Search Results - "Gombotz, Wayne R."

Evaluation of Temperature-Sensitive, Indocyanine Green-Encapsulating Micelles for Noninvasive Near-Infrared Tumor Imaging by Kim, Tae Hee, Chen, Yongping, Mount, Christopher W, Gombotz, Wayne R, Li, Xingde, Pun, Suzie H

“…Purpose Indocyanine green (ICG), an FDA-approved near infrared (NIR) dye, has potential application as a contrast agent for tumor detection. Because ICG binds…”
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Protein release from alginate matrices by Gombotz, Wayne R., Wee, Siow Fong

“…There are a variety of both natural and synthetic polymeric systems that have been investigated for the controlled release of proteins. Many of the procedures…”
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Filamentous, Mixed Micelles of Triblock Copolymers Enhance Tumor Localization of Indocyanine Green in a Murine Xenograft Model by Kim, Tae Hee, Mount, Christopher W, Dulken, Benjamin W, Ramos, Jenelyn, Fu, Caroline J, Khant, Htet A, Chiu, Wah, Gombotz, Wayne R, Pun, Suzie H

“…Polymeric micelles formed by the self-assembly of amphiphilic block copolymers can be used to encapsulate hydrophobic drugs for tumor-delivery applications…”
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The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles by Kim, Tae-Hee, Mount, Christopher W, Gombotz, Wayne R, Pun, Suzie H

“…Abstract Doxorubicin (DOX) is an effective chemotherapeutic against a wide range of solid tumors. However, its clinical use is limited by severe side effects…”
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Design of a titering assay for lentiviral vectors utilizing direct extraction of DNA from transduced cells in microtiter plates by Murphy, Michele E, Vin, Chintan D, Slough, Megan M, Gombotz, Wayne R, Kelley-Clarke, Brenna

“…Using lentiviral vector products in clinical applications requires an accurate method for measuring transduction titer. For vectors lacking a marker gene,…”
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Development of a replication-competent lentivirus assay for dendritic cell-targeting lentiviral vectors by Farley, Daniel C, McCloskey, Laura, Thorne, Barbara A, Tareen, Semih U, Nicolai, Christopher J, Campbell, David J, Bannister, Richard, Stewart, Hannah J, Pearson, Laura Je, Moyer, Bentley J, Robbins, Scott H, Zielinski, Leah, Kim, Tae, Radcliffe, Pippa A, Mitrophanous, Kyriacos A, Gombotz, Wayne R, Miskin, James E, Kelley-Clarke, Brenna

“…It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use…”
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Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry by REMMELE, R. L, NIGHTLINGER, N. S, SRINIVASAN, S, GOMBOTZ, W. R

“…To elucidate the solution conditions that confer stability of aqueous IL-1R using differential scanning calorimetry (DSC). Optimal pH conditions were…”
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Protein release from alginate matrices by Gombotz, Wayne R, Wee, SiowFong

“…There are a variety of both natural and synthetic polymeric systems that have been investigated for the controlled release of proteins. Many of the procedures…”
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Physical Characterization and Stabilization of a Lentiviral Vector Against Adsorption and Freeze-Thaw by Kumru, Ozan S, Wang, Yu, Gombotz, C Wayne R, Kelley-Clarke, Brenna, Cieplak, Witold, Kim, Tae, Joshi, Sangeeta B, Volkin, David B

“…A replication-deficient lentiviral vector encoding the tumor antigen gene NY-ESO-1 was characterized in terms of vector morphology, particle size range,…”
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Biodegradable Polymers for Protein and Peptide Drug Delivery by Gombotz, Wayne R, Pettit, Dean K

“…We have reviewed a large cross-section of degradable polymeric delivery systems for protein and peptide pharmaceuticals. These systems include monolithic type…”
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Correction to “Filamentous, Mixed Micelles of Triblock Copolymers Enhance Tumor Localization of Indocyanine Green in a Murine Xenograft Model” by Kim, Tae Hee, Mount, Christopher W, Dulken, Benjamin W, Ramos, Jenelyn, Fu, Caroline J, Khant, Htet A, Chiu, Wah, Gombotz, Wayne R, Pun, Suzie H

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Release of PEGylated granulocyte-macrophage colony-stimulating factor from chitosan/glycerol films by Brown, Chad D, Kreilgaard, Lotte, Nakakura, Masashi, Caram-Lelham, Ninus, Pettit, Dean K, Gombotz, Wayne R, Hoffman, Allan S

“…We have prepared a new formulation for mucosal delivery of GM-CSF or PEGylated GM-CSF based on a chitosan carrier plus added glycerol to control the rate of…”
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The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals by Pettit, Dean K, Gombotz, Wayne R

“…The desire to deliver protein and peptide biopharmaceuticals conveniently and effectively has led to intense investigation of site-specific drug-delivery…”
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Structure-Function Studies of Interleukin 15 using Site-specific Mutagenesis, Polyethylene Glycol Conjugation, and Homology Modeling by Pettit, Dean K., Bonnert, Timothy P., Eisenman, June, Srinivasan, Subhashini, Paxton, Ray, Beers, Courtney, Lynch, Dave, Miller, Bob, Yost, Jeff, Grabstein, Kenneth H., Gombotz, Wayne R.

“…Interleukin (IL)-15 is a multifunctional cytokine that shares many biological activities with IL-2. This functional overlap, as well as receptor binding…”
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Minimization of Recombinant Human Flt3 Ligand Aggregation at the T m Plateau:  A Matter of Thermal Reversibility by Remmele, Richard L, Bhat, Saraswaty D, Phan, Duke H, Gombotz, Wayne R

“…This study elucidates the importance of thermal reversibility as it pertains to the minimization of recombinant human Flt3 ligand aggregation and its potential…”
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The enhancement in wound healing by transforming growth factor-β1 (TGF-β1) depends on the topical delivery system by PUOLAKKAINEN, P. A, TWARDZIK, D. R, RANCHALIS, J. E, PANKEY, S. C, REED, M. J, GOMBOTZ, W. R

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Abstract 5919: Component-specific qPCR assays for characterization and identity testing of multigenome ZVex®, a dendritic cell-targeting lentiviral vector platform by Bajaj, Anshika, Lin, Tsai-Yu, Ngo, Lisa Y., Murphy, Michele, Kelley-Clarke, Brenna, Gombotz, Wayne R., Meulen, Jan H. ter, Berglund, Peter

“…Background: ZVex is a novel, integration-deficient, dendritic cell-targeting lentiviral vector platform currently being evaluated in clinical trials in sarcoma…”
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Characterization of the isoforms of PIXY321, a granulocyte-macrophage-colony stimulating factor–interleukin-3 fusion protein, separated by preparative isoelectric focusing on immobilized pH gradients by Balland, Alain, Mahan-Boyce, Julia A, Krasts, Dace A, Daniels, Mark, Wang, Wesley, Gombotz, Wayne R

“…We present here the purification and the characterization of the isoforms of PIXY321, a genetically engineered fusion of granulocyte-macrophage-colony…”
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Minimization of Recombinant Human Flt3 Ligand Aggregation at the Tm Plateau:  A Matter of Thermal Reversibility by REMMELE, Richard L., BHAT, Saraswaty D., PHAN, Duke H., GOMBOTZ, Wayne R.

“…This study elucidates the importance of thermal reversibility as it pertains to the minimization of recombinant human Flt3 ligand aggregation and its potential…”
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Protein adsorption to poly(ethylene oxide) surfaces by Gombotz, W R, Wang, G H, Horbett, T A, Hoffman, A S

“…Surfaces containing poly(ethylene oxide) (PEO) are interesting biomaterials because they exhibit low degrees of protein adsorption and cell adhesion. In this…”
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