Search Results - "Golovina, Elena S."

Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT6 Receptor (5-HT6R) Antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Kysil, Volodymyr M, Mitkin, Oleg D, Tkachenko, Sergey E, Okun, Ilya M

“…Syntheses, biological evaluation as 5-HT6 receptor (5-HT6R) antagonists, and structure–activity relationships for a series of novel 5,7-disubstituted…”
Get full text

(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT6 Receptor by Ivachtchenko, Alexandre V, Dmitriev, Dmitri E, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Kysil, Volodymyr M, Mitkin, Oleg D, Okun, Ilya M, Tkachenko, Sergey E, Vorobiev, Anton A

“…5-HT6 receptors are exclusively localized in the CNS and have high affinity with many psychotropic agents. Though the role of this receptor in many CNS…”
Get full text

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya

“…Syntheses of a series of novel 3-sulfonyl-pyrazolo[1,5-a]pyrimidines and their 5-HT6 receptor antagonistic structure–activity relationship are disclosed. The…”
Get full text

Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Vorobiev, Anton A., Okun, Ilya

“…Synthesis and biological evaluation of a new series of structurally unrestricted and intramolecular hydrogen bond restricted derivatives of…”
Get full text

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Mitkin, Oleg D, Tkachenko, Sergey E, Kysil, Volodymyr M, Okun, Ilya

“…Syntheses, biological evaluation, and structure-activity relationships for a series of novel 2-substituted…”
Get full text

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists by IVACHTCHENKO, Alexandre V, DMITRIEV, Dmitri E, VOROBIOV, Anton A, GOLOVINA, Elena S, DUBROVSKAYA, Elena S, KADIEVA, Madina G, KORYAKOVA, Angela G, KYSIL, Volodymyr M, MITKIN, Oleg D, TKACHENKO, Sergey E, OKUN, Ilya M

“…Synthesis and biological evaluation of 1 ('angular') and 2 ('linear') cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines as novel ligands of the…”
Get full text

Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kovalenko, Sergiy M., Mitkin, Oleg D., Okun, Ilya M., Ravnyeyko, Irina M., Tkachenko, Sergey E., Zaremba, Oleg V.

“…A number of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines were prepared and their 5-HT6 receptor binding affinity and ability to inhibit the…”
Get full text

Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5- a ]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT 6 Receptor (5-HT 6 R) Antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya M.

Get full text

Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: Selective Serotonin 5-HT6 Receptor Antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Kovalenko, Sergiy M, Mitkin, Oleg D, Okun, Ilya M, Ravnyeyko, Irina M, Tkachenko, Sergey E, Zaremba, Oleg V

“…Here we present the solution phase parallel synthesis of a combinatorial library consisting of 776 new substituted…”
Get full text

Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidinesaSynthes is and astructureaactivitya relationship by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Kysil, Volodymyr M, Mitkin, Oleg D, Vorobiev, Anton A, Okun, Ilya

“…Synthesis and biological evaluation of a new series of structurally unrestricted and intramolecular hydrogen bond restricted derivatives of…”
Get full text

Development and Validation of Approach for the Detection of Neutralizing Antibodies Against Insulin (Glargine) in Human Blood Plasma by Abramenko, N. A., Vnukova, P. I., Golovina, E. S., Makarenko, I. E., Mosikian, A. A., Nikiforova, A. G., Gremyakova, P. A., Kazey, V. I.

“…Introduction.  IImmunogenicity identification of therapeutic proteins, such as human insulin analogues, is one of the most relevant and significant area in…”
Get full text

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5- a]pyrimidines: New series of highly potent and specific serotonin 5-HT 6 receptor antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Mitkin, Oleg D., Tkachenko, Sergey E., Kysil, Volodymyr M., Okun, Ilya

“…Syntheses, biological evaluation, and structure–activity relationships for a series of novel 2-substituted 3-benzenesulfonyl-5,6-dimethyl-pyrazolo[1,5-…”
Get full text

(3-Phenylsulfonylcycloalkano[ e and d ]pyrazolo[1,5- a ]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT 6 Receptor by Ivachtchenko, Alexandre V., Dmitriev, Dmitri E., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kysil, Volodymyr M., Mitkin, Oleg D., Okun, Ilya M., Tkachenko, Sergey E., Vorobiev, Anton A.

Get full text

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT sub(6) receptor antagonists by Ivachtchenko, Alexandre V, Dmitriev, Dmitri E, Golovina, Elena S, Dubrovskaya, Elena S, Kadieva, Madina G, Koryakova, Angela G, Kysil, Volodymyr M, Mitkin, Oleg D, Tkachenko, Sergey E, Okun, Ilya M, Vorobiov, Anton A

“…Synthesis and biological evaluation of 1 ('angular') and 2 ('linear') cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines as novel ligands of the…”
Get full text

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5- a]pyrimidines and their evaluation as 5-HT 6 receptor antagonists by Ivachtchenko, Alexandre V., Dmitriev, Dmitri E., Golovina, Elena S., Dubrovskaya, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya M., Vorobiov, Anton A.

“…We synthesized and investigated the cycloalkane-annelated 3-phenyl-pyrazolo[1,5- a]pyrimidine systems, 1 and 2, as a novel scaffold for the development of…”
Get full text

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT sub(6 receptor antagonists) by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Kysil, Volodymyr M, Mitkin, Oleg D, Tkachenko, Sergey E, Okun, Ilya, Xaxzrpbfudlbqy-Uhfffaoysa-N, InChiKey: XGRULCORSXSJMU-UHFFFAOYSA-N, FHTHODOLGSGNKC-UHFFFAOYSA-N, WTCSFQDXLLFGFG-UHFFFAOYSA-N, CIJYPUVXZVJNIK-UHFFFAOYSA-N, CMMVQEMVPHMYAX-UHFFFAOYSA-N, KPHVCQHKHZETCF-UHFFFAOYSA-N, CJNJTBVSPDHDIH-UHFFFAOYSA-N, ZKKWRCSTEPFZDF-UHFFFAOYSA-N, NBASEYFJBAVLDK-UHFFFAOYSA-N, QOPOFWNBOBVJPE-UHFFFAOYSA-N, YAXQJPOZKDXPBY-UHFFFAOYSA-N, CWEKNSLCAWLROJ-UHFFFAOYSA-N, WNRRPUVNHOWZFD-UHFFFAOYSA-N, KDUSPNDDQIZEGT-UHFFFAOYSA-N, QSPVQFNITBFSRY-UHFFFAOYSA-N, CWHCBHFBRORBJX-UHFFFAOYSA-N, MDSIFERMIAZRAO-UHFFFAOYSA-N, XEKXWUDGXMEULY-UHFFFAOYSA-N, IAPLOUHCOKXYDI-UHFFFAOYSA-N, KVSJSNMBDMWWIA-UHFFFAOYSA-N, BQLYGLDNQZMPQV-UHFFFAOYSA-N, IUXYJICWWRCNRN-UHFFFAOYSA-N, DGZRDRVJWDVPCG-UHFFFAOYSA-N, LLRSKWJLJFTWMG-UHFFFAOYSA-N, MZLLXENSSNWXKW-UHFFFAOYSA-N, LYPYSDSVJRKEDT-UHFFFAOYSA-N, PVCZORLSESOJBZ-UHFFFAOYSA-N, BFOXZWKSDUOKPO-UHFFFAOYSA-N, DXULVPMDABIRHL-UHFFFAOYSA-N, WAWIENOYLSZDBE-UHFFFAOYSA-N, AKYBXIOZAWNEGP-UHFFFAOYSA-N, QKGIEOVAASUNSI-UHFFFAOYSA-N, YXXJGHIVBQTMRG-UHFFFAOYSA-N, WOZJSOBIIURLMO

“…Syntheses of a series of novel 3-sulfonyl-pyrazolo[1,5-a]pyrimidines and their 5-HT sub(6 receptor antagonistic structure-activity relationship are disclosed…”
Get full text

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists by IVACHTCHENKO, Alexandre V, GOLOVINA, Elena S, KADIEVA, Madina G, KYSIL, Volodymyr M, MITKIN, Oleg D, TKACHENKO, Sergey E, OKUN, Ilya

Get full text

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Kysil, Volodymyr M, Mitkin, Oleg D, Tkachenko, Sergey E, Okun, Ilya M

“…Syntheses, biological evaluation as 5-HT(6) receptor (5-HT(6)R) antagonists, and structure-activity relationships for a series of novel 5,7-disubstituted…”
Get full text

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New series of highly potent and specific serotonin 5-HT6 receptor antagonists by IVACHTCHENKO, Alexandre V, GOLOVINA, Elena S, KADIEVA, Madina G, KORYAKOVA, Angela G, MITKIN, Oleg D, TKACHENKO, Sergey E, KYSIL, Volodymyr M, OKUN, Ilya

Get full text

Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5- a ]quinazolines: Selective Serotonin 5-HT 6 Receptor Antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kovalenko, Sergiy M., Mitkin, Oleg D., Okun, Ilya M., Ravnyeyko, Irina M., Tkachenko, Sergey E., Zaremba, Oleg V.

Get full text