Search Results - "Gomariz, R P"

VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts by Gutiérrez-Cañas, I., Juarranz, Y., Santiago, B., Arranz, A., Martinez, C., Galindo, M., Payá, M., Gomariz, R. P., Pablos, J. L.

“…Objectives. Vasoactive intestinal peptide (VIP) has demonstrated therapeutic effects in arthritis by inhibiting both innate and acquired immune responses. We…”
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Vasoactive intestinal peptide modulates proinflammatory mediator synthesis in osteoarthritic and rheumatoid synovial cells by Juarranz, M. G., Santiago, B., Torroba, M., Gutierrez-Cañas, I., Palao, G., Galindo, M., Abad, C., Martinez, C., Leceta, J., Pablos, J. L., Gomariz, R. P.

“…Objective. Vasoactive intestinal peptide (VIP) has demonstrated beneficial effects in several murine models of immune-mediated inflammation by inhibiting both…”
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Immunology of VIP: a review and therapeutical perspectives by Gomariz, R P, Martinez, C, Abad, C, Leceta, J, Delgado, M

“…Vasoactive intestinal peptide (VIP) is a neuropeptide with a broad distribution in the body that exerts very important pleiotropic functions in several…”
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Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases by DELGADO, M, ABAD, C, MARTINEZ, C, JUARRANZ, M. G, ARRANZ, A, GOMARIZ, R. P, LECETA, J

“…Vasoactive intestinal peptide (VIP), a neuropeptide that is produced by lymphoid as well as neural cells, exerts a wide spectrum of immunological functions,…”
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Defective signalling in salivary glands precedes the autoimmune response in the non‐obese diabetic mouse model of sialadenitis by Rosignoli, F., Roca, V., Meiss, R., Leceta, J., Gomariz, R. P., Pérez Leirós, C.

“…Summary The spontaneous non‐obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the…”
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Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients by Villanueva-Romero, R., Gutiérrez-Cañas, I., Carrión, M., González-Álvaro, I., Rodríguez-Frade, J. M., Mellado, M., Martínez, C., Gomariz, R. P., Juarranz, Y.

“…Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4 + cells in normal and pathological conditions, which exerts its anti-inflammatory…”
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Induction of neuropeptide gene expression and blockade of retrograde transport in facial motor neurons following local peripheral nerve inflammation in severe combined immunodeficiency and BALB/C mice by Armstrong, B.D., Hu, Z., Abad, C., Yamamoto, M., Rodriguez, W.I., Cheng, J., Lee, M., Chhith, S., Gomariz, R.P., Waschek, J.A.

“…Peripheral nerve inflammation is a common clinical problem that accompanies nerve injury and several diseases including Guillain-Barré syndrome and acute and…”
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VIP-PACAP system in immunity: new insights for multitarget therapy by Gomariz, R P, Juarranz, Y, Abad, C, Arranz, A, Leceta, J, Martinez, C

“…Our research about VIP/PACAP and the immune system goes back to 1990 when our group described the expression of VIP on lymphocytes for the first time. Since…”
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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide modulate endotoxin-induced IL-6 production by murine peritoneal macrophages by Martínez, Carmen, Delgado, Mario, Pozo, David, Leceta, Javier, Calvo, Juan R., Ganea, Doina, Gomariz, Rosa P.

“…Vasoactive intestinal peptide (VIP) is a neuropeptide synthesized by immune cells that can modulate several immune aspects, including the function of cells…”
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Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Collagen-Induced Arthritis: An Experimental Immunomodulatory Therapy by Abad, Catalina, Martinez, Carmen, Leceta, Javier, Gomariz, Rosa P, Delgado, Mario

“…Rheumatoid arthritis is a chronic, systemic, autoimmune, and inflammatory disorder that affects the synovial lining of the joints. We describe the beneficial…”
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Biomarkers predicting a need for intensive treatment in patients with early arthritis by González-Álvaro, I, Ortiz, A M, Seoane, I V, García-Vicuña, R, Martínez, C, Gomariz, R P

“…The heterogeneous nature of rheumatoid arthritis (RA) complicates early recognition and treatment. In recent years, a growing body of evidence has demonstrated…”
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Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease by Delgado, Mario, Abad, Catalina, Martinez, Carmen, Leceta, Javier, Gomariz, Rosa P

“…Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease of unknown etiology, characterized by chronic inflammation in the joints and…”
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Regulation of TLR expression, a new perspective for the role of VIP in immunity by Gomariz, R.P., Arranz, A., Juarranz, Y., Gutierrez-Cañas, I., Garcia-Gomez, M., Leceta, J., Martínez, C.

“…The contribution of VIP immune functions to the regulation of homeostasis and health is well known. Modulation of immune responses through new therapeutics is…”
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VIP and Tolerance Induction in Autoimmunity by ROSIGNOLI, F., TORROBA, M., JUARRANZ, Y., GARCÍA-GÓMEZ, M., MARTINEZ, C., GOMARIZ, R.P., PÉREZ-LEIRÓS, C., LECETA, J.

“…:  Vasoactive intestinal peptide (VIP) is a potent anti‐inflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of…”
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VIP gene expression in rat thymus and spleen by Gomariz, R P, Delgado, M, Naranjo, J R, Mellström, B, Tormo, A, Mata, F, Leceta, J

“…Vasoactive intestinal peptide (VIP) is a neuropeptide with immunomodulatory properties. In the present study, we demonstrate VIP gene expression in cells of…”
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Pituitary adenylate cyclase-activating polypeptide (PACAP38) modulates lymphocyte and macrophage functions: stimulation of adherence and opposite effect on mobility by Garrido, E, Delgado, M, Martínez, C, Gomariz, R.P, Fuente, M.De la

“…The effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) in a concentration range from 10 −13 to 10 −6 M were studied, in vitro, on two…”
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Vasoactive intestinal peptide as a healing mediator in Crohn's disease by Arranz, A, Abad, C, Juarranz, Y, Leceta, J, Martinez, C, Gomariz, R P

“…The vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide (VIP/PACAP) system is considered as a paradigm for the use of a…”
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VIP Decreases TLR4 Expression Induced by LPS and TNF-α Treatment in Human Synovial Fibroblasts by JUARRANZ, Y., GUTIÉRREZ-CAÑAS, I., ARRANZ, A., MARTÍNEZ, C., ABAD, C., LECETA, J., PABLOS, J.L., GOMARIZ, R.P.

“…:  It has been demonstrated that VIP produces beneficial effects both in a murine model of rheumatoid arthritis and in human rheumatoid synovial fibroblasts…”
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Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP by Gomariz, Rosa P., Arranz, Alicia, Abad, Catalina, Torroba, Marta, Martinez, Carmen, Rosignoli, Florencia, Garcia‐Gómez, Maria, Leceta, Javier, Juarranz, Yasmina

“…Toll‐like receptor 2 (TLR2) and ‐4 mediate signals from a great variety of bacterial gut products, giving the host a panel of microbe‐recognizing receptors…”
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Characterization of gene expression of VIP and VIP1-receptor in rat peritoneal lymphocytes and macrophages by Delgado, Mario, Pozo, David, Martinez, Carmen, Garrido, Elvira, Leceta, Javier, Calvo, Juan R., Gomariz, Rosa P.

“…In the present report we show the gene expression pattern of VIP and VIP1 receptor in two peritoneal cell populations, macrophages and lymphocytes by reverse…”
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