Search Results - "Gollob, Jared"

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial by Fitzgerald, Kevin, Dr, Frank-Kamenetsky, Maria, PhD, Shulga-Morskaya, Svetlana, MSc, Liebow, Abigail, BS, Bettencourt, Brian R, PhD, Sutherland, Jessica E, PhD, Hutabarat, Renta M, PhD, Clausen, Valerie A, PhD, Karsten, Verena, PhD, Cehelsky, Jeffrey, MBA, Nochur, Saraswathy V, PhD, Kotelianski, Victor, MD, Horton, Jay, MD, Mant, Timothy, MD, Chiesa, Joseph, MD, Ritter, James, MD, Munisamy, Malathy, MD, Vaishnaw, Akshay K, MD, Gollob, Jared A, MD, Simon, Amy, MD

“…Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that…”
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Safety profile of RNAi nanomedicines by Barros, Scott A., Gollob, Jared A.

“…The emerging class of RNA interference (RNAi) therapeutics is a fundamentally novel approach to treating human disease by enabling the pursuit of molecular…”
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randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus by DeVincenzo, John, Lambkin-Williams, Robert, Wilkinson, Tom, Cehelsky, Jeffrey, Nochur, Sara, Walsh, Edward, Meyers, Rachel, Gollob, Jared, Vaishnaw, Akshay

“…RNA interference (RNAi) is a natural mechanism regulating protein expression that is mediated by small interfering RNAs (siRNA). Harnessing RNAi has potential…”
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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate by Zimmermann, Tracy S., Karsten, Verena, Chan, Amy, Chiesa, Joseph, Boyce, Malcolm, Bettencourt, Brian R., Hutabarat, Renta, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared

“…Advancement of RNAi-based therapeutics depends on effective delivery to the site of protein synthesis. Although intravenously administered, multi-component…”
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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients by Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

“…Background Respiratory syncytial virus (RSV) infection in lung transplant (LTx) patients is associated with an increased incidence of bronchiolitis obliterans…”
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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial by Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.

“…Toll-like receptor–driven and interleukin-1 (IL-1) receptor–driven inflammation mediated by IL-1 receptor–associated kinase 4 (IRAK4) is involved in the…”
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Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study by Suhr, Ole B, Coelho, Teresa, Buades, Juan, Pouget, Jean, Conceicao, Isabel, Berk, John, Schmidt, Hartmut, Waddington-Cruz, Márcia, Campistol, Josep M, Bettencourt, Brian R, Vaishnaw, Akshay, Gollob, Jared, Adams, David

“…Transthyretin-mediated amyloidosis is an inherited, progressively debilitating disease caused by mutations in the transthyretin gene. This study evaluated the…”
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Rapid progression of familial amyloidotic polyneuropathy: A multinational natural history study by Adams, David, Coelho, Teresa, Obici, Laura, Merlini, Giampaolo, Mincheva, Zoia, Suanprasert, Narupat, Bettencourt, Brian R, Gollob, Jared A, Gandhi, Pritesh J, Litchy, William J, Dyck, Peter J

“…OBJECTIVES:To assess the association between severity of neuropathy and disease stage, and estimate the rate of neuropathy progression in a retrospective…”
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RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus by ZAMORA, Martin R, BUDEV, Marie, GOLLOB, Jared A, GLANVILLE, Allan R, ROLFE, Mark, GOTTLIEB, Jens, HUMAR, Atul, DEVINCENZO, John, VAISHNAW, Akshay, CEHELSKY, Jeffrey, ALBERT, Gary, NOCHUR, Sara

“…Lower respiratory tract infections due to respiratory syncytial virus (RSV) are associated with development of bronchiolitis obliterans syndrome in lung…”
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Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy by Adams, David, Suhr, Ole B, Dyck, Peter J, Litchy, William J, Leahy, Raina G, Chen, Jihong, Gollob, Jared, Coelho, Teresa

“…Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive…”
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First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement by Tabernero, Josep, Shapiro, Geoffrey I, LoRusso, Patricia M, Cervantes, Andres, Schwartz, Gary K, Weiss, Glen J, Paz-Ares, Luis, Cho, Daniel C, Infante, Jeffrey R, Alsina, Maria, Gounder, Mrinal M, Falzone, Rick, Harrop, Jamie, White, Amy C Seila, Toudjarska, Iva, Bumcrot, David, Meyers, Rachel E, Hinkle, Gregory, Svrzikapa, Nenad, Hutabarat, Renta M, Clausen, Valerie A, Cehelsky, Jeffrey, Nochur, Saraswathy V, Gamba-Vitalo, Christina, Vaishnaw, Akshay K, Sah, Dinah W Y, Gollob, Jared A, Burris, 3rd, Howard A

“…RNA interference (RNAi) is a potent and specific mechanism for regulating gene expression. Harnessing RNAi to silence genes involved in disease holds promise…”
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A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis by Coelho, Teresa, Adams, David, Conceição, Isabel, Waddington-Cruz, Márcia, Schmidt, Hartmut H, Buades, Juan, Campistol, Josep, Berk, John L, Polydefkis, Michael, Wang, Jing Jing, Chen, Jihong, Sweetser, Marianne T, Gollob, Jared, Suhr, Ole B

“…Abstract Background Patisiran, an RNA interference therapeutic, has demonstrated robust reduction of wild-type and mutant transthyretin protein and was able to…”
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Role of Raf Kinase in Cancer: Therapeutic Potential of Targeting the Raf/MEK/ERK Signal Transduction Pathway by Gollob, Jared A., Wilhelm, Scott, Carter, Chris, Kelley, Susan L.

“…Improvements in our understanding of the molecular basis of cancer have led to the clinical development of protein kinase inhibitors, which target pivotal…”
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Phase II Trial of Sorafenib Plus Interferon Alfa-2b As First- or Second-Line Therapy in Patients With Metastatic Renal Cell Cancer by GOLLOB, Jared A, KIMRYN RATHMELL, W, RICHMOND, Tina M, MARINO, Christine B, MILLER, Elizabeth K, GRIGSON, Gayle, WATKINS, Catharine, LIN GU, PETERSON, Bercedis L, WRIGHT, John J

“…We undertook this study to determine the activity and tolerability of sorafenib administered with interferon alfa-2b (IFN-alpha-2b) as first- or second-line…”
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Safety, Pharmacokinetics, and Activity of ABX-EGF, a Fully Human Anti–Epidermal Growth Factor Receptor Monoclonal Antibody in Patients With Metastatic Renal Cell Cancer by ROWINSKY, Eric K, SCHWARTZ, Garry H, ARENAS, Rosalin, FOON, Kenneth A, SCHWAB, Gisela, DUTCHER, Janice, GOLLOB, Jared A, THOMPSON, John A, VOGELZANG, Nicholas J, FIGLIN, Robert, BUKOWSKI, Ronald, HAAS, Naomi, LOCKBAUM, Pamela, LI, Yu-Ping

“…To determine the antitumor activity of ABX-EGF, a fully human monoclonal antibody to the epidermal growth factor receptor (EGFr), in previously treated…”
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Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma by GOLLOB, Jared A, SCIAMBI, Catherine J, PETERSON, Bercedis L, RICHMOND, Tina, THORESON, Monica, MORAN, Kelly, DRESSMAN, Holly K, JELINEK, Jaroslav, ISSA, Jean-Pierre J

“…Purpose: The silencing of gene expression through DNA methylation contributes to defects in antigen presentation and apoptosis in melanoma and renal cell…”
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Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells by Niemietz, Christoph J, Sauer, Vanessa, Stella, Jacqueline, Fleischhauer, Lutz, Chandhok, Gursimran, Guttmann, Sarah, Avsar, Yesim, Guo, Shuling, Ackermann, Elizabeth J, Gollob, Jared, Monia, Brett P, Zibert, Andree, Schmidt, Hartmut H-J

“…Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the liver. Two compounds that…”
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Decitabine Up-regulates S100A2 Expression and Synergizes with IFN-γ to Kill Uveal Melanoma Cells by GOLLOB, Jared A, SCIAMBI, Catherine J

“…Purpose: Metastatic uveal melanoma is resistant to conventional chemotherapy and immunotherapy. In this study, we investigated the responsiveness of uveal…”
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603 Targeted STAT3 degradation leads to remodeling of an immunosuppressive tumor microenvironment and subsequent sensitization to immune checkpoint therapy by Dey, Joyoti, Liu, Phillip, Mayo, Michele, Karnik, Rahul, Yang, Bin, Dixit, Vaishali, Jeong, Jieun, Gollob, Jared, Savi, Chris De

“…BackgroundSignal Transducer and Activator of Transcription 3 (STAT3), a multifaceted transcription factor, is aberrantly activated across a variety of…”
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Phase I Trial of Concurrent Twice-Weekly Recombinant Human Interleukin-12 Plus Low-Dose IL-2 in Patients With Melanoma or Renal Cell Carcinoma by GOLLOB, Jared A, VEENSTRA, Korina G, PARKER, Robert A, MIER, James W, MCDERMOTT, David F, CLANCY, Daniel, TUTIN, Linda, KOON, Henry, ATKINS, Michael B

“…To maintain interferon gamma (IFNgamma) induction by recombinant human interleukin-12 (rhIL-12) and enhance its activity against melanoma and renal cell…”
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