Search Results - "Golubovskaya, Vita M."

Focal adhesion kinase as a cancer therapy target by Golubovskaya, Vita M

“…Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene…”
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FAK and Nanog cross talk with p53 in cancer stem cells by Golubovskaya, Vita M

“…This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in…”
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A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth by Golubovskaya, Vita M, Nyberg, Carl, Zheng, Min, Kweh, Frederick, Magis, Andrew, Ostrov, David, Cance, William G

“…Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors. We developed a novel cancer-therapy approach, targeting the…”
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Focal adhesion kinase and p53 signal transduction pathways in cancer by Golubovskaya, Vita M, Cance, William

“…Human cancer is characterized by a process of tumor cell motility, invasion, and metastasis. One of the critical tyrosine kinases that is linked to these…”
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Defective apical extrusion signaling contributes to aggressive tumor hallmarks by Gu, Yapeng, Shea, Jill, Slattum, Gloria, Firpo, Matthew A, Alexander, Margaret, Mulvihill, Sean J, Golubovskaya, Vita M, Rosenblatt, Jody

“…When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which…”
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Focal adhesion kinase versus p53: apoptosis or survival? by Cance, William G, Golubovskaya, Vita M

“…Focal adhesion kinase (FAK) is a tyrosine kinase that interacts with a multitude of signaling partners and helps cells to survive in the face of various…”
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FAK and p53 protein interactions by Golubovskaya, Vita M, Cance, William G

“…Focal Adhesion Kinase plays a major role in cell adhesion, motility, survival, proliferation, metastasis, angiogenesis and lymphangiogenesis. In 2004, we have…”
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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer by Hochwald, Steven N., Nyberg, Carl, Zheng, Min, Zheng, Donghang, Wood, Cheng, Massoll, Nicole A., Magis, Andrew, Ostrov, David, Cance, William G., Golubovskaya, Vita M.

“…Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is overexpressed in many types of tumors, including pancreatic cancer, and plays an important…”
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MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells by Golubovskaya, Vita M, Sumbler, Brittany, Ho, Baotran, Yemma, Michael, Cance, William G

“…Focal Adhesion Kinase is a 125 kDa non-receptor kinase and overexpressed in many types of tumors. Recently, short noncoding RNAs, called microRNAs have been…”
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Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy by Heffler, Melissa, Golubovskaya, Vita M, Dunn, Kelli M Bullard, Cance, William

“…Focal adhesion kinase (FAK) increasingly has been implicated in cancer growth and progression. 1,2,4,5-Benzenetetraamine tetrahydrochloride (Y15) is a small…”
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Evolving therapies and FAK inhibitors for the treatment of cancer by Dunn, Kelli Bullard, Heffler, Melissa, Golubovskaya, Vita M

“…Despite advances in medical and surgical therapy, cancer kills more than half a million people in the United States annually, and the majority of these…”
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Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53 by Golubovskaya, Vita M., Finch, Richard, Cance, William G.

“…Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors and associates with multiple cell surface receptors and…”
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FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes by Heffler, Melissa, Golubovskaya, Vita M, Conroy, Jeffrey, Liu, Song, Wang, Dan, Cance, William G, Dunn, Kelli B

“…Focal adhesion kinase (FAK), hyaluronan (HA), and hyaluronan synthase-3 (HAS3) have been implicated in cancer growth and progression. FAK inhibition with the…”
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FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells by Liu, Weiguo, Bloom, David A., Cance, William G., Kurenova, Elena V., Golubovskaya, Vita M., Hochwald, Steven N.

“…Pancreatic cancer is a lethal disease accounting for the fourth leading cause of cancer death in USA. Focal adhesion kinase (FAK) and the insulin-like growth…”
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Targeting FAK in human cancer: from finding to first clinical trials by Golubovskaya, Vita M

“…It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in many types of human cancer. FAK plays an important role in adhesion,…”
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Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells by Ho, Baotran, Huang, Grace, Golubovskaya, Vita M

“…Focal Adhesion Kinase (FAK) plays an important role in cancer cell survival. Previous microarray gene profiling study detected inverse regulation between…”
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A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo by Golubovskaya, Vita M, Palma, Nadia L, Zheng, Min, Ho, Baotran, Magis, Andrew, Ostrov, David, Cance, William G

“…Focal Adhesion Kinase (FAK) is overexpressed in many types of tumors and plays an important role in survival. We developed a novel approach, targeting…”
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Targeting the p53 Pathway by Golubovskaya, Vita M., PhD, Cance, William G., MD

“…This article summarizes data on translational studies to target the p53 pathway in cancer. It describes the functions of the p53 and Mdm-2 signaling pathways,…”
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Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma by Beierle, Elizabeth A., Ma, Xiaojie, Stewart, Jerry, Nyberg, Carl, Trujillo, Angelica, Cance, William G., Golubovskaya, Vita M.

“…Neuroblastoma is the most common extracranial solid tumor of childhood. Focal adhesion kinase (FAK) is an intracellular kinase that regulates both cellular…”
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FAK overexpression and p53 mutations are highly correlated in human breast cancer by Golubovskaya, Vita M., Conway‐Dorsey, Kathleen, Edmiston, Sharon N., Tse, Chiu‐Kit, Lark, Amy A., Livasy, Chad A., Moore, Dominic, Millikan, Robert C., Cance, William G.

“…Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor…”
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