Search Results - "Golub, L.M."

Can Systemic Diseases Co-induce (Not Just Exacerbate) Periodontitis? A Hypothetical “Two-hit” Model by Golub, L.M., Payne, J.B., Reinhardt, R.A., Nieman, G.

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Doxycycline Effects on Serum Bone Biomarkers in Post-menopausal Women by Golub, L.M., Lee, H.-M., Stoner, J.A., Reinhardt, R.A., Sorsa, T., Goren, A.D., Payne, J.B.

“…We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease…”
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Serum Bone Biomarkers and Oral/Systemic Bone Loss in Humans by Payne, J.B., Stoner, J.A., Lee, H.-M., Nummikoski, P.V., Reinhardt, R.A., Golub, L.M.

“…We recently reported that subantimicrobial-dose doxycycline (SDD) significantly reduced serum bone-resorption biomarkers in subgroups of post-menopausal women…”
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Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms by Golub, L M, Lee, H M, Ryan, M E, Giannobile, W V, Payne, J, Sorsa, T

“…A seminal experiment involving a germ-free rat model of connective tissue breakdown (followed soon thereafter by a series of in vitro studies) identified an…”
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Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells by Hanemaaijer, R, Visser, H, Koolwijk, P, Sorsa, T, Salo, T, Golub, L M, van Hinsbergh, V W

“…Doxycycline is a commonly used broad-spectrum antibiotic. Recently, it has been shown that it also inhibits the activity of mammalian collagenases and…”
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The "cyclic" regimen of low-dose doxycycline for adult periodontitis: a preliminary study by Crout, R J, Lee, H M, Schroeder, K, Crout, H, Ramamurthy, N S, Wiener, M, Golub, L M

“…Specially-formulated low-dose doxycycline (LDD) regimens have been found to reduce collagenase activity in the gingival tissues and crevicular fluid (GCF) of…”
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Loss of alveolar bone density in post-menopausal, osteopenic women is associated with circulating levels of gelatinases by THOMPSON, D.M., LEE, H.M., STONER, J.A., GOLUB, L.M., NUMMIKOSKI, P.V., PAYNE, J.B.

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A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity by Golub, L M, McNamara, T F, D'Angelo, G, Greenwald, R A, Ramamurthy, N S

“…Tetracyclines (including the semi-synthetic analogues, minocycline and doxycycline) are considered useful adjuncts in periodontal therapy because they suppress…”
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Periodontopathic potential of two strains of Porphyromonas gingivalis in gnotobiotic rats by Evans, R T, Klausen, B, Ramamurthy, N S, Golub, L M, Sfintescu, C, Genco, R J

“…Germ-free rats were monoinfected with Porphyromonas gingivalis strains 381 or A7A1-28 for 42 or 84 days. Both strains induced substantial destruction of…”
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In Vitro Sensitivity of the Three Mammalian Collagenases to Tetracycline Inhibition: Relationship to Bone and Cartilage Degradation by Greenwald, R.A, Golub, L.M, Ramamurthy, N.S, Chowdhury, M, Moak, S.A, Sorsa, T

“…There are at least nine tetracycline (TC) analogs (both antimicrobial and nonantimicrobial) with documented capacity to inhibit, both in vitro and in vivo, the…”
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Inhibition of Proteolytic, Serpinolytic, and Progelatinase‐B Activation Activities of Periodontopathogens by Doxycycline and the Non‐Antimicrobial Chemically Modified Tetracycline Derivatives by Grenier, D., Plamondon, P., Sorsa, T., Lee, H‐M., McNamara, T., Ramamurthy, N.S, Golub, L.M., Teronen, O., Mayrand, D.

“…Background: Tetracyclines, particularly doxycycline (Doxy), and their nonantimicrobial chemically‐modified derivatives (CMTs) inhibit the activities of human…”
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Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats by Bain, S., Ramamurthy, N.S., Impeduglia, T., Scolman, S., Golub, L.M., Rubin, C.

“…The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in…”
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Tetracyclines inhibit protein glycation in experimental diabetes by Ryan, M E, Ramamurthy, N S, Golub, L M

“…Glycation of proteins, which is accelerated in the diabetic state, has been implicated in many of the long-term complications of diabetes. This process can be…”
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Long-term therapy with a new chemically modified tetracycline (CMT-8) inhibits bone loss in femurs of ovariectomized rats by Sasaki, T, Ramamurthy, N S, Golub, L M

“…The effect of a new non-antimicrobial analog of tetracycline (CMT-8) on bone loss in ovariectomized (OVX) rats was examined. Three-month-old female rats were…”
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Tetracycline/flurbiprofen combination therapy modulates bone remodeling in ovariectomized rats: Preliminary observations by Aoyagi, M., Sasaki, T., Ramamurthy, N.S., Golub, L.M.

“…The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two…”
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Potential application of a chemically modified non-antimicrobial tetracycline (CMT-3) against metastatic prostate cancer by Lokeshwar, B L, Houston-Clark, H L, Selzer, M G, Block, N L, Golub, L M

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Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin by Ramamurthy, N S, Kucine, A J, McClain, S A, McNamara, T F, Golub, L M

“…Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current…”
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Bone cells and matrix bind chemically modified non-antimicrobial tetracycline by Sasaki, T, Ramamurthy, N S, Golub, L M

“…3H-labeled chemically modified, non-antimicrobial tetracycline (4-de-dimethyl-aminotetracycline; CMT) was injected intraperitoneally into neonatal rats and the…”
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Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines by Ramamurthy, N S, Schroeder, K L, McNamara, T F, Gwinnett, A J, Evans, R T, Bosko, C, Golub, L M

“…The incidence of root caries has been found to increase as the population ages and as edentulism becomes less prevalent due to improved dental awareness and…”
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Extensive degradation of recently synthesized collagen in gingiva of normal and streptozotocin-induced diabetic rats by Schneir, M L, Ramamurthy, N S, Golub, L M

“…The degradation of recently synthesized collagen (probably procollagen) in rat incisor gingiva was three times greater than that in skin. Concomitantly, the…”
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