Search Results - "Gomari, Mohammad Mahmoudi"

Targeting siRNA in colorectal cancer therapy: Nanotechnology comes into view by Aghamiri, Shahin, Jafarpour, Ali, Malekshahi, Ziba Veisi, Mahmoudi Gomari, Mohammad, Negahdari, Babak

“…Colorectal cancer (CRC) is known as one of the most important causes of death and mortality worldwide. Although several efforts have been made for finding new…”
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Opportunities and challenges of the tag-assisted protein purification techniques: Applications in the pharmaceutical industry by Mahmoudi Gomari, Mohammad, Saraygord-Afshari, Neda, Farsimadan, Marziye, Rostami, Neda, Aghamiri, Shahin, Farajollahi, Mohammad M.

“…Tag-assisted protein purification is a method of choice for both academic researches and large-scale industrial demands. Application of the purification tags…”
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The role of S477N mutation in the molecular behavior of SARS‐CoV‐2 spike protein: An in‐silico perspective by Mondeali, Mozhgan, Etemadi, Ali, Barkhordari, Khabat, Mobini Kesheh, Mina, Shavandi, Sara, Bahavar, Atefeh, Tabatabaie, Fatemeh Hosseini, Mahmoudi Gomari, Mohammad, Modarressi, Mohammad H.

“…The attachment of SARA‐CoV‐2 happens between ACE2 and the receptor binding domain (RBD) on the spike protein. Mutations in this domain can affect the binding…”
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Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review by Choupani, Edris, Mahmoudi Gomari, Mohammad, Zanganeh, Saeed, Nasseri, Sherko, Haji-Allahverdipoor, Kaveh, Rostami, Neda, Hernandez, Yaeren, Najafi, Safa, Saraygord-Afshari, Neda, Hosseini, Arshad

“…Among different types of breast cancers (BC), triple-negative BC (TNBC) amounts to 15% to 20% of breast malignancies. Three principal characteristics of TNBC…”
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Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics study by Mahmoudi Gomari, Mohammad, Rostami, Neda, Omidi-Ardali, Hossein, Arab, Seyed Shahriar

“…Undoubtedly, the SARS-CoV-2 has become a major concern for all societies due to its catastrophic effects on public health. In addition, mutations and changes…”
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Rational peptide design for targeting cancer cell invasion by Gomari, Mohammad Mahmoudi, Arab, Seyed Shahriar, Balalaie, Saeed, Ramezanpour, Sorour, Hosseini, Arshad, Dokholyan, Nikolay V., Tarighi, Parastoo

“…Cell invasion is an important process in cancer progression and recurrence. Invasion and implantation of cancer cells from their original place to other…”
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Evaluation of pH change effects on the HSA folding and its drug binding characteristics, a computational biology investigation by Gomari, Mohammad Mahmoudi, Rostami, Neda, Faradonbeh, Davood Rabiei, Asemaneh, Hamid Reza, Esmailnia, Giti, Arab, Shahriar, Farsimadan, Marziye, Hosseini, Arshad, Dokholyan, Nikolay V.

“…The binding of therapeutics to human serum albumin (HSA), which is an abundant protein in plasma poses a major challenge in drug discovery. Although HSA has…”
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Peptidomimetics in cancer targeting by Gomari, Mohammad Mahmoudi, Abkhiz, Shadi, Pour, Taha Ghantab, Lotfi, Ehsan, Rostami, Neda, Monfared, Fatemeh Nafe, Ghobari, Babak, Mosavi, Mona, Alipour, Behruz, Dokholyan, Nikolay V

“…The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been…”
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Design, Synthesis, and Comparison of PLA-PEG-PLA and PEG-PLA-PEG Copolymers for Curcumin Delivery to Cancer Cells by Rostami, Neda, Faridghiasi, Farzaneh, Ghebleh, Aida, Noei, Hadi, Samadzadeh, Meisam, Gomari, Mohammad Mahmoudi, Tajiki, Alireza, Abdouss, Majid, Aminoroaya, Alireza, Kumari, Manisha, Heidari, Reza, Uversky, Vladimir N, Smith, Bryan R

“…Curcumin (CUR) has potent anticancer activities, and its bioformulations, including biodegradable polymers, are increasingly able to improve CUR's solubility,…”
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Implementation of docking, molecular dynamics and free energy to investigate drug potency of novel BCR-ABLT315I inhibitors as an alternative to ponatinib by Mahmoudi Gomari, Mohammad, Rostami, Neda, Ghodrati, Atefe, Hernandez, Yaeren, Fadaie, Mahmood, Sadegh Eslami, Seyed, Tarighi, Parastoo

“…•Among three candidate drugs, JNJ-26854165 gained a higher score but was not as potent as ponatinib.•Ponatinib had more potency and affinity to interact with…”
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Designing a chimeric subunit vaccine for influenza virus, based on HA2, M2e and CTxB: a bioinformatics study by Jafari, Davod, Malih, Sara, Gomari, Mohammad Mahmoudi, Safari, Marzieh, Jafari, Rasool, Farajollahi, Mohammad Morad

“…Abstract Background Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due…”
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Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing by Rostami, Neda, Gomari, Mohammad Mahmoudi, Choupani, Edris, Abkhiz, Shadi, Fadaie, Mahmood, Eslami, Seyed Sadegh, Mahmoudi, Zahra, Zhang, Yapei, Puri, Madhu, Monfared, Fatemeh Nafe, Demireva, Elena, Uversky, Vladimir N., Smith, Bryan Ronain, Bencherif, Sidi A.

“…The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct…”
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Structure Evaluation of IroN for Designing a Vaccine against Escherichia Coli, an In Silico Approach by Sefid, Fateme, Baghban, Roghayyeh, Payandeh, Zahra, Khalesi, Bahman, Mahmoudi Gomari, Mohammad

“…Introduction: Some strains of Escherichia Coli, including intestinal pathogenic strains, commensal strains, and extra intestinal pathogenic E. coli (ExPEC)…”
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CD44 polymorphisms and its variants, as an inconsistent marker in cancer investigations by Gomari, Mohammad Mahmoudi, Farsimadan, Marziye, Rostami, Neda, mahmoudi, Zahra, Fadaie, Mahmood, Farhani, Ibrahim, Tarighi, Parastoo

“…Among cell surface markers, CD44 is considered the main marker for identifying and isolating the cancer stem cells (CSCs) among other cells and has attracted…”
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Structural evolution of Delta lineage of SARS-CoV-2 by Gomari, Mohammad Mahmoudi, Tarighi, Parastoo, Choupani, Edris, Abkhiz, Shadi, Mohamadzadeh, Masoud, Rostami, Neda, Sadroddiny, Esmaeil, Baammi, Soukayna, Uversky, Vladimir N., Dokholyan, Nikolay V.

“…One of the main obstacles in prevention and treatment of COVID-19 is the rapid evolution of the SARS-CoV-2 Spike protein. Given that Spike is the main target…”
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Peptide-functionalized polymeric nanoparticles for delivery of curcumin to cancer cells by Rostami, Neda, Ghebleh, Aida, Noei, Hadi, Rizi, Zahra Salimian, Moeinzadeh, Alaa, Nikzad, Abuzar, Gomari, Mohammad Mahmoudi, Uversky, Vladimir N., Tarighi, Parastoo

“…Polymeric nanoparticles (NPs) have garnered significant interest due to their potential in drug delivery. Specifically, nanopolymers functionalized with…”
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siRNA nanotherapeutics: a promising strategy for anti-HBV therapy by Aghamiri, Shahin, Jafarpour, Ali, Gomari, Mohammad Mahmoudi, Ghorbani, Jaber, Rajabibazl, Masoumeh, Payandeh, Zahra

“…Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC) and liver cirrhosis worldwide. In spite of the numerous advances in the…”
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Synthesis and Characterization of Folic Acid-Functionalized DPLA-co-PEG Nanomicelles for the Targeted Delivery of Letrozole by Rostami, Neda, Gomari, Mohammad Mahmoudi, Abdouss, Majid, Moeinzadeh, Alaa, Choupani, Edris, Davarnejad, Reza, Heidari, Reza, Bencherif, Sidi A.

“…An effective treatment for hormone-dependent breast cancer is chemotherapy using cytotoxic agents such as letrozole (LTZ). However, most anticancer drugs,…”
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Moderately hyperglycemia as an independent prognostic factor for the worse outcome of COVID-19 by Nateghi, Saeed, Gomari, Mohammad Mahmoudi, roudsari, Yousef Jalali, Foroughi, Alireza, Mansouri, Fariba, Shiva, Ashkan, Nasrollahizadeh, Ali, Nasiri, Zohreh, Faraji, Neda

“…Blood sugar (BS) has been proposed as a prognostic factor for COVID-19. In this historical cohort study we evaluated the association between admission time BS…”
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