Search Results - "Goldstein, Leslie A."

Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis by Hou, Wen, Han, Jie, Lu, Caisheng, Goldstein, Leslie A., Rabinowich, Hannah

“…Apoptotic defects endow tumor cells with survival advantages. Such defects allow the cellular stress response to take the path of cytoprotective autophagy,…”
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Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells by Han, Jie, Hou, Wen, Goldstein, Leslie A., Lu, Caisheng, Stolz, Donna B., Yin, Xiao-Ming, Rabinowich, Hannah

“…Targeting TRAIL receptors with either recombinant TRAIL or agonistic DR4- or DR5-specific antibodies has been considered a promising treatment for cancer,…”
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Interrelated Roles for Mcl-1 and BIM in Regulation of TRAIL-mediated Mitochondrial Apoptosis by Han, Jie, Goldstein, Leslie A., Gastman, Brian R., Rabinowich, Hannah

“…The current study demonstrates a novel cross-talk mechanism between the TRAIL receptor death signaling pathway and the mitochondria. This newly identified…”
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Regulation of Mitochondrial Apoptotic Events by p53-mediated Disruption of Complexes between Antiapoptotic Bcl-2 Members and Bim by Han, Jie, Goldstein, Leslie A., Hou, Wen, Gastman, Brian R., Rabinowich, Hannah

“…Multiple mechanisms have been proposed for the mitochondrial function of p53 that are either dependent on or independent of its transcriptional activity…”
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Deregulation of Mitochondrial Membrane Potential by Mitochondrial Insertion of Granzyme B and Direct Hax-1 Cleavage by Han, Jie, Goldstein, Leslie A., Hou, Wen, Froelich, Christopher J., Watkins, Simon C., Rabinowich, Hannah

“…The cytoplasm and the nucleus have been identified as activity sites for granzyme B (GrB) following its delivery from cytotoxic lymphocyte granules into target…”
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Functional Linkage between NOXA and Bim in Mitochondrial Apoptotic Events by Han, Jie, Goldstein, Leslie A., Hou, Wen, Rabinowich, Hannah

“…NOXA is a BH3-only protein whose expression is induced by certain p53-depenent or independent apoptotic stimuli. Both NOXA and Bim are avid binders of Mcl-1,…”
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Regulation of Fibroblast Migration on Collagenous Matrix by a Cell Surface Peptidase Complex by Ghersi, Giulio, Dong, Huan, Goldstein, Leslie A, Yeh, Yunyun, Hakkinen, Lari, Larjava, Hannu S, Chen, Wen-Tien

“…The invasion of migratory cells through connective tissues involves metallo- and serine types of cell surface proteases. We show that formation of a novel…”
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Enhancement of tumor-TRAIL susceptibility by modulation of autophagy by Hou, Wen, Han, Jie, Lu, Caisheng, Goldstein, Leslie A., Rabinowich, Hannah

“…Autophagy has recently been recognized as an important cellular response to stress. However, the prospect of manipulating the autophagic process for the…”
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Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport by Han, Jie, Goldstein, Leslie A., Hou, Wen, Watkins, Simon C., Rabinowich, Hannah

“…Recently, we reported that increased expression of CASP9 pro-domain, at the endosomal membrane in response to HSP90 inhibition, mediates a cell-protective…”
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A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS by Han, Jie, Hou, Wen, Goldstein, Leslie A, Stolz, Donna B, Watkins, Simon C, Rabinowich, Hannah

“…Several cross-talk mechanisms between autophagy and apoptosis have been identified, in which certain co-regulators are shared, allowing the same protein to…”
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HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC by Han, Jie, Goldstein, Leslie A., Hou, Wen, Chatterjee, Suman, Burns, Timothy F., Rabinowich, Hannah

“…Macroautophagy/autophagy has emerged as a resistance mechanism to anticancer drug treatments that induce metabolic stress. Certain tumors, including a subset…”
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Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation by Han, Jie, Hou, Wen, Lu, Caisheng, Goldstein, Leslie A., Stolz, Donna B., Watkins, Simon C., Rabinowich, Hannah

“…Beclin-1 is a key regulator of autophagy that functions in the context of two phase-specific complexes in the initiation and maturation of autophagosomes. Its…”
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Molecular cloning of seprase: a serine integral membrane protease from human melanoma by Goldstein, Leslie A, Ghersi, Giulio, Piñeiro-Sánchez, Mayra L, Monica Salamone, Yeh, Yunyun, Flessate, Denise, Chen, Wen-Tien

“…Seprase is a homodimeric 170 kDa integral membrane gelatinase whose expression correlates with the invasiveness of the human melanoma cell line LOX. Here, we…”
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Disruption of Mcl-1·Bim Complex in Granzyme B-mediated Mitochondrial Apoptosis by Han, Jie, Goldstein, Leslie A., Gastman, Brian R., Rabinovitz, Asaf, Rabinowich, Hannah

“…Recently, we reported the identification of a novel mitochondrial apoptotic pathway for granzyme B (GrB) (Han, J., Goldstein, L. A., Gastman, B. R., Froelich,…”
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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events by Han, Jie, Goldstein, Leslie A, Gastman, Brian R, Froelich, Christopher J, Yin, Xiao-Ming, Rabinowich, Hannah

“…Recent studies have suggested that in the absence of Bid, granzyme B (GrB) can utilize an unknown alternative pathway to mediate mitochondrial apoptotic…”
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A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs by Wang, Gui-Qiang, Gastman, Brian R., Wieckowski, Eva, Goldstein, Leslie A., Gambotto, Andrea, Kim, Tae-Hyoung, Fang, Bingliang, Rabinovitz, Asaf, Yin, Xiao-Ming, Rabinowich, Hannah

“…In the present study a clonal Jurkat cell line deficient in expression of Bak was used to analyze the role of Bak in cytochrome c release from mitochondria…”
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Granzyme B-mediated degradation of T-cell receptor ζ chain by WIECKOWSKI, Eva, WANG, Gui-Oiang, GASTMAN, Brian R, GOLDSTEIN, Leslie A, RABINOWICH, Hannah

“…We recently reported that the T-cell receptor (TCR)-zeta chain is cleaved by caspase-3 and -7 in apoptotic T lymphocytes or in a cell-free system. We report…”
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Identification of the 170-kDa Melanoma Membrane-bound Gelatinase (Seprase) as a Serine Integral Membrane Protease by Piñeiro-Sánchez, Mayra L., Goldstein, Leslie A., Dodt, Johannes, Howard, Linda, Yeh, Yunyun, Chen, Wen-Tien

“…The 170-kDa membrane-bound gelatinase, seprase, is a cell surface protease, the expression of which correlates with the invasive phenotype of human melanoma…”
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Identification of an Alternatively Spliced Seprase mRNA That Encodes a Novel Intracellular Isoform by Goldstein, Leslie A., Chen, Wen-Tien

“…Seprase is a homodimeric 170-kDa integral membrane gelatinase that is related to the ectoenzyme dipeptidyl peptidase IV. We have identified an alternatively…”
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A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins by Goldstein, L A, Zhou, D F, Picker, L J, Minty, C N, Bargatze, R F, Ding, J F, Butcher, E C

“…Lymphocyte interactions with high endothelial venules (HEV) during extravasation into lymphoid tissues involve an 85-95 kd class of lymphocyte surface…”
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