Search Results - "Gomes, Edgar R"

The role of the cell nucleus in mechanotransduction by Janota, Cátia S., Calero-Cuenca, Francisco Javier, Gomes, Edgar R.

“…Mechanical forces are known to influence cellular processes with consequences at the cellular and physiological level. The cell nucleus is the largest and…”
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Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction by Roman, William, Pinheiro, Helena, Pimentel, Mafalda R, Segalés, Jessica, Oliveira, Luis M, García-Domínguez, Esther, Gómez-Cabrera, Mari Carmen, Serrano, Antonio L, Gomes, Edgar R, Muñoz-Cánoves, Pura

“…Regeneration of skeletal muscle is a highly synchronized process that requires muscle stem cells (satellite cells). We found that localized injuries, as…”
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Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement by Luxton, G.W. Gant, Gomes, Edgar R, Folker, Eric S, Vintinner, Erin, Gundersen, Gregg G

“…Nuclei move to specific locations to polarize migrating and differentiating cells. Many nuclear movements are microtubule-dependent. However, nuclear movement…”
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Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development by Gomes, Edgar R, Marazzi, Giovanna, Mitchell, Kathryn J, Cadot, Bruno, Parlakian, Ara, Sassoon, David A, Besson, Vanessa, Pannérec, Alice

“…In postnatal skeletal muscle, satellite cells are resident myogenic progenitors responsible for muscle growth and regeneration. A distinct population of…”
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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration by Infante, Elvira, Castagnino, Alessia, Ferrari, Robin, Monteiro, Pedro, Agüera-González, Sonia, Paul-Gilloteaux, Perrine, Domingues, Mélanie J., Maiuri, Paolo, Raab, Matthew, Shanahan, Catherine M., Baffet, Alexandre, Piel, Matthieu, Gomes, Edgar R., Chavrier, Philippe

“…Cancer cells’ ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening…”
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Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle by Roman, William, Martins, João P., Carvalho, Filomena A., Voituriez, Raphael, Abella, Jasmine V. G., Santos, Nuno C., Cadot, Bruno, Way, Michael, Gomes, Edgar R.

“…Nuclear movements are important for multiple cellular functions, and are driven by polarized forces generated by motor proteins and the cytoskeleton. During…”
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Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells by Roman, William, Martins, João P., Gomes, Edgar R.

“…Skeletal muscle cells (myofibers) are rod-shaped multinucleated cells surrounded by an extracellular matrix (ECM) basal lamina. In contrast to other cell…”
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Nuclear Movement Regulated by Cdc42, MRCK, Myosin, and Actin Flow Establishes MTOC Polarization in Migrating Cells by Gomes, Edgar R., Jani, Shantanu, Gundersen, Gregg G.

“…The microtubule-organizing center (MTOC) is reoriented between the nucleus and the leading edge in many migrating cells and contributes to directional…”
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Shielding of actin by the endoplasmic reticulum impacts nuclear positioning by Janota, Cátia, Pinto, Andreia, Pezzarossa, Anna, Machado, Pedro, Costa, Judite, Campinho, Pedro, Franco, Claudio, Gomes, Edgar

“…© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction by Fernandes, Andreia R., Martins, João P., Gomes, Edgar R., Mendes, César S., Teodoro, Rita O.

“…Wired neurons form new presynaptic boutons in response to increased synaptic activity, however the mechanism(s) by which this occurs remains uncertain…”
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Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3 by Cadot, Bruno, Gache, Vincent, Vasyutina, Elena, Falcone, Sestina, Birchmeier, Carmen, Gomes, Edgar R

“…Cells actively position their nucleus within the cytoplasm. One striking example is observed during skeletal myogenesis. Differentiated myoblasts fuse to form…”
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Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins by Östlund, Cecilia, Folker, Eric S, Choi, Jason C, Gomes, Edgar R, Gundersen, Gregg G, Worman, Howard J

“…The linker of nucleoskeleton and cytoskeleton (LINC) complex is situated in the nuclear envelope and forms a connection between the lamina and cytoskeletal…”
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Samp1 is a component of TAN lines and is required for nuclear movement by Borrego-Pinto, Joana, Jegou, Thibaud, Osorio, Daniel S, Auradé, Frederic, Gorjánácz, Mátyás, Koch, Birgit, Mattaj, Iain W, Gomes, Edgar R

“…The position of the nucleus is regulated in different developmental stages and cellular events. During polarization, the nucleus moves away from the future…”
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N‐WASP is required for Amphiphysin‐2/BIN1‐dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy by Falcone, Sestina, Roman, William, Hnia, Karim, Gache, Vincent, Didier, Nathalie, Lainé, Jeanne, Auradé, Frederic, Marty, Isabelle, Nishino, Ichizo, Charlet‐Berguerand, Nicolas, Romero, Norma Beatriz, Marazzi, Giovanna, Sassoon, David, Laporte, Jocelyn, Gomes, Edgar

“…© 2014 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution 4.0…”
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Nuclear positioning in skeletal muscle by Roman, William, Gomes, Edgar R.

“…Skeletal muscle cells possess a unique cellular architecture designed to fulfill their contractile function. Muscle cells (also known as myofibers) result from…”
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Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS by Vilmont, Valérie, Cadot, Bruno, Vezin, Elsa, Le Grand, Fabien, Gomes, Edgar R.

“…The neuromuscular junction (NMJ) allows the transformation of a neuronal message into a mechanical force by muscle contraction and is the target of several…”
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Adaptive changes in the DNA damage response during skeletal muscle cell differentiation by Faleiro, Inês, Afonso, Ana I, Balsinha, André, Lucas, Beatriz, Martin, Robert M, Gomes, Edgar R, de Almeida, Sérgio F

“…DNA double-strand breaks (DSBs) trigger specialized cellular mechanisms that collectively form the DNA damage response (DDR). In proliferating cells, the DDR…”
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Fast, multi-dimensional and simultaneous kymograph-like particle dynamics (SkyPad) analysis by Cadot, Bruno, Gache, Vincent, Gomes, Edgar R

“…Kymograph analysis is a method widely used by researchers to analyze particle dynamics in one dimensional (1D) trajectories. Here we provide a Visual…”
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Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing by Evans, Katia J, Gomes, Edgar R, Reisenweber, Steven M, Gundersen, Gregg G, Lauring, Brett P

“…Mutations in the AAA adenosine triphosphatase (ATPase) Spastin (SPG4) cause an autosomal dominant form of hereditary spastic paraplegia, which is a retrograde…”
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Cortical control of microtubule stability and polarization by Gundersen, Gregg G, Gomes, Edgar R, Wen, Ying

“…In both dividing and interphase cells, microtubules are remodeled in response to signal transduction pathways triggered by a variety of stimuli. Members of the…”
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