Effects of substance use disorder on oxidative and antioxidative stress markers: A systematic review and meta‐analysis

Effects of substance use disorder on oxidative and antioxidative stress markers: A systematic review and meta‐analysis

Recently, it has been suggested that central and peripheral toxicities identified in persons with substance use disorder (SUD) could be partially associated with an imbalance in reactive oxygen species and antioxidant defenses. We conducted a systematic review and meta‐analysis to investigate whethe...

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Bibliographic Details
Published in:Addiction biology Vol. 28; no. 1; pp. e13254 - n/a
Main Authors: Viola, Thiago Wendt, Orso, Rodrigo, Florian, Luisa Fossati, Garcia, Miguel Gomes, Gomes, Marco Giovanni Signor, Mardini, Eduarda Mascarenhas, Niederauer, João Paulo Ottolia, Zaparte, Aline, Grassi‐Oliveira, Rodrigo
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-01-2023
John Wiley and Sons Inc
Subjects:
Aging
Antioxidants
Cannabis
Comorbidity
Drug use
Humans
illicit drugs
Inhalants
Lipid peroxidation
Meta-analysis
Original
Oxidants
Oxidative Stress
Reactive oxygen species
Stimulants
Substance use
Substance use disorder
Substance-Related Disorders
Superoxide dismutase
Systematic review
Thiobarbituric acid
Thiobarbituric Acid Reactive Substances
illicit drugs
meta-analysis
aging
antioxidants
substance-related disorders
oxidative stress
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Summary:Recently, it has been suggested that central and peripheral toxicities identified in persons with substance use disorder (SUD) could be partially associated with an imbalance in reactive oxygen species and antioxidant defenses. We conducted a systematic review and meta‐analysis to investigate whether SUD is associated with oxidative stress and to identify biomarkers possibly more affected by this condition. We have included studies that analysed oxidant and antioxidant markers in individuals with SUD caused by stimulants, alcohol, nicotine, opioids, and others (cannabis, inhalants, and polysubstance use). Our analysis showed that persons with SUD show higher oxidant markers and lower antioxidant markers than healthy controls. SUD was associated specifically with higher levels of oxidant markers malondialdehyde, thiobarbituric acid reactive substances and lipid peroxidation. Conversely, the antioxidant superoxide dismutase and the total antioxidant capacity/status were lowered in the SUD group. A meta‐regression analysis revealed that persons with alcohol use disorder had higher oxidative stress estimates than those with stimulant use disorder. Moreover, individuals evaluated during abstinence showed smaller antioxidant effect sizes than non‐abstinent ones. Our findings suggest a clear oxidative imbalance in persons with SUD, which could lead to cell damage and result in multiple associated comorbidities, particularly accelerated aging. This meta‐analysis found that substance use disorders are related to increased oxidant and reduced antioxidant markers, suggesting a clear oxidative imbalance. Meta‐regressions showed that alcohol use disorder is related to higher oxidative stress estimates in comparison with stimulant use disorder and that individuals on abstinence showed smaller antioxidant effect sizes in comparison with those with current use.
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ISSN:1355-6215
1369-1600
1369-1600
DOI:10.1111/adb.13254