Search Results - "Goldshmidt, O."

Heparanase induces tissue factor expression in vascular endothelial and cancer cells by NADIR, Y., BRENNER, B., ZETSER, A., ILAN, N., SHAFAT, I., ZCHARIA, E., GOLDSHMIDT, O., VLODAVSKY, I.

“…Background: Over‐expression of tissue factor (TF) and activation of the coagulation system are common in cancer patients. Heparanase is an…”
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Heparanase expression during normal liver development and following partial hepatectomy by Goldshmidt, Orit, Yeikilis, Rita, Mawasi, Nidal, Paizi, Melia, Gan, Noga, Ilan, Neta, Pappo, Orit, Vlodavsky, Israel, Spira, Gadi

“…Heparan sulphate proteoglycans are major components of the liver extracellular matrix. Their cleavage by heparanase (endo‐β‐glucuronidase) may thus be involved…”
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Heparanase neutralizes the anticoagulation properties of heparin and low‐molecular‐weight heparin by NASSER, N. J., SARIG, G., BRENNER, B., NEVO, E., GOLDSHMIDT, O., ZCHARIA, E., LI, J. P., VLODAVSKY, I.

“…Background: Heparanase is a mammalian endo‐D‐glucuronidase that cleaves heparan sulfate (HS) in the extracellular matrix and cell surface. It is preferentially…”
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Multitoroidal Interconnects For Tightly Coupled Supercomputers by Aridor, Y., Domany, T., Goldshmidt, O., Kliteynik, Y., Shmueli, E., Moreira, J.E.

“…The processing elements of many modern tightly coupled multicomputers are connected via mesh or toroidal networks. Such interconnects are simple and highly…”
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Involvement of heparanase in tumor progression and normal differentiation by Vlodavsky, I, Zcharia, E, Goldshmidt, O, Eshel, R, Katz, B-Z, Minucci, S, Kovalchuk, O, Penco, S, Pisano, C, Naggi, A, Casu, B

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Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development by Vlodavsky, Israel, Goldshmidt, Orit, Zcharia, Eyal, Atzmon, Ruth, Rangini-Guatta, Zehava, Elkin, Michael, Peretz, Tamar, Friedmann, Yael

“…Cleavage of heparan sulphate proteoglycans (HSPGs) affects the integrity and functional state of tissues and thereby fundamental normal and pathological…”
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Human Heparanase Is Localized within Lysosomes in a Stable Form by Goldshmidt, O

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Cell Surface Expression and Secretion of Heparanase Markedly Promote Tumor Angiogenesis and Metastasis by Goldshmidt, Orit, Zcharia, Eyal, Abramovitch, Rinat, Metzger, Shula, Aingorn, Helena, Friedmann, Yael, Schirrmacher, Volker, Mitrani, Eduardo, Vlodavsky, Israel

“…The present study emphasizes the importance of cell surface expression and secretion of heparanase (endo-β-D-glucuronidase) in tumor angiogenesis and…”
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Human heparanase nuclear localization and enzymatic activity by Schubert, Shay Y, Ilan, Neta, Shushy, Moran, Ben-Izhak, Ofer, Vlodavsky, Israel, Goldshmidt, Orit

“…In previous studies, we have demonstrated that human heparanase (endo-β-D-glucuronidase) is localized primarily in a perinuclear pattern within lysosomes and…”
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Properties and function of heparanase in cancer metastasis and angiogenesis by Vlodavsky, I, Goldshmidt, O

“…Cleavage of heparan sulfate proteoglycans affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena…”
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Eosinophil major basic protein: first identified natural heparanase-inhibiting protein by Temkin, Vladislav, Aingorn, Helena, Puxeddu, Ilaria, Goldshmidt, Orit, Zcharia, Eyal, Gleich, Gerald J, Vlodavsky, Israel, Levi-Schaffer, Francesca

“…Heparanase and eosinophils are involved in several diseases, including inflammation, cancer, and angiogenesis. We sought to determine whether eosinophils…”
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Human Heparanase Is Localized within Lysosomes in a Stable Form by Goldshmidt, Orit, Nadav, Liat, Aingorn, Helena, Irit, Cohen, Feinstein, Naomi, Ilan, Neta, Zamir, Eli, Geiger, Benjamin, Vlodavsky, Israel, Katz, Ben-Zion

“…Heparanase is an endo-β- d-glucuronidase involved in degradation of heparan sulfate (HS) and extracellular matrix (ECM) of a wide range of cells of vertebrate…”
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Expression Pattern and Secretion of Human and Chicken Heparanase Are Determined by Their Signal Peptide Sequence by Goldshmidt, O, Zcharia, E, Aingorn, H, Guatta-Rangini, Z, Atzmon, R, Michal, I, Pecker, I, Mitrani, E, Vlodavsky, I

“…Cleavage of heparan sulfate (HS) proteoglycans affects the integrity and function of tissues and thereby fundamental phenomena, involving cell migration and…”
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Heparanase improves mouse embryo implantation by Revel, Ariel, Helman, Aharon, Koler, Moriah, Shushan, Asher, Goldshmidt, Orit, Zcharia, Eyal, Aingorn, Helena, Vlodavsky, Israel

“…To improve mouse embryonic implantation by recombinant heparanase supplementation. Heparanase, an endoglycosidase-degrading heparan sulfate proteoglycan, may…”
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Time-dependent fluorescent H2 emission by Goldshmidt, O., Sternberg, A.

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Molecular properties and involvement of heparanase in cancer progression and normal development by Vlodavsky, Israel, Goldshmidt, Orit, Zcharia, Eyal, Metzger, Shula, Chajek-Shaul, Tova, Atzmon, Ruth, Guatta-Rangini, Zehava, Friedmann, Yael

“…Heparan sulfate proteoglycans (HSPGs) play a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular…”
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Heparanase enhances early hepatocyte inclusion in the recipient liver after transplantation in partially hepatectomized rats by Tsiperson, Vladislav, Goldshmidt, Orit, Ilan, Neta, Shoshany, Gideon, Vlodavsky, Israel, Veitsman, Ella, Baruch, Yaacov

“…Hepatocyte transplantation is an emerging approach for the treatment of liver diseases. However, broad clinical application of this method has been limited by…”
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The Role of Heparanase in Lymph Node Metastatic Dissemination: Dynamic Contrast-Enhanced MRI of Eb Lymphoma in Mice by Dafni, Hagit, Cohen, Batya, Ziv, Keren, Israely, Tomer, Goldshmidt, Orit, Nevo, Nava, Harmelin, Alon, Vlodavsky, Israel, Neeman, Michal

“…Heparanase expression has been linked to increased tumor invasion, metastasis, angiogenesis and with poor prognosis. The aim of the study was to monitor the…”
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Association of hereditary hemorrhagic telangiectasia and hereditary nonpolyposis colorectal cancer in the same kindred by Goldschmidt, Neta, Metzger, Shulamit, Wexler, Isaiah D., Goldshmidt, Orit, Hershcovici, Tiberiu, Chajek‐Shaul, Tova

“…Endoglin (CD105) is a proliferation‐associated protein that is strongly expressed in endothelial tissue and has a role in tumor angiogenesis. Mutations in…”
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The effect of heparanase on hepatocyte engraftment after intrasplenic cell transplantation in the rats by Tsiperson, V., Ilan, N., Shoshany, G., Goldshmidt, O., Vlodavsky, I., Baruch, Y.

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