Effects of a diet enriched with eicosapentaenoic, docosahexaenoic and glutamine on cytokines as immunological markers for systemic inflammation in bitches before and after ovariohysterectomy

The post‐operative period can generate immunological stress and can be modulated through supplementation with the omega‐3 series of polyunsaturated fatty acids. This study aimed to evaluate the effects of diets enriched with high doses of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids and gl...

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Published in:	Journal of animal physiology and animal nutrition Vol. 105; no. S2; pp. 79 - 88
Main Authors:	Porsani, Mariana Y. H., Bonder, Brana S. A., Teixeira, Fabio A., Gomes, Cristina O. M. S., Gonçales, Lucas A., Nagashima, Julio K., Balieiro, Julio C. C., Fantoni, Denise T., Pontieri, Cristiana F. F., Jeremias, Juliana T., Brunetto, Marcio A.
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-11-2021
Subjects:	Age factors Animals Body composition Body fat Body weight canine Cytokines Cytokines - blood Diet Diet - veterinary docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Dog Diseases Dogs eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Enrichment Evaluation Fatty acids Female fish oil Fish Oils Glutamine Glutamine - administration & dosage Hysterectomy - veterinary Immunology Inflammation Inflammation - veterinary Insulin-like growth factors Lymphocytes Markers Ovariectomy - veterinary ovariohysterectomy Polyunsaturated fatty acids Statistical analysis Surgery Tumor necrosis factor ovariohysterectomy eicosapentaenoic acid canine docosahexaenoic acid fish oil
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Summary:	The post‐operative period can generate immunological stress and can be modulated through supplementation with the omega‐3 series of polyunsaturated fatty acids. This study aimed to evaluate the effects of diets enriched with high doses of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids and glutamine on inflammatory mediators in dogs before and after ovariohysterectomy (OVH). Twelve female dogs were divided into two groups: group A was fed a commercial diet without the addition of EPA and DHA, and group B was fed an experimental diet enriched with EPA and DHA (0.2 g/100 kcal). Experimental diet intake initiated 21 days before surgery and continued until 30 days after OVH. Parameters measured were serum cytokines (TNF‐α, IL‐6 and IL‐10), C‐reactive protein (CRP), IGF‐1, lymphoproliferation and body composition before and after surgery. Statistical analyses were performed with SAS software considering the effects of age and diet and their interactions, and means were compared by the Tukey test. There was no difference between groups in body weight (p = .682), lean mass (p = .101) and body fat (p = .103). There were no group differences in serum concentrations of TNF‐α, IL‐6, IL‐10, IGF‐1, CRP and the percentage of lymphocyte proliferation. However, a time effect for TNF‐α was observed (p < .001), in which T0P (10 days after the surgical procedure) presented lower values of this cytokine when compared to the other evaluation time points; and interaction effects between group and time were observed for serum concentrations of IL‐6 (p < .001) and IL‐10 (p = .002). OVH procedure was not considered invasive enough to increase inflammatory cytokines after 30 days of surgery, as well as the dosage of the EPA and DHA used before and after the surgery did not modulate the inflammatory markers.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0931-2439 1439-0396
DOI:	10.1111/jpn.13196