Search Results - "Gomes, Luciana R."
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Autophagy Roles in the Modulation of DNA Repair Pathways
Published in International journal of molecular sciences (07-11-2017)“…Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders…”
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TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells
Published in BMC cancer (19-01-2012)“…Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue…”
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3
Microenvironment and autophagy cross-talk: Implications in cancer therapy
Published in Pharmacological research (01-05-2016)“…[Display omitted] There are many ongoing clinical trials to validate tumour microenvironment or autophagic pathway components as targets for anticancer…”
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Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential
Published in BMC cancer (14-01-2009)“…The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer. The role of matrix…”
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Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation
Published in Autophagy (04-05-2017)“…Chaperone-mediated autophagy (CMA), a selective form of protein lysosomal degradation, is maximally activated in stress situations to ensure maintenance of…”
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A Three-Dimensional Lung Cell Model to Leptospira Virulence Investigations
Published in Current microbiology (01-02-2022)“…Leptospirosis is a worldwide zoonosis and a serious public health threat in tropical and subtropical areas. The etiologic agents of leptospirosis are…”
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RECK is not an independent prognostic marker for breast cancer
Published in BMC cancer (08-10-2015)“…The REversion-inducing Cysteine-rich protein with Kazal motif (RECK) is a well-known inhibitor of matrix metalloproteinases (MMPs) and cellular invasion…”
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DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress
Published in Oxidative medicine and cellular longevity (01-01-2018)“…DUOX1 is an H2O2-generating enzyme related to a wide range of biological features, such as hormone synthesis, host defense, cellular proliferation, and…”
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Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors
Published in Brazilian Journal of Veterinary Pathology (01-11-2021)“…Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their…”
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Abstract A34: Microenvironment controls breast cancer cells sensitivity to doxorubicin by autophagy inhibition
Published in Cancer research (Chicago, Ill.) (01-02-2013)“…Drug chemotherapy resistance is the leading cause of death for cancer patients. Most of the studies involving chemotherapy resistance are based on experiments…”
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Abstract 443: Expression of the RECK tumor and metastasis suppressor gene in human breast cancer: a poor prognosis marker
Published in Cancer research (Chicago, Ill.) (15-04-2012)“…Metastasis is the main cause of mortality in breast cancer human patients. The organized breakdown of the extracellular matrix (ECM) compounds by matrix…”
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Abstract 5266: TGF-β1 modulates the homeostasis between MMPs and MMPs inhibitors through p38 MAPK and ERK½ in highly invasive human breast cancer cells
Published in Cancer research (Chicago, Ill.) (15-04-2011)“…Matrix metalloproteinases (MMPs) and their specific inhibitors, known as tissue inhibitors of MMPs (TIMPs) and the membrane-associated MMP inhibitor (RECK),…”
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TGF-[beta]1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells
Published in BMC cancer (19-01-2012)“…BackgroundMetastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue…”
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