Search Results - "Goldsmith, K T"

E1A RNA transcripts amplify adenovirus-mediated tumor reduction by Dion, L D, Goldsmith, K T, Strong, T V, Bilbao, G, Curiel, D T, Garver, Jr, R I

“…Previous work by this group has established that E1-defective, recombinant adenoviruses can be replication-enabled by the codelivery of a plasmid encoding the…”
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Modulation of bFGF in lung fibroblasts by TGF-beta and PDGF by Goldsmith, K T, Gammon, R B, Garver, Jr, R I

“…Growth factors produced by alveolar macrophages are thought to promote the fibroblast proliferation within interstitial spaces of fibrotic lungs. This study…”
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Serum response heterogeneity among nonsmall cell lung cancer cell lines by Goldsmith, KT, Listinsky, CM, Garver, RI, Jr

“…This study examined the morphology, in vitro growth, and two genetic responses to serum stimulation in the nonsmall cell lung cancer (NSCLC) cell lines…”
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Transforming growth factor beta within fibrotic scleroderma lungs by Moreland, L W, Goldsmith, K T, Russell, W J, Young, Jr, K R, Garver, Jr, R I

“…Since transforming growth factor beta (TGF beta) has been implicated as an important mediator of pulmonary fibrosis, we measured TGF beta protein and gene…”
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Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity by Pace, C S, Goldsmith, K T

“…The possible role of protein kinase c in regulating the electrical events in the B-cell plasma membrane was examined by using the tumor promoter…”
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Amplification of Recombinant Adenoviral Transgene Products Occurs by Inhibition of Histone Deacetylase by Dion, L.David, Goldsmith, Kelly T., Tang, De-chu, Engler, Jeffrey A., Yoshida, Minoru, Garver, Robert I.

“…n-Butyrate (butyrate) has been shown to amplify transgene expression in cells infected with E1-defective adenoviruses. The present studies were undertaken in…”
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Effect of substitution of a permeable weak acid for the permissive role of glucose in amino acid-induced electrical activity in B-cells by Pace, C S, Goldsmith, K T

“…The amino acids L-leucine, L-isoleucine, and L-arginine require a subthreshold concentration of glucose to elicit insulin release and electrical activity from…”
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Phospholipase C and melittin enhancement of glucose-induced electrical activity by Pace, C S, Goldsmith, K T

“…The influence of exogenous phospholipase C and melittin on electrical activity in islet B cells was determined to assess the extent to which…”
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trans E1 component requirements for maximal replication of E1-defective recombinant adenovirus by Goldsmith, K T, Dion, L D, Curiel, D T, Garver, Jr, R I

“…Strategies that enable E1-defective recombinant adenoviruses to selectively undergo replication in neoplastic tissue may be useful for future investigations or…”
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Strategy for achieving selective killing of carcinomas by Garver, Jr, R I, Goldsmith, K T, Rodu, B, Hu, P C, Sorscher, E J, Curiel, D T

“…Carcinomas are malignancies derived from epithelial cells that frequently respond poorly to conventional chemotherapy. Selective expression or transduction of…”
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Surfactant protein A-directed toxin gene kills lung cancer cells in vitro by Smith, M J, Rousculp, M D, Goldsmith, K T, Curiel, D T, Garver, Jr, R I

“…Human surfactant protein A (SPA) expression is considered a marker of respiratory epithelial differentiation. Non-small cell lung cancers (NSCLC) are…”
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Quantitative and in vivo activity of adenoviral-producing cells made by cotransduction of a replication-defective adenovirus and a replication-enabling plasmid by Dion, L D, Goldsmith, K T, Garver, Jr, R I

“…Achieving limited recombinant viral replication may provide a means of amplifying viral-mediated gene transfer in vivo. We have previously shown that…”
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Trans complementation of an E1A-deleted adenovirus with codelivered E1A sequences to make recombinant adenoviral producer cells by Goldsmith, K T, Curiel, D T, Engler, J A, Garver, Jr, R I

“…Replication-incompetent adenovirus is conventionally produced by cells that supply replication-enabling proteins from viral sequences present in trans. As an…”
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Quantitative evaluation of retroviral gene transduction efficiency in human lung cancer cells by Rousculp, M D, Goldsmith, K T, Garver, Jr, R I

“…Gene therapy may serve as a valuable therapeutic modality for malignancies, such as lung cancer, that are poorly responsive to conventional therapies. Although…”
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