Search Results - "Goleniewska, K."

Prostaglandin I2 Receptor (IP) Signaling Inhibits Antigen Uptake but Induce the Ability of Migration on Immature Dendritic Cells by Toki, S, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

Get full text

IL-17A-mediated STAT6 Independent Mucus Production in Mice by Boswell, M.G, Newcomb, D.C, Goleniewska, K, Reiss, S, Adler, K.B, Peebles, R.S

Get full text

Prostaglandin I2 Receptor (IP) Signaling Inhibits TLR4 Cell Surface Expression and Reduces LPS-induced Lung Inflammation by Toki, S, Zhou, W, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

Get full text

Attenuated Allergic Airway Inflammation in gp91phox KO Mice is Due to Altered Dendritic Cell Function by Sevin, C.M, Newcomb, D.C, Huckabee, M.M, Goleniewska, K, Blackwell, T.S, Peebles, R.S

Get full text

TGF-β, IL-1β, And IL-23 Are Required For IL-13Rα1 Expression On Human Th17 Cells And IL-13 Attenuates IL-17A Production At Restimulation by Huckabee, M.M, Newcomb, D.C, Boswell, M.G, Goleniewska, K, Reiss, S, Peebles, R.S

Get full text

Il-13 Receptor Alpha 1 Is Expressed On T Cells In Vivo And Il-13 Regulates RSV-Induced Il-17A Production In STAT1-/- Mice by Boswell, M.G, Newcomb, D.C, Huckabee, M.M, Goleniewska, K, Reiss, S.S, Peebles, R.S

Get full text

Prostaglandin I2 Signaling Exacerbates Experimental Autoimmune Encephalomyelitis by Dowell, D.R, Zhou, W, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, Fitzgerald, G.A, Peebles, R.S

Get full text

The Deficiency of PGI2 Signaling Induces STAT6-independent Allergic Airway Inflammation by Zhou, W, Dowell, D.R, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, FitzGerald, G, Peebles, R.S

Get full text

Human CD4+ Th17 Cells Express A Functional IL-13 Receptor And IL-13 Signaling Negatively Regulates IL-17A Production by Newcomb, D.C, Zhou, W, Goleniewska, K, Peebles, R.S

“…Naïve CD4+ cells were isolated from blood, activated with anti-CD3 and anti-CD28, and polarized into Th17 cells using IL-2, TGF-β, IL-1β, IL-6, IL-23,…”
Get full text

IL-13 Decreases IL-17a Production In Mouse Th17 Cells Through An IL-10 Dependent Mechanism by Newcomb, D.C, Huckabee, M.M, Boswell, M.G, Goleniewska, K, Reiss, S.S, Peebles, R.S

“…When Th17 cells were polarized in the presence of IL-13, anti-IL-10 prevented the IL-13-mediated decrease in Th17 cytokine production. p<0.05, n=5-8 for all…”
Get full text

Signaling through the PGI2 Receptor Promotes IL-17 Production by CD4 T Cells by Huckabee, M.M, Zhou, W, Newcomb, D.C, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

“…The effect of iloprost and cicaprost on IL-17 production by IP KO/OT II T cells was significantly attenuated compared to the effect on control OT II T cells…”
Get full text

Lack of p47phox , the Active Subunit of the NADPH Oxidase Complex, Augments Ovalbumin-induced Allergic Airway Inflammation in Mice by Sevin, C.M, Newcomb, D.C, Goleniewska, K, Blackwell, T.S, Peebles, R.S

“…[...]we hypothesized that p47phox knockout (KO) mice would have decreased ovalbumin (OVA)-induced allergic inflammation compared to wild type (WT) mice…”
Get full text

PGE2 in Synergy with IL-23 Drives Robust IL-17 Production and Th17 Differentiation by Inhibiting the STAT6 Signaling Pathway by Zhou, W, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, Ji, S, Breyer, R.M, Peebles, R.S

“…Frequent use of cyclooxygenase-inhibiting and PGE2-suppressing drugs may disturb the balance of Th lineages in the immune system and affect the host defense…”
Get full text

PGE2 And EP2 Receptor Signaling Suppress IL-17 Production By Polarized Mouse Th17 Cells by Zhou, W, Newcomb, D.C, Goleniewska, K, Moore, M.L, Peelbes, R.S

“…When CD4 T cells of EP2 deficient mice were used for the experiments, the suppressive effect on IL-17 production was significantly attenuated, indicating that…”
Get full text

A Functional IL-13 Receptor is Expressed on Polarized Murine CD4 + Th17 Cells and IL-13 Signaling Negatively Regulates Th17 Cytokine Production by Newcomb, D.C, Zhou, W, Moore, M.L, Goleniewska, K, Hershey, G.K.K, Kolls, J.K, Peebles, R.S

“…IL-13 also negatively regulates IL-17A and IL-21 production. [...]using therapeutics to inhibit IL-13 production could have adverse consequences by…”
Get full text

STAT1 Negatively Regulates Basophil IL-4 Expression Induced by Respiratory Syncytial Vrus Infection by Moore, M.L, Parekh, V.V, Van Kaer, L, Collins, R.D, Goleniewska, K, Chi, M.H, Mitchell, D, Durbin, J.E, Peebles, R.S

“…RSV infection resulted in more IL-4-expressing basophils in the lungs of STAT1-/- mice than in wild-type BALB/c mice.We ruled out NK cells, NKT cells, mast…”
Get full text

Respiratory Syncytial Virus Infections Augment Allergen-Specific T Cell Secretion of Lung IL-17A by Newcomb, D.C, Moore, M.L, Goleniewska, K, Zhou, W, Peebles, R.S

“…Conclusions RSV infection augments the allergen-specific T cell production of lung IL-17A and therefore fundamentally changes the immune response against an…”
Get full text

A Clinical Isolate Strain of Respiratory Syncytial Virus (RSV) Causes Airway Obstruction and Histopathology in Mice Similar to Severe RSV Disease in Infants by Moore, M.L, Chi, M.H, Williams, J.V, Wright, P.F, Crowe, J.E, Edwards, K.M, Polosukhin, V.V, Goleniewska, K, Peebles, R.S

“…A/Nashville/2001/2-20 infection caused high lung IL-13 and mucus levels, epithelial cell damage, and smooth muscle damage and hyperplasia in BALB/c mice…”
Get full text

Natural Killer (NK) Cells, Not T Cells, Produce the Cytokine IL-4 in Response to Primary Respiratory Syncytial Virus Infection by Moore, M.L, Parekh, V.V, Van Kaer, L, Collins, R.D, Goleniewska, K, O'Neal, J.F, Chi, M.H, Durbin, J.E, Peebles, R.S

“…[...]experiments in STAT1-deficient mice revealed a 2.5-fold increase in the number of NK cells expressing IL-4 in response to RSV infection, compared to…”
Get full text

Respiratory Syncytial Virus-Induced Airway Dysfunction Depends on the Virus Strain by Moore, M.L., Lukacs, N.W., Rudd, B.D., Polosukhin, V.V., Chi, M.H., Goleniewska, K., O'Neal, J.F., Peebles, R.S.

“…Two RSV strains elicited different pulmonary immune responses and induced differential airway dysfunction and mucus production in mice…”
Get full text