Search Results - "Golub, T. R."

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring by Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., Bloomfield, C. D., Lander, E. S.

“…Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or…”
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Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures by Ramaswamy, Sridhar, Tamayo, Pablo, Rifkin, Ryan, Mukherjee, Sayan, Yeang, Chen-Hsiang, Angelo, Michael, Ladd, Christine, Reich, Michael, Latulippe, Eva, Mesirov, Jill P., Poggio, Tomaso, Gerald, William, Loda, Massimo, Lander, Eric S., Golub, Todd R.

“…The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data…”
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Genomic analysis of metastasis reveals an essential role for RhoC by Clark, Edwin A, Golub, Todd R, Lander, Eric S, Hynes, Richard O

“…The most damaging change during cancer progression is the switch from a locally growing tumour to a metastatic killer. This switch is believed to involve…”
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Genome-Wide Views of Cancer by Golub, Todd R

“…Nearly coincident with the publication of the article by Hedenfalk et al. 1 in this issue of the Journal are reports of the complete DNA sequence of the human…”
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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation by Golub, T R, Barker, G F, Lovett, M, Gilliland, D G

“…Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome characterized by abnormal clonal myeloid proliferation and by progression to acute…”
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Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas by Takeyama, K, Monti, S, Manis, J P, Cin, P Dal, Getz, G, Beroukhim, R, Dutt, S, Aster, J C, Alt, F W, Golub, T R, Shipp, M A

“…p53-Binding protein 1 ( 53BP1 ) encodes a critical checkpoint protein that localizes to sites of DNA double-strand breaks (DSBs) and participates in DSB…”
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Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030 by Parsons, H.A., Blewett, T., Chu, X., Sridhar, S., Santos, K., Xiong, K., Abramson, V.G., Patel, A., Cheng, J., Brufsky, A., Rhoades, J., Force, J., Liu, R., Traina, T.A., Carey, L.A., Rimawi, M.F., Miller, K.D., Stearns, V., Specht, J., Falkson, C., Burstein, H.J., Wolff, A.C., Winer, E.P., Tayob, N., Krop, I.E., Makrigiorgos, G.M., Golub, T.R., Mayer, E.L., Adalsteinsson, V.A.

“…We aimed to examine circulating tumor DNA (ctDNA) and its association with residual cancer burden (RCB) using an ultrasensitive assay in patients with…”
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Fusion of the TEL Gene on 12p13 to the AML1 Gene on 21q22 in Acute Lymphoblastic Leukemia by Golub, Todd R., Barker, George F., Bohlander, Stefan K., Hiebert, Scott W., Ward, David C., Bray-Ward, Patricia, Morgan, Elaine, Raimondi, Susana C., Rowley, Janet D., Gilliland, D. Gary

“…Chromosomal rearrangements involving band 12p13 are found in a wide variety of human leukemias but are particularly common in childhood acute lymphoblastic…”
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PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling by Shrestha, Y, Schafer, E J, Boehm, J S, Thomas, S R, He, F, Du, J, Wang, S, Barretina, J, Weir, B A, Zhao, J J, Polyak, K, Golub, T R, Beroukhim, R, Hahn, W C

“…Activating mutations in the RAS family or BRAF frequently occur in many types of human cancers but are rarely detected in breast tumors. However, activation of…”
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TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia by MCLEAN, T. W, RINGOLD, S, BARTRAM, C. R, SALLAN, S. E, GILLILAND, D. G, GOLUB, T. R, NEUBERG, D, STEGMAIER, K, TANTRAVAHI, R, RITZ, J, KOEFFLER, H. P, TAKEUCHI, S, JANSSEN, J. W. G, SERIU, T

“…Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML1 fusion transcript was detected in 27%…”
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Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia by Golub, Todd R., Goga, Andrei, Barker, George F., Afar, Daniel E. H., McLaughlin, Jami, Bohlander, Stefan K., Rowley, Janet D., Witte, Owen N., Gilliland, D. Gary

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A molecular signature of metastasis in primary solid tumors by Ramaswamy, Sridhar, Golub, Todd R, Ross, Ken N, Lander, Eric S

“…Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To explore the molecular…”
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p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines by Okuda, K, Golub, T R, Gilliland, D G, Griffin, J D

“…The Philadelphia chromosome translocation generates a chimeric oncogene, BCR/ABL which causes chronic myelogenous leukemia. Two different fusion proteins can…”
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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis by Levine, Ross L., Wadleigh, Martha, Cools, Jan, Ebert, Benjamin L., Wernig, Gerlinde, Huntly, Brian J.P., Boggon, Titus J., Wlodarska, Iwona, Clark, Jennifer J., Moore, Sandra, Adelsperger, Jennifer, Koo, Sumin, Lee, Jeffrey C., Gabriel, Stacey, Mercher, Thomas, D’Andrea, Alan, Fröhling, Stefan, Döhner, Konstanze, Marynen, Peter, Vandenberghe, Peter, Mesa, Ruben A., Tefferi, Ayalew, Griffin, James D., Eck, Michael J., Sellers, William R., Meyerson, Matthew, Golub, Todd R., Lee, Stephanie J., Gilliland, D. Gary

“…Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic…”
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TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies by SATO, Y, SUTO, Y, BOHLANDER, S. K, PIETENPOL, J, GOLUB, T. R, GILLILAND, D. G, DAVIS, E. M, LE BEAU, M. M, ROBERTS, J. M, VOGELSTEIN, B, ROWLEY, J. D

“…Unbalanced translocations as well as interstitial deletions of the short arm of chromosome 12 [del(12p)] are found as recurring chromosomal changes in a broad…”
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Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation by BEDELL, M. A, HUDSON, J. B, GOLUB, T. R, TURYK, M. E, HOSKEN, M, WILBANKS, G. D, LAIMINS, L. A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia by TAKEUCHI, S, SERIU, T, BARTRAM, C. R, GOLUB, T. R, REITER, A, MIYOSHI, I, GILLILAND, D. G, KOEFFLER, H. P

“…Abnormalities of the short arm of chromosome 12 including loss of heterozygosity (LOH) and TEL/AML-1 fusion resulting from a t(12;21)(p13;q22) translocation…”
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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia by Golub, Todd R, Korsmeyer, Stanley J, Armstrong, Scott A, Staunton, Jane E, Silverman, Lewis B, Pieters, Rob, den Boer, Monique L, Minden, Mark D, Sallan, Stephen E, Lander, Eric S

“…Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor…”
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Gene expression correlates of clinical prostate cancer behavior by Singh, Dinesh, Febbo, Phillip G., Ross, Kenneth, Jackson, Donald G., Manola, Judith, Ladd, Christine, Tamayo, Pablo, Renshaw, Andrew A., D'Amico, Anthony V., Richie, Jerome P., Lander, Eric S., Loda, Massimo, Kantoff, Philip W., Golub, Todd R., Sellers, William R.

“…Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether…”
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Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF by Du, Jinyan, Widlund, Hans R., Horstmann, Martin A., Ramaswamy, Sridhar, Ross, Ken, Huber, Wade E., Nishimura, Emi K., Golub, Todd R., Fisher, David E.

“…The genomic organization of the CDK2 gene, which overlaps the melanocyte-specific gene SILV/PMEL17, poses an interesting regulatory challenge. We show that,…”
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