Search Results - "Gomer, Charles"

Paul K Strudler: The Oracle of RAD by Kessel, David, Gomer, Charles J., Hasan, Tayyaba

“…Paul Strudler who facilitated the support of photodynamic therapy by an NIH study section…”
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Targeting the 90 kDa heat shock protein improves photodynamic therapy by Ferrario, Angela, Gomer, Charles J

“…Abstract The geldanamycin derivative, 17-allylamino-17-demethoxygeldanamycin (17-AAG), binds to the amino-terminal ATP binding pocket of the 90 kDa heat shock…”
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Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response by FERRARIO, Angela, RUCKER, Natalie, WONG, Sam, LUNA, Marian, GOMER, Charles J

“…We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human…”
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Induction of prosurvival molecules during treatment: rethinking therapy options for photodynamic therapy by Gomer, Charles J

“…Photodynamic therapy (PDT) not only causes direct cytotoxicity to malignant cells within a tumor but also appears to have both direct and indirect effects on…”
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Targeting Survivin Enhances Chemosensitivity in Retinoblastoma Cells and Orthotopic Tumors by Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam, Lederman, Ariel, Kim, Jonathan, Gomer, Charles

“…Treatments for retinoblastoma (Rb) vary depending on the size and location of the intraocular lesions and include chemotherapy and radiation therapy. We…”
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Photodynamic therapy: Combined modality approaches targeting the tumor microenvironment by Gomer, Charles J., Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam

“…Background and Objectives Photodynamic therapy causes direct cytotoxicity to malignant cells within a tumor. Photodynamic therapy (PDT) can also have both…”
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Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors by Coricello, Adriana, El-Magboub, Asma, Luna, Marian, Ferrario, Angela, Haworth, Ian S., Gomer, Charles J., Aiello, Francesca, Adams, James D.

“…[Display omitted] Sesquiterpene compounds are widely known for their numerous pharmacological activities. Herein the focus of the authors was on α-Santonin, a…”
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Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors by FERRARIO, Angela, FISHER, Anita M, RUCKER, Natalie, GOMER, Charles J

“…Photodynamic therapy (PDT) elicits both apoptotic and necrotic responses within treated tumors and produces microvascular injury leading to inflammation and…”
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Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression by Perri, Filomena, Frattaruolo, Luca, Haworth, Ian, Brindisi, Matteo, El-magboub, Asma, Ferrario, Angela, Gomer, Charles, Aiello, Francesca, Adams, James David

“…Plants of the Asteraceae family have been used in traditional medicine for centuries due to their main antimicrobial and analgesic activities. A liniment from…”
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Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response by FERRARIO, Angela, VON TIEHL, Karl, WONG, Sam, LUNA, Marian, GOMER, Charles J

“…Photodynamic therapy (PDT) continues to be used in the treatment of solid tumors. Clinical results are promising, but the therapy has not been optimized, and…”
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Pro-apoptotic and anti-inflammatory properties of the green tea constituent epigallocatechin gallate increase photodynamic therapy responsiveness by Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam, Gomer, Charles J.

“…Background A polyphenol constituent of green tea, epigallocatechin gallate (EGCG), has anti‐carcinogenic properties. A growing number of studies document…”
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Avastin enhances photodynamic therapy treatment of Kaposi's sarcoma in a mouse tumor model by Ferrario, Angela, Gomer, Charles J

“…The goal of the current study was to determine if the antiangiogenic drug Avastin would improve the effectiveness of Photodynamic Therapy (PDT) in a xenograft…”
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Photodynamic Therapy by Dougherty, Thomas J., Gomer, Charles J., Jori, Giulio, Kessel, David, Korbelik, Mladen, Moan, Johan, Peng, Qian

“…Photodynamic therapy involves administration of a tumorlocalizing photosensitizing agent, which may require metabolic synthesis (i.e., a prodrug), followed by…”
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Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib by Ferrario, Angela, Lim, Sophia, Xu, Frank, Luna, Marian, Gaffney, Kevin J, Petasis, Nicos A, Schönthal, Axel H, Gomer, Charles J

“…Abstract Photodynamic therapy (PDT) effectiveness can be improved by employing combined modality approaches involving pharmaceuticals targeting the tumor…”
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Targeting the 90kDa heat shock protein improves photodynamic therapy by Ferrario, Angela, Gomer, Charles J.

“…The geldanamycin derivative, 17-allylamino-17-demethoxygeldanamycin (17-AAG), binds to the amino-terminal ATP binding pocket of the 90kDa heat shock protein…”
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The matrix metalloproteinase inhibitor Prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model by FERRARIO, Angela, CHANTRAIN, Christophe F, VON TIEHL, Karl, BUCKLEY, Sue, RUCKER, Natalie, SHALINSKY, David R, SHIMADA, Hiroyuki, DECLERCK, Yves A, GOMER, Charles J

“…Photodynamic therapy (PDT) clinical results are promising; however, tumor recurrences can occur and, therefore, methods for improving treatment efficacy are…”
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Cyclooxygenase-2 Expression Induced by Photofrin Photodynamic Therapy Involves the p38 MAPK Pathway by Luna, Marian, Wong, Sam, Ferrario, Angela, Gomer, Charles J.

“…Photodynamic therapy (PDT), using the porphyrin photosensitizer Photofrin (PH), is approved for the clinical treatment of solid tumors. In addition to the…”
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Corrigendum to “Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression” [Heliyon 5 (3) (March 2019) e01366] by Perri, Filomena, Frattaruolo, Luca, Haworth, Ian, Brindisi, Matteo, El-magboub, Asma, Ferrario, Angela, Gomer, Charles, Aiello, Francesca, Adams, James David

“…[This corrects the article DOI: 10.1016/j.heliyon.2019.e01366.]…”
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Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines by KESHELAVA, Nino, ZUO, Juan J, PING CHEN, WAIDYARATNE, Sitara N, LUNA, Marian C, GOMER, Charles J, TRICHE, Timothy J, REYNOLDS, C. Patrick

“…Neuroblastomas can acquire a sustained high-level drug resistance during chemotherapy and especially myeloablative chemoradiotherapy. p53 mutations are rare in…”
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Multiple Components of Photodynamic Therapy Can Phosphorylate Akt by Bozkulak, Ozguncem, Wong, Sam, Luna, Marian, Ferrario, Angela, Rucker, Natalie, Gulsoy, Murat, Gomer, Charles J.

“…A growing number of clinically relevant molecular and cellular responses are observed following photodynamic therapy (PDT). PDT‐mediated oxidative stress and…”
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