Chlorpromazine-impregnated catheters as a potential strategy to control biofilm-associated urinary tract infections

This study proposes the impregnation of Foley catheters with chlorpromazine (CPZ) to control biofilm formation by , and . The minimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ on biofilm formation were assessed. Afterward, biofilm formation and the effect of ciprofloxacin and me...

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Bibliographic Details
Published in:	Future microbiology Vol. 14; no. 12; pp. 1023 - 1034
Main Authors:	Sidrim, José Jc, Amando, Bruno R, Gomes, Francisco If, do Amaral, Marilia Smg, de Sousa, Paulo Cp, Ocadaque, Crister J, Brilhante, Raimunda Sn, A Cordeiro, Rossana de, Rocha, Marcos Fg, Scm Castelo-Branco, Débora de
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01-08-2019
Subjects:	Anti-Infective Agents - administration & dosage Antimicrobial agents Bacterial infections Biofilms Biofilms - drug effects Biofilms - growth & development catheter impregnation Catheter-Related Infections - prevention & control Catheters Chlorpromazine Chlorpromazine - administration & dosage Ciprofloxacin Drugs E coli efflux-pump inhibitor Enterobacteriaceae Infections - prevention & control Escherichia coli - drug effects Escherichia coli - growth & development Humans Infections Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - growth & development Medical instruments Meropenem Metabolism Microbial Sensitivity Tests Microorganisms Minimum inhibitory concentration Proteus mirabilis - drug effects Proteus mirabilis - growth & development Scanning electron microscopy Urinary Catheterization - methods Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - prevention & control Urine Urogenital system uropathogens uropathogens efflux-pump inhibitor chlorpromazine biofilms catheter impregnation
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Summary:	This study proposes the impregnation of Foley catheters with chlorpromazine (CPZ) to control biofilm formation by , and . The minimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ on biofilm formation were assessed. Afterward, biofilm formation and the effect of ciprofloxacin and meropenem (at MIC) on mature biofilms grown on CPZ-impregnated catheters were evaluated. CPZ MIC range was 39.06–625 mg/l. CPZ significantly reduced (p < 0.05) biofilm formation and on impregnated catheters. In addition, CPZ-impregnation potentiated the antibiofilm activity of ciprofloxacin and meropenem. These findings bring perspectives for the use of CPZ as an adjuvant for preventing and treating catheter-associated urinary tract infections.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1746-0913 1746-0921
DOI:	10.2217/fmb-2019-0092