Search Results - "Golson, Maria L."

Fox transcription factors: from development to disease by Golson, Maria L, Kaestner, Klaus H

“…Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes…”
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Single-Cell Transcriptomics of the Human Endocrine Pancreas by Wang, Yue J, Schug, Jonathan, Won, Kyoung-Jae, Liu, Chengyang, Naji, Ali, Avrahami, Dana, Golson, Maria L, Kaestner, Klaus H

“…Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of rare cellular states and uncover population heterogeneity, we…”
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Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas by Wang, Yue J., Golson, Maria L., Schug, Jonathan, Traum, Daniel, Liu, Chengyang, Vivek, Kumar, Dorrell, Craig, Naji, Ali, Powers, Alvin C., Chang, Kyong-Mi, Grompe, Markus, Kaestner, Klaus H.

“…The human endocrine pancreas consists of multiple cell types and plays a critical role in glucose homeostasis. Here, we apply mass cytometry technology…”
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α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals by Doliba, Nicolai M, Rozo, Andrea V, Roman, Jeffrey, Qin, Wei, Traum, Daniel, Gao, Long, Liu, Jinping, Manduchi, Elisabetta, Liu, Chengyang, Golson, Maria L, Vahedi, Golnaz, Naji, Ali, Matschinsky, Franz M, Atkinson, Mark A, Powers, Alvin C, Brissova, Marcela, Kaestner, Klaus H, Stoffers, Doris A

“…BACKGROUNDMultiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in…”
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Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche by Aoki, Reina, Shoshkes-Carmel, Michal, Gao, Nan, Shin, Soona, May, Catherine L, Golson, Maria L, Zahm, Adam M, Ray, Michael, Wiser, Caroline L, Wright, Christopher V.E, Kaestner, Klaus H

“…Background & Aims Intestinal epithelial stem cells that express leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) and/or B cell specific…”
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Epigenetics in formation, function, and failure of the endocrine pancreas by Golson, Maria L, Kaestner, Klaus H

“…Abstract Background Epigenetics, in the broadest sense, governs all aspects of the life of any multicellular organism, as it controls how differentiated cells…”
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The leptin receptor has no role in delta-cell control of beta-cell function in the mouse by Zhang, Jia, Katada, Kay, Mosleh, Elham, Yuhas, Andrew, Peng, Guihong, Golson, Maria L

“…Leptin inhibits insulin secretion from isolated islets from multiple species, but the cell type that mediates this process remains elusive. Several mouse…”
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Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation by Mosleh, Elham, Ou, Kristy, Haemmerle, Matthew W, Tembo, Teguru, Yuhas, Andrew, Carboneau, Bethany A, Townsend, Shannon E, Bosma, Karin J, Gannon, Maureen, O’Brien, Richard M, Stoffers, Doris A, Golson, Maria L

“…Abstract Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly…”
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Ductal Malformation and Pancreatitis in Mice Caused by Conditional Jag1 Deletion by Golson, Maria L, Loomes, Kathleen M, Oakey, Rebecca, Kaestner, Klaus H

“…Background & Aims Alagille syndrome is an autosomal dominant disorder caused by mutations in Notch signaling pathway genes, usually JAGGED1 . Up to 40% of…”
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Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity by Rabbani, Zahid N, Anscher, Mitchell S, Folz, Rodney J, Archer, Emerald, Huang, Hong, Chen, Liguang, Golson, Maria L, Samulski, Thaddeus S, Dewhirst, Mark W, Vujaskovic, Zeljko

“…Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury…”
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Pancreatic δ Cells: An Overlooked Cell in Focus by Golson, Maria L

“…Pancreatic δ cells act locally to repress both insulin and glucagon secretion. Because they are a rare cell type, experimentation examining δ-cell function and…”
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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk by Su, Chun, Gao, Long, May, Catherine L, Pippin, James A, Boehm, Keith, Lee, Michelle, Liu, Chengyang, Pahl, Matthew C, Golson, Maria L, Naji, Ali, Grant, Struan F A, Wells, Andrew D, Kaestner, Klaus H

“…Three-dimensional (3D) chromatin organization maps help dissect cell-type-specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to…”
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A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells by Zelent, Dorothy, Golson, Maria L, Koeberlein, Brigitte, Quintens, Roel, van Lommel, Leentje, Buettger, Carol, Weik-Collins, Heather, Taub, Rebecca, Grimsby, Joseph, Schuit, Frans, Kaestner, Klaus H, Matschinsky, Franz M

“…A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells Dorothy Zelent 1 , Maria L. Golson 1 , Brigitte Koeberlein 1 , Roel Quintens 2 , Leentje van…”
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Epigenetic control of β-cell function and failure by Bernstein, Diana, Golson, Maria L, Kaestner, Klaus H

“…Summary Type 2 Diabetes is a highly heritable disease, but only ∼15% of this heritability can be explained by known genetic variant loci. In fact, body mass…”
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The Dysregulation of the DLK1 - MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs by Kameswaran, Vasumathi, Golson, Maria L, Ramos-Rodríguez, Mireia, Ou, Kristy, Wang, Yue J, Zhang, Jia, Pasquali, Lorenzo, Kaestner, Klaus H

“…Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing β-cells to overcome insulin resistance. We previously identified an…”
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Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies by Guo, Zheng, Kasinathan, Devi, Merriman, Chengfeng, Nakayama, Maki, Li, Hua, Li, Huilin, Xu, Cheng, Wong, G William, Yu, Liping, Golson, Maria L, Fu, Dax

“…Type 1 diabetes (T1D) is a disease in which autoimmune attacks are directed at the insulin-producing β-cell in the pancreatic islet. Autoantigens on the β-cell…”
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Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice by Kasinathan, Devi, Guo, Zheng, Sarver, Dylan C, Wong, G William, Yun, Shumei, Michels, Aaron W, Yu, Liping, Sona, Chandan, Poy, Matthew N, Golson, Maria L, Fu, Dax

“…Type 1 diabetes (T1D) is an autoimmune disease in which pathogenic lymphocytes target autoantigens expressed in pancreatic islets, leading to the destruction…”
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Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits by Lasconi, Chiara, Pahl, Matthew C, Pippin, James A, Su, Chun, Johnson, Matthew E, Chesi, Alessandra, Boehm, Keith, Manduchi, Elisabetta, Ou, Kristy, Golson, Maria L, Wells, Andrew D, Kaestner, Klaus H, Grant, Struan F A

“…Abstract We investigated the potential role of sleep-trait associated genetic loci in conferring a degree of their effect via pancreatic α- and β-cells, given…”
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Automated quantification of pancreatic β-cell mass by Golson, Maria L, Bush, William S, Brissova, Marcela

“…β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using…”
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Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes by Fasolino, Maria, Schwartz, Gregory W., Patil, Abhijeet R., Mongia, Aanchal, Golson, Maria L., Wang, Yue J., Morgan, Ashleigh, Liu, Chengyang, Schug, Jonathan, Liu, Jinping, Wu, Minghui, Traum, Daniel, Kondo, Ayano, May, Catherine L., Goldman, Naomi, Wang, Wenliang, Feldman, Michael, Moore, Jason H., Japp, Alberto S., Betts, Michael R., Faryabi, Robert B., Naji, Ali, Kaestner, Klaus H., Vahedi, Golnaz

“…Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy insulin-producing beta cells. The aetiology of this complex disease is dependent…”
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