-12-2024)“…Pediatric adrenocortical tumors (ACT) are rare aggressive neoplasms with heterogeneous prognosis. MicroRNA (miRNA) signatures have been associated with cancer…”
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mRNA expression of matrix metalloproteinases ( MMP s) 2 and 9 and tissue inhibitor of matrix metalloproteinases ( TIMP s) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor
Published in Leukemia research (01-01-2010)“…Abstract This study evaluates the mRNA expression profile of genes TIMP1 , TIMP2 , MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL…”
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9
Higher interferon score and normal complement levels may identify a distinct clinical subset in children with systemic lupus erythematosus
Published in Arthritis research & therapy (25-04-2020)“…Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features…”
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10
A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods
Published in Journal of molecular medicine (Berlin, Germany) (01-08-2021)“…Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need…”
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11
Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma
Published in Neuro-oncology (Charlottesville, Va.) (05-01-2023)“…Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular…”
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12
Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values
Published in Journal of molecular neuroscience (01-03-2022)“…The Group 3 Medulloblastoma (Grp3-MB) is an aggressive molecular subtype with a high incidence of metastasis and deaths. In this study, were used an RNA…”
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13
Clinical Prognostic Implications of Wnt Hub Genes Expression in Medulloblastoma
Published in Cellular and molecular neurobiology (01-03-2023)“…Medulloblastoma is the most common type of pediatric malignant primary brain tumor, and about one-third of patients die due to disease recurrence and most…”
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14
Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia
Published in São Paulo medical journal (01-07-2004)“…Despite the advances in the cure rate for acute lymphoblastic leukemia, approximately 25% of affected children suffer relapses. Expression of genes for the…”
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15
MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals
Published in Genetics and molecular biology (01-01-2009)“…Chromosomal translocations are characteristic of hematopoietic neoplasias and can lead to unregulated oncogene expression or the fusion of genes to yield novel…”
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16
YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells
Published in Cancers (13-12-2021)“…Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype of Sonic…”
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17
Reduced hydroxymethylation characterizes medulloblastoma while TET and IDH genes are differentially expressed within molecular subgroups
Published in Journal of neuro-oncology (01-08-2018)“…Introduction Medulloblastoma (MB) is an embryonal tumour that originates from genetic deregulation of cerebellar developmental pathways and is classified into…”
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18
A simplified approach using Taqman low-density array for medulloblastoma subgrouping
Published in Acta neuropathologica communications (04-03-2019)“…Next-generation sequencing platforms are routinely used for molecular assignment due to their high impact for risk stratification and prognosis in…”
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A new complex rearrangement in infant ALL: t(X;11;17)(p11.2;q23;q12)
Published in Cancer genetics (01-12-2018)“…•MLL rearrangements with involvement of Xp have not been previously described.•We report a novel complex rearrangement t(X;11;17)(p11.2;q23;q12).•Molecular…”
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BUB1 and BUBR1 inhibition decreases proliferation and colony formation, and enhances radiation sensitivity in pediatric glioblastoma cells
Published in Child's nervous system (01-12-2013)“…Purpose Glioblastoma (GBM) is a very aggressive and lethal brain tumor with poor prognosis. Despite new treatment strategies, patients’ median survival is…”
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