Search Results - "Goldsmith, Merrill E."

The Histone Deacetylase Inhibitor FK228 Preferentially Enhances Adenovirus Transgene Expression in Malignant Cells by GOLDSMITH, Merrill E, KITAZONO, Masaki, FOK, Patrick, AIKOU, Takashi, BATES, Susan, FOJO, Tito

“…Purpose: Efficient adenovirus infection requires coxsackie-adenovirus receptor (CAR) and α v integrin. Whereas many malignant cells express these proteins…”
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The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems by Goldsmith, Merrill E, Aguila, Alian, Steadman, Kenneth, Martinez, Alfredo, Steinberg, Seth M, Alley, Michael C, Waud, William R, Bates, Susan E, Fojo, Tito

“…A major limitation of adenovirus type 5–mediated cancer gene therapy is the inefficient infection of many cancer cells. Previously, we showed that treatment…”
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Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells by Kitazono, Masaki, Rao, Vemulkonda Koneti, Robey, Rob, Aikou, Takashi, Bates, Susan, Fojo, Tito, Goldsmith, Merrill E.

“…Adenovirus infection of hematopoietic cells frequently requires high virus concentrations and long incubation times to obtain moderate infection levels because…”
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294. The Histone Deacetylase Inhibitor FK228 Increases Histone Acetylation, Coxsackie Adenovirus Receptor Levels and Adenovirus Transgene Expression in Human LOX IMVI Melanoma Xenografts by Goldsmith, Merrill E., Steadman, Kenneth, Aguila, Alian, Alley, Michael C., Waud, William R., Bates, Susan, Fojo, Tito

“…Adenovirus gene therapy is frequently inefficient because of low levels of coxsackie adenovirus receptor (CAR) the primary adenovirus receptor. Previously, we…”
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Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line (∗) by Goldsmith, Merrill E., Gudas, Jean M., Schneider, Erasmus, Cowan, Kenneth H.

“…The effect of human wild type and mutant p53 proteins on the human multidrug resistance (MDR1) promoter was studied in a p53-negative human cell line…”
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Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228 by KITAZONO, Masaki, GOLDSMITH, Merrill E, AIKOU, Takashi, BATES, Susan, FOJO, Tito

“…The presence of coxsackie and adenovirus receptor (CAR) and alpha(v) integrin on cell surfaces is required for efficient adenovirus infection. Treatment of…”
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Adsorption protein of the bacteriophage fd: isolation, molecular properties, and location in the virus by Goldsmith, Merrill E, Konigsberg, William H

“…The adsorption (minor coat) protein of the bacteriophage fd has been implicated to function in several steps of viral morphogenesis. The protein has been…”
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Isolation of amplified and overexpressed DNA sequences from adriamycin resistant human breast cancer cells by FAIRCHILD, C. R, PERCY IVY, S, CHIEN-SONG KAO-SHAN, WHANG-PENG, J, ROSEN, N, ISRAEL, M. A, MELERA, P. W, COWAN, K. H, GOLDSMITH, M. E

“…An MCF-7 human breast cancer cell line was selected which was 200-fold more resistant to Adriamycin than the wild type cell line. This Adriamycin-resistant…”
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Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo by MADDEN, M. J, MORROW, C. S, NAKAGAWA, M, GOLDSMITH, M. E, FAIRCHILD, C. R, COWAN, K. H

“…The human mdr1 gene encodes a putative drug efflux pump (P-glycoprotein) whose overexpression is associated with the development of multidrug resistance (MDR)…”
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Carcinogen-Induced mdr Overexpression is Associated with Xenobiotic Resistance in Rat Preneoplastic Liver Nodules and Hepatocellular Carcinomas by Fairchild, Craig R., Ivy, S. Percy, Rushmore, Thomas, Lee, George, Koo, Paul, Goldsmith, Merrill E., Myers, Charles E., Farber, Emmanuel, Cowan, Kenneth H.

“…We have previously reported the isolation of a human breast cancer cell line resistant to doxorubicin (adriamycin; AdrR MCF-7 cells) that has also developed…”
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Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells by MORROW, C. S, NAKAGAWA, M, GOLDSMITH, M. E, MADDEN, M. J, COWAN, K. H

“…We investigated the mechanism of sodium butyrate (NaB)-mediated induction of mdr1 mRNA in parental (wild type) and multidrug-resistant (Ad1000) SW620 colon…”
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Structure of the human genomic glutathione S-transferase-pi gene by Morrow, C S, Cowan, K H, Goldsmith, M E

“…The complete human genomic glutathione-S-transferase-pi gene (GST-pi) was isolated from a lambda Charon 4A bacteriophage library which was screened by…”
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Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human α class glutathione S-transferase gene by LEYLAND-JONES, B. R, TOWNSEND, A. J, TU, C.-P. D, COWAN, K. H, GOLDSMITH, M. E

“…Studies have suggested that the alpha class glutathione S-transferase (GST) may protect cells from the chemotherapeutic drugs chlorambucil and melphalan. In…”
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Isolation of the Human Anionic Glutathione S-Transferase cDNA and the Relation of Its Gene Expression to Estrogen-Receptor Content in Primary Breast Cancer by Moscow, Jeffrey A., Townsend, Alan J., Goldsmith, Merrill E., Whang-Peng, Jacqueline, Vickers, Philip J., Poisson, Roger, Legault-Poisson, Sandra, Myers, Charles E., Cowan, Kenneth H.

“…The development of multidrug resistance in MCF7 human breast cancer cells is associated with overexpression of P-glycoprotein, changes in activities of several…”
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A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene by GOLDSMITH, M. E, MADDEN, M. J, MORROW, C. S, COWAN, K. H

“…Basal transcription of the human multidrug resistance (mdr1) promoter was studied by chloramphenicol acetyltransferase (CAT) reporter fusion gene analysis in…”
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Release of a globin gene enriched chromatin fraction from chicken erythrocyte nuclei following DNase II digestion by Goldsmith, M E

“…Mild digestion of chicken erythrocyte nuclei with deoxyribonuclease II results in the release of a chromatin fraction which is 4- to 13-fold enriched for the…”
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Silent'' Nucleotide Substitution in a β+-thalassemia Globin Gene Activates Splice Site in Coding Sequence RNA by Goldsmith, Merrill E., Humphries, R. Keith, Ley, Timothy, Cline, Amanda, Kantor, Judith A., Nienhuis, Arthur W.

“…A β+-thalassemia globin gene was isolated from the genome of a Black individual by molecular cloning. DNA sequence analysis revealed only a single difference…”
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5′ Nucleotide Sequences Influence Serum-Modulated Expression of a Human Dihydrofolate Reductase Minigene by Goldsmith, Merrill E., Beckman, Carolyn A., Cowan, Kenneth H.

“…Human dihydrofolate reductase (DHFR) gene sequences were isolated from DHFR gene-amplified breast cancer cell line MCF-7. These genomic sequences plus human…”
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