Search Results - "Golec, Dominic P."

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells by Santer, Deanna M, Minty, Gillian E S, Golec, Dominic P, Lu, Julia, May, Julia, Namdar, Afshin, Shah, Juhi, Elahi, Shokrollah, Proud, David, Joyce, Michael, Tyrrell, D Lorne, Houghton, Michael

“…Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB…”
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Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes by Campbell, Scott A., Golec, Dominic P., Hubert, Matt, Johnson, Janyne, Salamon, Nicole, Barr, Amy, MacDonald, Patrick E., Philippaert, Koenraad, Light, Peter E.

“…Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology…”
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PI3K in T Cell Adhesion and Trafficking by Johansen, Kristoffer H, Golec, Dominic P, Thomsen, Julie H, Schwartzberg, Pamela L, Okkenhaug, Klaus

“…PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively…”
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Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13–driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells by Gazzinelli-Guimaraes, Pedro H., Golec, Dominic P., Karmele, Erik P., Sciurba, Joshua, Bara-Garcia, Pablo, Hill, Tom, Kang, Byunghyun, Bennuru, Sasisekhar, Schwartzberg, Pamela L., Nutman, Thomas B.

“…The immunologic mechanisms underlying pulmonary type 2 inflammation, including the dynamics of eosinophil recruitment to the lungs, still need to be…”
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RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4 by Golec, Dominic P, Dower, Nancy A, Stone, James C, Baldwin, Troy A

“…T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the…”
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Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion by Johansen, Kristoffer H., Golec, Dominic P., Okkenhaug, Klaus, Schwartzberg, Pamela L.

“…The RASA2 and RASA3 GTPase-activating proteins are recently recognized negative regulators of T cell activation and adhesion.RASA2 was identified as a novel…”
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TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation by Pichler, Andrea C., Carrié, Nadège, Cuisinier, Marine, Ghazali, Samira, Voisin, Alison, Axisa, Pierre-Paul, Tosolini, Marie, Mazzotti, Céline, Golec, Dominic P., Maheo, Sabrina, do Souto, Laura, Ekren, Rüçhan, Blanquart, Eve, Lemaitre, Lea, Feliu, Virginie, Joubert, Marie-Véronique, Cannons, Jennifer L., Guillerey, Camille, Avet-Loiseau, Hervé, Watts, Tania H., Salomon, Benoit L., Joffre, Olivier, Grinberg-Bleyer, Yenkel, Schwarzberg, Pamela L., Lucca, Liliana E., Martinet, Ludovic

“…CD137 (4-1BB)-activating receptor represents a promising cancer immunotherapeutic target. Yet, the cellular program driven by CD137 and its role in cancer…”
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Thymic progenitors of TCRαβ + CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development by Golec, Dominic P, Hoeppli, Romy E, Henao Caviedes, Laura M, McCann, Jillian, Levings, Megan K, Baldwin, Troy A

“…Strong T cell receptor (TCR) signaling largely induces cell death during thymocyte development, whereas weak TCR signals induce positive selection. However,…”
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γδ Thymocyte Maturation and Emigration in Adult Mice by Joannou, Kevin, Golec, Dominic P, Wang, Haiguang, Henao-Caviedes, Laura M, May, Julia F, Kelly, Rees G, Chan, Rigel, Jameson, Stephen C, Baldwin, Troy A

“…Several unique waves of γδ T cells are generated solely in the fetal/neonatal thymus, whereas additional γδ T cell subsets are generated in adults. One…”
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Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis by Ogishi, Masato, Yang, Rui, Rodriguez, Rémy, Golec, Dominic P, Martin, Emmanuel, Philippot, Quentin, Bohlen, Jonathan, Pelham, Simon J, Arias, Andrés Augusto, Khan, Taushif, Ata, Manar, Al Ali, Fatima, Rozenberg, Flore, Kong, Xiao-Fei, Chrabieh, Maya, Laine, Candice, Lei, Wei-Te, Han, Ji Eun, Seeleuthner, Yoann, Kaul, Zenia, Jouanguy, Emmanuelle, Béziat, Vivien, Youssefian, Leila, Vahidnezhad, Hassan, Rao, V Koneti, Neven, Bénédicte, Fieschi, Claire, Mansouri, Davood, Shahrooei, Mohammad, Pekcan, Sevgi, Alkan, Gulsum, Emiroğlu, Melike, Tokgöz, Hüseyin, Uitto, Jouni, Hauck, Fabian, Bustamante, Jacinta, Abel, Laurent, Keles, Sevgi, Parvaneh, Nima, Marr, Nico, Schwartzberg, Pamela L, Latour, Sylvain, Casanova, Jean-Laurent, Boisson-Dupuis, Stéphanie

“…Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB…”
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A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells by Johansen, Kristoffer H, Golec, Dominic P, Huang, Bonnie, Park, Chung, Thomsen, Julie H, Preite, Silvia, Cannons, Jennifer L, Garçon, Fabien, Schrom, Edward C, Courrèges, Christina J F, Veres, Tibor Z, Harrison, James, Nus, Meritxell, Phelan, James D, Bergmeier, Wolfgang, Kehrl, John H, Okkenhaug, Klaus, Schwartzberg, Pamela L

“…The integrin lymphocyte function-associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with…”
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RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors by Golec, Dominic P, Henao Caviedes, Laura M, Baldwin, Troy A

“…T cell development is dependent on the migration of progenitor cells from the bone marrow to the thymus. Upon reaching the thymus, progenitors undergo a…”
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IL-2 rescues impaired T cell function upon loss of Itk via metabolic reprogramming by Kaul, Zenia, Gomez-Rodriguez, Julio, Golec, Dominic P, Reilley, Julie, Schwartzberg, Pamela L

“…IL-2 inducible T cell kinase (Itk) is a critical component of T cell receptor (TCR) signaling required for activation of PLCg and downstream transcription…”
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CRISPR screening for cytotoxic granule degranulation pathway in CD8 T cell by Shibata, Hirofumi, Golec, Dominic P, Phelan, James, Johansen, Kristoffer, Huang, Bonnie, Schwartzberg, Pamela L

“…Degranulation of perforin-containing cytotoxic granules is important for NK cells and CD8 cytotoxic T lymphocytes (CTLs) to kill infected cells or tumors…”
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PI3Kδ: a key driver of effector differentiation under conditions of T cell exhaustion by Pichler, Andrea C, Cannons, Jennifer L, Golec, Dominic P, Reilley, Julie, McGavern, Dorian B, Schwartzberg, Pamela L

“…In chronic infection and cancer, prolonged antigen exposure drives a state of T cell hyporesponsiveness, called exhaustion. A small subset of TCF1 +progenitor…”
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PI3Kδ shapes Th2 lineage restriction through coordination of IL-2 signaling, Foxo1 inactivation and epigenetic remodeling by Golec, Dominic P, Gazzinelli-Guimaraes, Pedro, Chauss, Daniel, Hill, Tom, Nivelo, Luis, Joshi, Ilin, Pereira, Nicolas, Druey, Kirk M, Lack, Justin, Afzali, Behdad, Villarino, Alejandro, Nutman, Thomas B, Schwartzberg, Pamela L

“…Activated PI3K-delta syndrome (APDS) is a primary immunodeficiency caused by heterozygous activating mutations in PI3Kδ, resulting in recurrent infections as…”
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RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic [beta]-Selection and ERK Activation Downstream of CXCR4 by Golec, Dominic P, Dower, Nancy A, Stone, James C, Baldwin, Troy A

“…T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the…”
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