Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium

Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium

Phenotypic manipulation of allograft endothelium to reduce immunogenicity would have a significant impact on transplantation. In this study we have demonstrated that random seeding of a heart allograft with endothelium, of host origin, not only promotes long-term survival, but reduces the requiremen...

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Bibliographic Details
Published in:The Journal of thoracic and cardiovascular surgery Vol. 109; no. 5; pp. 905 - 909
Main Authors: Quigley, R.L., Switzer, S.S., Victor, T.A., Goldschmidt, R.A., Salinger, M.H., Arentzen, C.E., Alexander, J.C., Anderson, R.W.
Format: Journal Article
Language:English
Published: Philadelphia, PA Mosby, Inc 01-05-1995
AATS/WTSA
Elsevier
Subjects:
Animals
Biological and medical sciences
Endothelium - immunology
Heart Transplantation - methods
Immunosuppression - methods
Lymphocyte Culture Test, Mixed
Medical sciences
Myocardium - immunology
Phenotype
Random Allocation
Rats
Rats, Inbred BN
Rats, Inbred Lew
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Tissue Survival
Transplantation, Heterotopic
Transplantation, Homologous
Heart
Endothelial cell
Rat
Rodentia
Transplantation
Heterotransplantation
Seeding
Survival
Vertebrata
Mammalia
Treatment
Donor
Surgery
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Description
Summary:Phenotypic manipulation of allograft endothelium to reduce immunogenicity would have a significant impact on transplantation. In this study we have demonstrated that random seeding of a heart allograft with endothelium, of host origin, not only promotes long-term survival, but reduces the requirement for pharmacologic immunosuppression. We propose that this simple technology could easily be extrapolated to the clinical arena where hypothermia and preservation solutions have allowed allografts to remain ex vivo for extended periods. (J T HORAC C ARDIOVASC S URG 1995;109:905-9)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(95)70315-2