Search Results - "Goldstein, Peter"

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment by Safavynia, Seyed A, Goldstein, Peter A

“…Postoperative cognitive dysfunction (POCD) is a common complication of the surgical experience and is common in the elderly and patients with preexisting…”
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The ethics of quality improvement studies: do the needs of the many outweigh the needs of the few? by Goldstein, Peter A

“…Clinical research involving human subjects and quality improvement (QI) projects share a common goal of seeking to improve human health, whether by directly…”
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Ethical considerations for theatre teams in organ donation after circulatory determination of death by Lennon, Christine, Harvey, Dan, Goldstein, Peter A

“…Transplant surgery is an area that gives rise to a number of ethical considerations. As medicine continues to expand the boundaries of what is technically…”
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Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells by Maroof, Asif M., Keros, Sotirios, Tyson, Jennifer A., Ying, Shui-Wang, Ganat, Yosif M., Merkle, Florian T., Liu, Becky, Goulburn, Adam, Stanley, Edouard G., Elefanty, Andrew G., Widmer, Hans Ruedi, Eggan, Kevin, Goldstein, Peter A., Anderson, Stewart A., Studer, Lorenz

“…Human pluripotent stem cells are a powerful tool for modeling brain development and disease. The human cortex is composed of two major neuronal populations:…”
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NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells by Tchieu, Jason, Calder, Elizabeth L., Guttikonda, Sudha R., Gutzwiller, Eveline M., Aromolaran, Kelly A., Steinbeck, Julius A., Goldstein, Peter A., Studer, Lorenz

“…The mechanistic basis of gliogenesis, which occurs late in human development, is poorly understood. Here we identify nuclear factor IA (NFIA) as a molecular…”
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Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? by Tibbs, Gareth R, Posson, David J, Goldstein, Peter A

“…Neuropathic pain arises from injury to the nervous system. Conditions associated with neuropathic pain are diverse, and lesions and/or pathological changes in…”
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Nonhuman Primates in Anesthesia Research: Have We Reached the End of the Road? by Goldstein, Peter A.

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Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease by Steinbeck, Julius A., Jaiswal, Manoj K., Calder, Elizabeth L., Kishinevsky, Sarah, Weishaupt, Andreas, Toyka, Klaus V., Goldstein, Peter A., Studer, Lorenz

“…Capturing the full potential of human pluripotent stem cell (PSC)-derived neurons in disease modeling and regenerative medicine requires analysis in complex…”
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Obesity as a risk factor for poor outcome in COVID-19-induced lung injury: the potential role of undiagnosed obstructive sleep apnoea by Memtsoudis, Stavros G, Ivascu, Natalia S, Pryor, Kane O, Goldstein, Peter A

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Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery by Hemmings, Hugh C., Riegelhaupt, Paul M., Kelz, Max B., Solt, Ken, Eckenhoff, Roderic G., Orser, Beverley A., Goldstein, Peter A.

“…Significant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident…”
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HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore by Goldstein, Peter A.

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An epigenetic barrier sets the timing of human neuronal maturation by Ciceri, Gabriele, Baggiolini, Arianna, Cho, Hyein S., Kshirsagar, Meghana, Benito-Kwiecinski, Silvia, Walsh, Ryan M., Aromolaran, Kelly A., Gonzalez-Hernandez, Alberto J., Munguba, Hermany, Koo, So Yeon, Xu, Nan, Sevilla, Kaylin J., Goldstein, Peter A., Levitz, Joshua, Leslie, Christina S., Koche, Richard P., Studer, Lorenz

“…The pace of human brain development is highly protracted compared with most other species 1 – 7 . The maturation of cortical neurons is particularly slow,…”
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Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells by Lafaille, Fabien G., Pessach, Itai M., Zhang, Shen-Ying, Ciancanelli, Michael J., Herman, Melina, Abhyankar, Avinash, Ying, Shui-Wang, Keros, Sotirios, Goldstein, Peter A., Mostoslavsky, Gustavo, Ordovas-Montanes, Jose, Jouanguy, Emmanuelle, Plancoulaine, Sabine, Tu, Edmund, Elkabetz, Yechiel, Al-Muhsen, Saleh, Tardieu, Marc, Schlaeger, Thorsten M., Daley, George Q., Abel, Laurent, Casanova, Jean-Laurent, Studer, Lorenz, Notarangelo, Luigi D.

“…Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to…”
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Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability by Inan, Melis, Zhao, Mingrui, Manuszak, Monica, Karakaya, Cansu, Rajadhyaksha, Anjali, Pickel, Virginia M, Schwartz, Theodore H, Goldstein, Peter A, Manfredi, Giovanni

“…Abstract Parvalbumin-expressing, fast spiking interneurons have high-energy demands, which make them particularly susceptible to energy impairment. Recent…”
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Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy: Cause and effect? by Aromolaran, Kelly A, Goldstein, Peter A

“…Cancer is the second leading cause of death worldwide and is a major global health burden. Significant improvements in survival have been achieved, due in part…”
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Mitigation of perioperative neurocognitive disorders: A holistic approach by Safavynia, Seyed A., Goldstein, Peter A., Evered, Lisbeth A.

“…William Morton introduced the world to ether anesthesia for use during surgery in the Bullfinch Building of the Massachusetts General Hospital on October 16,…”
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Non-canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels by Cook, Daniel C, Goldstein, Peter A

“…Pain is a prevalent biopsychosocial condition that poses a significant challenge to healthcare providers, contributes substantially to a disability, and is a…”
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Editorial: CNS pain circuits in health and disease by Ferrini, Francesco, Goldstein, Peter A., Labrakakis, Charalampos

“…[...]plastic alterations in the function of these circuits can lead to altered pain perception, notably hypersensitivity and allodynia, which are hallmarks of…”
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Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants by Kim, Elizabeth D., Wu, Xiaoan, Lee, Sangyun, Tibbs, Gareth R., Cunningham, Kevin P., Di Zanni, Eleonora, Perez, Marta E., Goldstein, Peter A., Accardi, Alessio, Larsson, H. Peter, Nimigean, Crina M.

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels 1 are essential for pacemaking activity and neural signalling 2 , 3 . Drugs inhibiting HCN1…”
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Perturbation of HCN1 response to small molecule modulation by Kim, Elizabeth D., Falzone, Maria E., Tibbs, Gareth R., Ferrer, Matthew, Goldstein, Peter A., Nimigean, Crina M.

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