Search Results - "Gomes, Catarina A."

Microglia sequelae: brain signature of innate immunity in schizophrenia by Rodrigues-Neves, A. Catarina, Ambrósio, António. F., Gomes, Catarina A.

“…Schizophrenia is a psychiatric disorder with significant impact on individuals and society. The current pharmacologic treatment, which principally alleviates…”
Get full text

Depression as a Glial-Based Synaptic Dysfunction by Rial, Daniel, Lemos, Cristina, Pinheiro, Helena, Duarte, Joana M, Gonçalves, Francisco Q, Real, Joana I, Prediger, Rui D, Gonçalves, Nélio, Gomes, Catarina A, Canas, Paula M, Agostinho, Paula, Cunha, Rodrigo A

“…Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive…”
Get full text

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism by George, Jimmy, Gonçalves, Francisco Q., Cristóvão, Gonçalo, Rodrigues, Lisa, Meyer Fernandes, José Roberto, Gonçalves, Teresa, Cunha, Rodrigo A., Gomes, Catarina A.

“…Microglia rely on their ability to proliferate in the brain parenchyma to sustain brain innate immunity and participate in the reaction to brain damage. We now…”
Get full text

Neonatal testosterone voids sexually differentiated microglia morphology and behavior by Simões-Henriques, Carla Filipa, Rodrigues-Neves, A Catarina, Sousa, Fábio J, Gaspar, Rita, Almeida, Inês, Baptista, Filipa I, Ambrósio, António F, Gomes, Catarina A

“…The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to…”
Get full text

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia by Gaspar, Rita, Soares-Cunha, Carina, Domingues, Ana Verónica, Coimbra, Bárbara, Baptista, Filipa I, Pinto, Luísa, Ambrósio, António F, Rodrigues, Ana João, Gomes, Catarina A

“…Stress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that…”
Get full text

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies by Baptista, Filipa I., Pinheiro, Helena, Gomes, Catarina A., Ambrósio, António F.

“…Diabetes mellitus is a chronic disease with numerous complications that severely impact on the quality of life of patients. Different neuropathies may arise as…”
Get full text

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia by Gaspar, Rita, Soares-Cunha, Carina, Domingues, Ana Verónica, Coimbra, Bárbara, Baptista, Filipa I., Pinto, Luísa, Ambrósio, António F., Rodrigues, Ana João, Gomes, Catarina A.

“…Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the…”
Get full text

Role of Microglia Adenosine A_(2A) Receptors in Retinal and Brain Neurodegenerative Diseases by Santiago, Ana R, Baptista, Filipa I, Santos, Paulo F, Cristovao, Goncalo, Ambrosio, Antonio F, Cunha, Rodrigo A, Gomes, Catarina A

“…Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases. Whether this microglia-mediated…”
Get full text

Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin:  A Structure−Activity Study by Gomes, Catarina A, Girão da Cruz, Teresa, Andrade, José L, Milhazes, Nuno, Borges, Fernanda, Marques, M. Paula M

“…Several phenolic acidscaffeic and gallic acid derivativeswere synthesized and screened for their potential antiproliferative and cytotoxic properties, in…”
Get full text

Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy by Sousa, Fábio J., Correia, Raquel G., Cruz, Alexandra F., Martins, Joana M., Rodrigues, Matilde S., Gomes, Catarina A., Ambrósio, António F., Baptista, Filipa I.

“…Diabetes during pregnancy has been shown to affect the central nervous system (CNS) of the offspring, resulting in short- and long-term adverse effects…”
Get full text

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons by Pinheiro, Helena, Gaspar, Rita, Baptista, Filipa I., Fontes-Ribeiro, Carlos A., Ambrósio, António F., Gomes, Catarina A.

“…The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the…”
Get full text

Activation of microglia bolsters synapse formation by Cristovão, Gonçalo, Pinto, Maria J, Cunha, Rodrigo A, Almeida, Ramiro D, Gomes, Catarina A

“…Exp. Neurol. 250, 176–188. doi: 10.1016/j.expneurol.2013.09.005 Microglial cells in the central nervous system (CNS) are major players of innate immunity, the…”
Get full text

GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A₂A receptors by Gomes, Catarina A.R.V, Simões, Patrícia F, Canas, Paula M, Quiroz, César, Sebastião, Ana M, Ferré, Sergi, Cunha, Rodrigo A, Ribeiro, Joaquim A

“…Glial cell line-derived neurotrophic factor (GDNF) affords neuroprotection in Parkinson's disease in accordance with its ability to bolster nigrostriatal…”
Get full text

Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: Brain region and sex specificities by Simões-Henriques, Carla, Mateus‐Pinheiro, Miguel, Gaspar, Rita, Pinheiro, Helena, Mendes Duarte, Joana, Baptista, Filipa I., Canas, Paula M., Fontes-Ribeiro, Carlos Alberto, Cunha, Rodrigo A., Ambrósio, António F., Gomes, Catarina A.

“…Microglia cells exert a critical role in brain development, mainly supported by their immune functions, which predicts an impact on the genesis of psychiatric…”
Get full text

Region-specific control of microglia by adenosine A 2A receptors: uncoupling anxiety and associated cognitive deficits in female rats by Duarte, Joana Mendes, Gaspar, Rita, Caetano, Liliana, Patrício, Patrícia, Soares-Cunha, Carina, Mateus-Pinheiro, António, Alves, Nuno Dinis, Santos, Ana Rita, Ferreira, Samira G, Sardinha, Vanessa, Oliveira, João Filipe, Fontes-Ribeiro, Carlos, Sousa, Nuno, Cunha, Rodrigo A, Ambrósio, António F, Pinto, Luísa, Rodrigues, Ana João, Gomes, Catarina A

“…Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with…”
Get full text

Unravelling the origin of Vitis vinifera L. Verdelho by Moita Maçanita, A., Santos, R., Catarina Gomes, A.

“…Background and Aims The history of Vitis vinifera L. cv. Verdelho has been studied, however, its geographic origin remains unknown. Although not widespread in…”
Get full text

Sex‐specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress by Ferreira, Ana Sofia, Galvão, Sofia, Gaspar, Rita, Rodrigues‐Neves, Ana C., Ambrósio, António F., Matafome, Paulo, Gomes, Catarina A., Baptista, Filipa I.

“…Background Prenatal stress is associated with increased susceptibility to psychiatric and metabolic disorders later in life. Prenatal exposure to stress…”
Get full text

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses by Machado, Nuno J., Simões, Ana Patrícia, Silva, Henrique B., Ardais, Ana Paula, Kaster, Manuella P., Garção, Pedro, Rodrigues, Diana I., Pochmann, Daniela, Santos, Ana Isabel, Araújo, Inês M., Porciúncula, Lisiane O., Tomé, Ângelo R., Köfalvi, Attila, Vaugeois, Jean-Marie, Agostinho, Paula, El Yacoubi, Malika, Cunha, Rodrigo A., Gomes, Catarina A.

“…Caffeine prophylactically prevents mood and memory impairments through adenosine A 2A receptor (A 2A R) antagonism. A 2A R antagonists also therapeutically…”
Get full text

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A Receptor in Hippocampal Glutamate Synapses by Machado, Nuno J, Simões, Ana Patrícia, Silva, Henrique B, Ardais, Ana Paula, Kaster, Manuella P, Garção, Pedro, Rodrigues, Diana I, Pochmann, Daniela, Santos, Ana Isabel, Araújo, Inês M, Porciúncula, Lisiane O, Tomé, Ângelo R, Köfalvi, Attila, Vaugeois, Jean-Marie, Agostinho, Paula, El Yacoubi, Malika, Cunha, Rodrigo A, Gomes, Catarina A

“…Caffeine prophylactically prevents mood and memory impairments through adenosine A receptor (AR) antagonism. AR antagonists also therapeutically revert mood…”
Get full text

Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: Brain region and sex specificities by Simões-Henriques, Carla, Mateus-Pinheiro, Miguel, Gaspar, Rita, Pinheiro, Helena, Mendes Duarte, Joana, Baptista, Filipa I, Canas, Paula M, Fontes-Ribeiro, Carlos Alberto, Cunha, Rodrigo A, Ambrósio, António F, Gomes, Catarina A

“…Microglia cells exert a critical role in brain development, mainly supported by their immune functions, which predicts an impact on the genesis of psychiatric…”
Get full text