Search Results - "Goldstein, Lawrence S B"

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells by Israel, Mason A., Yuan, Shauna H., Bardy, Cedric, Reyna, Sol M., Mu, Yangling, Herrera, Cheryl, Hefferan, Michael P., Van Gorp, Sebastiaan, Nazor, Kristopher L., Boscolo, Francesca S., Carson, Christian T., Laurent, Louise C., Marsala, Martin, Gage, Fred H., Remes, Anne M., Koo, Edward H., Goldstein, Lawrence S. B.

“…Induced pluripotent stem cells are shown to be useful for studying phenotypes relevant to familial and sporadic Alzheimer’s disease, even though it can take…”
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Somatic coding mutations in human induced pluripotent stem cells by Gore, Athurva, Li, Zhe, Fung, Ho-Lim, Young, Jessica E., Agarwal, Suneet, Antosiewicz-Bourget, Jessica, Canto, Isabel, Giorgetti, Alessandra, Israel, Mason A., Kiskinis, Evangelos, Lee, Je-Hyuk, Loh, Yuin-Han, Manos, Philip D., Montserrat, Nuria, Panopoulos, Athanasia D., Ruiz, Sergio, Wilbert, Melissa L., Yu, Junying, Kirkness, Ewen F., Belmonte, Juan Carlos Izpisua, Rossi, Derrick J., Thomson, James A., Eggan, Kevin, Daley, George Q., Goldstein, Lawrence S. B., Zhang, Kun

“…Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells into induced pluripotent stem cells. Although DNA factors are…”
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Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells by Yuan, Shauna H, Martin, Jody, Elia, Jeanne, Flippin, Jessica, Paramban, Rosanto I, Hefferan, Mike P, Vidal, Jason G, Mu, Yangling, Killian, Rhiannon L, Israel, Mason A, Emre, Nil, Marsala, Silvia, Marsala, Martin, Gage, Fred H, Goldstein, Lawrence S B, Carson, Christian T

“…Neural induction of human pluripotent stem cells often yields heterogeneous cell populations that can hamper quantitative and comparative analyses. There is a…”
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Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury by Lu, Paul, Woodruff, Grace, Wang, Yaozhi, Graham, Lori, Hunt, Matt, Wu, Di, Boehle, Eileen, Ahmad, Ruhel, Poplawski, Gunnar, Brock, John, Goldstein, Lawrence S.B., Tuszynski, Mark H.

“…Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient…”
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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease by Stokin, Gorazd B, Lillo, Concepción, Falzone, Tomás L, Brusch, Richard G, Rockenstein, Edward, Mount, Stephanie L, Raman, Rema, Davies, Peter, Masliah, Eliezer, Williams, David S, Goldstein, Lawrence S. B

“…We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar…”
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ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia by Jiang, Qingfei, Crews, Leslie A., Barrett, Christian L., Chun, Hye-Jung, Court, Angela C., Isquith, Jane M., Zipeto, Maria A., Goff, Daniel J., Minden, Mark, Sadarangani, Anil, Rusert, Jessica M., Dao, Kim-Hien T., Morris, Sheldon R., Goldstein, Lawrence S. B., Marra, Marco A., Frazer, Kelly A., Jamieson, Catriona H. M.

“…The molecular etiology of human progenitor reprogramming into self-renewing leukemia stem cells (LSC) has remained elusive. Although DNA sequencing has…”
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Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin by Her, Lu-Shiun, Goldstein, Lawrence S. B

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disease linked to a polyQ (polyglutamine) expansion in the huntingtin protein. Although…”
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The genetics of axonal transport and axonal transport disorders by Duncan, Jason E, Goldstein, Lawrence S B

“…Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to…”
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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice by Yamanaka, Koji, Boillee, Severine, Roberts, Elizabeth A, Garcia, Michael L, McAlonis-Downes, Melissa, Mikse, Oliver R, Cleveland, Don W, Goldstein, Lawrence S.B

“…Dominant mutations in ubiquitously expressed superoxide dismutase (SOD1) cause familial ALS by provoking premature death of adult motor neurons. To test…”
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Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease by Valdes, Phoebe, Henry, Kenneth W, Fitzgerald, Michael Q, Muralidharan, Koushik, Caldwell, Andrew B, Ramachandran, Srinivasan, Goldstein, Lawrence S B, Mobley, William C, Galasko, Douglas R, Subramaniam, Shankar

“…Non-familial Alzheimer's disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer's disease (EOAD) and constitutes ~ 5-6%…”
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Endogenous GSK‐3/Shaggy Regulates Bidirectional Axonal Transport of the Amyloid Precursor Protein by Weaver, Carole, Leidel, Christina, Szpankowski, Lukasz, Farley, Nicole M., Shubeita, George T., Goldstein, Lawrence S. B.

“…Neurons rely on microtubule (MT) motor proteins such as kinesin‐1 and dynein to transport essential cargos between the cell body and axon terminus. Defective…”
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Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1 by ORDONEZ, M. Paulina, ROBERTS, Elizabeth A, KIDWELL, Chelsea U, YUAN, Shauna H, PLAISTED, Warren C, GOLDSTEIN, Lawrence S. B

“…An unresolved issue about many neurodegenerative diseases is why neurons are particularly sensitive to defects in ubiquitous cellular processes. One example is…”
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The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila by Duncan, Jason E, Lytle, Nikki K, Zuniga, Alfredo, Goldstein, Lawrence S B

“…Axonal transport, a form of long-distance, bi-directional intracellular transport that occurs between the cell body and synaptic terminal, is critical in…”
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Investigating synapse formation and function using human pluripotent stem cell-derived neurons by Kim, Ji-Eun, O'Sullivan, Matthew L, Sanchez, Christopher A, Hwang, Minju, Israel, Mason A, Brennand, Kristen, Deerinck, Thomas J, Goldstein, Lawrence S.B, Gage, Fred H, Ellisman, Mark H, Ghosh, Anirvan

“…A major goal of stem-cell research is to identify conditions that reliably regulate their differentiation into specific cell types. This goal is particularly…”
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Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles by Szpankowski, Lukasz, Encalada, Sandra E, Goldstein, Lawrence S. B

“…Intracellular transport of vesicles and organelles along microtubules is powered by kinesin and cytoplasmic dynein molecular motors. Both motors can attach to…”
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Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies by Falzone, Tomás L., Gunawardena, Shermali, McCleary, David, Reis, Gerald F., Goldstein, Lawrence S.B.

“…Neurodegeneration induced by abnormal hyperphosphorylation and aggregation of the microtubule-associated protein tau defines neurodegenerative tauopathies…”
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Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles by Abe, Namiko, Almenar-Queralt, Angels, Lillo, Concepcion, Shen, Zhouxin, Lozach, Jean, Briggs, Steven P., Williams, David S., Goldstein, Lawrence S.B., Cavalli, Valeria

“…The extreme polarized morphology of neurons poses a challenging problem for intracellular trafficking pathways. The distant synaptic terminals must communicate…”
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Why we need fetal tissue research by Temple, Sally, Goldstein, Lawrence S B

“…A vocal minority in the United States is intent on stopping federal funding for research using human fetal tissue, citing stem cell–based or other alternatives…”
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Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism by Killian, Rhiannon L, Flippin, Jessica D, Herrera, Cheryl M, Almenar-Queralt, Angels, Goldstein, Lawrence S B

“…The etiology of sporadic Alzheimer disease (AD) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (Aβ) and…”
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Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers by Liu, Qing, Waltz, Shannon, Woodruff, Grace, Ouyang, Joe, Israel, Mason A, Herrera, Cheryl, Sarsoza, Floyd, Tanzi, Rudolph E, Koo, Edward H, Ringman, John M, Goldstein, Lawrence S B, Wagner, Steven L, Yuan, Shauna H

“…Although considerable effort has been expended developing drug candidates for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to…”
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