Search Results - "Goldsmith, David R"

Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions by Miller, Brian J, Goldsmith, David R

“…The evidence to date, coupled with advances in immunology and genetics has afforded the field an unparalleled opportunity to investigate the hypothesis that a…”
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Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology by Goldsmith, David R., Bekhbat, Mandakh, Mehta, Neeti D., Felger, Jennifer C.

“…Findings from numerous laboratories and across neuroimaging modalities have consistently shown that exogenous administration of cytokines or inflammatory…”
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Inflammation and Negative Symptoms of Schizophrenia: Implications for Reward Processing and Motivational Deficits by Goldsmith, David R, Rapaport, Mark Hyman

“…Negative symptoms of schizophrenia are debilitating and chronic in nature, are difficult to treat, and contribute to poor functional outcomes. Motivational…”
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Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression by Haroon, Ebrahim, Welle, James R, Woolwine, Bobbi J, Goldsmith, David R, Baer, Wendy, Patel, Trusharth, Felger, Jennifer C, Miller, Andrew H

“…Kynurenine pathway (KP) metabolites are believed to be a link between inflammation and depression through effects on brain glutamate receptors. However,…”
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Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications by Lucido, Michael J, Bekhbat, Mandy, Goldsmith, David R, Treadway, Michael T, Haroon, Ebrahim, Felger, Jennifer C, Miller, Andrew H

“…Exogenous administration of inflammatory stimuli to humans and laboratory animals and chronic endogenous inflammatory states lead to motivational deficits and…”
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Prenatal exposure to viral infection and neuropsychiatric disorders in offspring: A review of the literature and recommendations for the COVID-19 pandemic by Zimmer, Anna, Youngblood, Alix, Adnane, Adam, Miller, Brian J., Goldsmith, David R.

“…•Viral pandemics have been associated with an increased incidence of schizophrenia.•Maternal immune activation models have provided support for this…”
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Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion by Ellis, Justin K, Walker, Elaine F, Goldsmith, David R

“…First episode psychosis (FEP), and subsequent diagnosis of schizophrenia or schizoaffective disorder, predominantly occurs during late adolescence, is…”
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Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review by Rootes-Murdy, Kelly, Goldsmith, David R, Turner, Jessica A

“…Delusions are marked, fixed beliefs that are incongruent with reality. Delusions, with comorbid hallucinations, are a hallmark of certain psychotic disorders…”
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Neural Correlates of Social Cooperation and Non-Cooperation as a Function of Psychopathy by Rilling, James K, Glenn, Andrea L, Jairam, Meeta R, Pagnoni, Giuseppe, Goldsmith, David R, Elfenbein, Hanie A, Lilienfeld, Scott O

“…Background Psychopathy is a disorder involving a failure to experience many emotions that are necessary for appropriate social behavior. In this study, we…”
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The neural correlates of the affective response to unreciprocated cooperation by Rilling, James K., Goldsmith, David R., Glenn, Andrea L., Jairam, Meeta R., Elfenbein, Hanie A., Dagenais, Julien E., Murdock, Christina D., Pagnoni, Giuseppe

“…Humans excel at reciprocal altruism in which two individuals exchange altruistic acts to their mutual advantage. The evolutionary stability of this system…”
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Social cognitive neural networks during in-group and out-group interactions by Rilling, James K., Dagenais, Julien E., Goldsmith, David R., Glenn, Andrea L., Pagnoni, Giuseppe

“…Several functionally connected networks of activity have now been identified in the resting human brain that may be amplified or attenuated by specific…”
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Suicide Prevention in Schizophrenia: Do Long-Acting Injectable Antipsychotics (LAIs) have a Role? by Pompili, Maurizio, Orsolini, Laura, Lamis, Dorian A, Goldsmith, David R, Nardella, Adele, Falcone, Giulia, Corigliano, Valentina, Luciano, Mario, Fiorillo, Andrea

“…Suicide risk is a major cause of death among patients with schizophrenia. Death by suicide has been reported in approximately 5% of schizophrenia patients…”
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Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects by Pearce, Bradley D, Massa, Nicholas, Goldsmith, David R, Gandhi, Zeal H, Hankus, Allison, Alrohaibani, Alaaeddin, Goel, Neha, Cuthbert, Bruce, Fargotstein, Molly, Barr, Dana Boyd, Panuwet, Parinya, Brown, Victoria M, Duncan, Erica

“…Chronic infection with (TOXO) results in microcysts in the brain that are controlled by inflammatory activation and subsequent changes in the kynurenine…”
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The psychoneuroimmunology of Psychosis: Peeking past the clouds of Heterogeneity: Editorial by Upthegrove, Rachel, Goldsmith, David R.

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Where there’s smoke, there’s fire: Cannabis, P2RX7 and inflammatory pathways intersect to increase psychosis susceptibility by Goldsmith, David R.

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What does plasma CRP tell us about peripheral and central inflammation in depression? by Felger, Jennifer C., Haroon, Ebrahim, Patel, Trusharth A., Goldsmith, David R., Wommack, Evanthia C., Woolwine, Bobbi J., Le, Ngoc-Anh, Feinberg, Rachel, Tansey, Malu G., Miller, Andrew H.

“…Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients…”
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Predictors of successful anti-inflammatory drug trials in patients with schizophrenia: A meta-regression and critical commentary by Chandra, Anjali, Miller, Brian J., Goldsmith, David R.

“…•Anti-inflammatories have potential benefit in patients with schizophrenia.•This meta-analysis investigated potential predictors of successful trials.•Small…”
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Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder by Haroon, Ebrahim, Daguanno, Alexander W., Woolwine, Bobbi J., Goldsmith, David R., Baer, Wendy M., Wommack, Evanthia C., Felger, Jennifer C., Miller, Andrew H.

“…•Antidepressant treatment trials were measured in the current episode of depression.•Patients with multiple failed treatment trials had increased inflammatory…”
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TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia by Goldsmith, David R., Haroon, Ebrahim, Miller, Andrew H., Strauss, Gregory P., Buckley, Peter F., Miller, Brian J.

“…Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is…”
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Schizophrenia: A scientific graveyard or a pragmatically useful diagnostic construct? by Walker, Elaine F., Goldsmith, David R.

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