Search Results - "Golub, Todd R"

Genomic evolution of cancer models: perils and opportunities by Ben-David, Uri, Beroukhim, Rameen, Golub, Todd R.

“…Cancer research relies on model systems, which reflect the biology of actual human tumours to only a certain extent. One important feature of human cancer is…”
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Copper induces cell death by targeting lipoylated TCA cycle proteins by Tsvetkov, Peter, Coy, Shannon, Petrova, Boryana, Dreishpoon, Margaret, Verma, Ana, Abdusamad, Mai, Rossen, Jordan, Joesch-Cohen, Lena, Humeidi, Ranad, Spangler, Ryan D, Eaton, John K, Frenkel, Evgeni, Kocak, Mustafa, Corsello, Steven M, Lutsenko, Svetlana, Kanarek, Naama, Santagata, Sandro, Golub, Todd R

“…Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved…”
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A metastasis map of human cancer cell lines by Jin, Xin, Demere, Zelalem, Nair, Karthik, Ali, Ahmed, Ferraro, Gino B., Natoli, Ted, Deik, Amy, Petronio, Lia, Tang, Andrew A., Zhu, Cong, Wang, Li, Rosenberg, Danny, Mangena, Vamsi, Roth, Jennifer, Chung, Kwanghun, Jain, Rakesh K., Clish, Clary B., Vander Heiden, Matthew G., Golub, Todd R.

“…Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical owing to the complexity of in vivo models…”
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The Drug Repurposing Hub: a next-generation drug library and information resource by Corsello, Steven M, Bittker, Joshua A, Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E, Johnston, Stephen E, Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C, Subramanian, Aravind, Golub, Todd R

“…Drug repurposing, the application of an existing therapeutic to a new disease indication, holds promise of rapid clinical impact at a lower cost than de novo…”
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Genetic and transcriptional evolution alters cancer cell line drug response by Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.

“…Human cancer cell lines are the workhorse of cancer research. Although cell lines are known to evolve in culture, the extent of the resultant genetic and…”
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Cas9 activates the p53 pathway and selects for p53-inactivating mutations by Enache, Oana M., Rendo, Veronica, Abdusamad, Mai, Lam, Daniel, Davison, Desiree, Pal, Sangita, Currimjee, Naomi, Hess, Julian, Pantel, Sasha, Nag, Anwesha, Thorner, Aaron R., Doench, John G., Vazquez, Francisca, Beroukhim, Rameen, Golub, Todd R., Ben-David, Uri

“…Cas9 is commonly introduced into cell lines to enable CRISPR–Cas9-mediated genome editing. Here, we studied the genetic and transcriptional consequences of…”
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Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells by Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad

“…CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and…”
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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration by McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

“…The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for…”
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The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research by Painter, Corrie A., Jain, Esha, Tomson, Brett N., Dunphy, Michael, Stoddard, Rachel E., Thomas, Beena S., Damon, Alyssa L., Shah, Shahrayz, Kim, Dewey, Gómez Tejeda Zañudo, Jorge, Hornick, Jason L., Chen, Yen-Lin, Merriam, Priscilla, Raut, Chandrajit P., Demetri, George D., Van Tine, Brian A., Lander, Eric S., Golub, Todd R., Wagle, Nikhil

“…Despite rare cancers accounting for 25% of adult tumors 1 , they are difficult to study due to the low disease incidence and geographically dispersed patient…”
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Protection of tissue physicochemical properties using polyfunctional crosslinkers by Park, Young-Gyun, Sohn, Chang Ho, Chen, Ritchie, McCue, Margaret, Yun, Dae Hee, Drummond, Gabrielle T, Ku, Taeyun, Evans, Nicholas B, Oak, Hayeon Caitlyn, Trieu, Wendy, Choi, Heejin, Jin, Xin, Lilascharoen, Varoth, Wang, Ji, Truttmann, Matthias C, Qi, Helena W, Ploegh, Hidde L, Golub, Todd R, Chen, Shih-Chi, Frosch, Matthew P, Kulik, Heather J, Lim, Byung Kook, Chung, Kwanghun

“…Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture. Understanding complex…”
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Comprehensive assessment of cancer missense mutation clustering in protein structures by Kamburov, Atanas, Lawrence, Michael S., Polak, Paz, Leshchiner, Ignaty, Lage, Kasper, Golub, Todd R., Lander, Eric S., Getz, Gad

“…Large-scale tumor sequencing projects enabled the identification of many new cancer gene candidates through computational approaches. Here, we describe a…”
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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer by Polak, Paz, Kim, Jaegil, Braunstein, Lior Z, Karlic, Rosa, Haradhavala, Nicholas J, Tiao, Grace, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W, Kamburov, Atanas, Maruvka, Yosef E, Leshchiner, Ignaty, Lander, Eric S, Golub, Todd R, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S, Batra, Rajbir N, Caldas, Carlos, Haber, Daniel A, Laird, Peter W, Shen, Hui, Ellisen, Leif W, D'Andrea, Alan D, Chanock, Stephen J, Foulkes, William D, Getz, Gad

“…Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to…”
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Impaired microRNA processing enhances cellular transformation and tumorigenesis by Jacks, Tyler, Kumar, Madhu S, Lu, Jun, Mercer, Kim L, Golub, Todd R

“…MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate the expression of target mRNA transcripts. Many of these target…”
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Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma by Green, Michael R., Monti, Stefano, Rodig, Scott J., Juszczynski, Przemyslaw, Currie, Treeve, O'Donnell, Evan, Chapuy, Bjoern, Takeyama, Kunihiko, Neuberg, Donna, Golub, Todd R., Kutok, Jeffery L., Shipp, Margaret A.

“…Classical Hodgkin lymphoma (cHL) and mediastinal large B-cell lymphoma (MLBCL) are lymphoid malignancies with certain shared clinical, histologic, and…”
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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map by Smith, Ian, Greenside, Peyton G, Natoli, Ted, Lahr, David L, Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E, Golub, Todd R, Subramanian, Aravind, Doench, John G

“…The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes…”
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Recurrent and functional regulatory mutations in breast cancer by Rheinbay, Esther, Parasuraman, Prasanna, Grimsby, Jonna, Tiao, Grace, Engreitz, Jesse M., Kim, Jaegil, Lawrence, Michael S., Taylor-Weiner, Amaro, Rodriguez-Cuevas, Sergio, Rosenberg, Mara, Hess, Julian, Stewart, Chip, Maruvka, Yosef E., Stojanov, Petar, Cortes, Maria L., Seepo, Sara, Cibulskis, Carrie, Tracy, Adam, Pugh, Trevor J., Lee, Jesse, Zheng, Zongli, Ellisen, Leif W., Iafrate, A. John, Boehm, Jesse S., Gabriel, Stacey B., Meyerson, Matthew, Golub, Todd R., Baselga, Jose, Hidalgo-Miranda, Alfredo, Shioda, Toshi, Bernards, Andre, Lander, Eric S., Getz, Gad

“…Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By…”
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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets by Dempster, Joshua M., Pacini, Clare, Pantel, Sasha, Behan, Fiona M., Green, Thomas, Krill-Burger, John, Beaver, Charlotte M., Younger, Scott T., Zhivich, Victor, Najgebauer, Hanna, Allen, Felicity, Gonçalves, Emanuel, Shepherd, Rebecca, Doench, John G., Yusa, Kosuke, Vazquez, Francisca, Parts, Leopold, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco

“…Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a systematic approach to identify cancer dependencies and new therapeutic…”
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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis by Rampal, Raajit, Al-Shahrour, Fatima, Abdel-Wahab, Omar, Patel, Jay P., Brunel, Jean-Philippe, Mermel, Craig H., Bass, Adam J., Pretz, Jennifer, Ahn, Jihae, Hricik, Todd, Kilpivaara, Outi, Wadleigh, Martha, Busque, Lambert, Gilliland, D. Gary, Golub, Todd R., Ebert, Benjamin L., Levine, Ross L.

“…Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of…”
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An ecosystem of cancer cell line factories to support a cancer dependency map by Boehm, Jesse S., Golub, Todd R.

“…Jesse Boehm and Todd Golub call for an international effort to establish >10,000 cancer cell line models as a community resource. Cancer cell line factories…”
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS by Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

“…ROS-mediated anticancer compound A chemical screen has identified a small molecule, piperlongumine (PL), as a compound that induces selective killing of cancer…”
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