Search Results - "Goldring, Chris"

Assessing the Safety of Stem Cell Therapeutics by Goldring, Chris E.P., Duffy, Paul A., Benvenisty, Nissim, Andrews, Peter W., Ben-David, Uri, Eakins, Rowena, French, Neil, Hanley, Neil A., Kelly, Lorna, Kitteringham, Neil R., Kurth, Jens, Ladenheim, Deborah, Laverty, Hugh, McBlane, James, Narayanan, Gopalan, Patel, Sara, Reinhardt, Jens, Rossi, Annamaria, Sharpe, Michaela, Park, B. Kevin

“…Unprecedented developments in stem cell research herald a new era of hope and expectation for novel therapies. However, they also present a major challenge for…”
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Managing the challenge of chemically reactive metabolites in drug development by Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A

“…Key Points Metabolism of drugs can generate metabolites that are chemically reactive towards cellular molecules and have the potential to alter biological…”
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Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile by Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.

“…The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This…”
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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy by Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin

“…Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is…”
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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study by Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, Houdt, Jos van, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus

“…Abstract Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH…”
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Stem cell models as an in vitro model for predictive toxicology by Lynch, Stephen, Pridgeon, Chris S, Duckworth, Carrie A, Sharma, Parveen, Park, B Kevin, Goldring, Chris E P

“…Adverse drug reactions (ADRs) are the unintended side effects of drugs. They are categorised as either predictable or unpredictable drug-induced injury and may…”
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Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes by Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T, Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A, Mohamet, Lisa, Best, Marie, Fenwick, Stephen W, Malik, Hassan, Kitteringham, Neil R, Goldring, Chris E, Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A

“…Graphical abstract…”
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Circulating microRNAs as potential markers of human drug‐induced liver injury by Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin

“…New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched…”
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Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury by Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P, Rehman, Adeeb H, Goldring, Chris E P, Naisbitt, Dean J, Meng, Xiaoli

“…Abstract Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 is…”
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Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells by Kratschmar, Denise V, Calabrese, Diego, Walsh, Jo, Lister, Adam, Birk, Julia, Appenzeller-Herzog, Christian, Moulin, Pierre, Goldring, Chris E, Odermatt, Alex

“…Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in…”
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Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System by Ogese, Monday O., Jenkins, Rosalind E., Adair, Kareena, Tailor, Arun, Meng, Xiaoli, Faulkner, Lee, Enyindah, Bright O., Schofield, Amy, Diaz‐Nieto, Rafael, Ressel, Lorenzo, Eagle, Gina L., Kitteringham, Neil R., Goldring, Chris E., Park, B. Kevin, Naisbitt, Dean J., Betts, Catherine

“…Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse reaction with complex pathomechanisms. However, it is now evident…”
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Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet? by Kia, Richard, Sison, Rowena L. C., Heslop, James, Kitteringham, Neil R., Hanley, Neil, Mills, John S., Park, B. Kevin, Goldring, Chris E. P.

“…Amongst the different types of adverse drug reactions, drug‐induced liver injury is the most prominent cause of patient morbidity and mortality. However, the…”
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Proteome‐wide analyses of human hepatocytes during differentiation and dedifferentiation by Rowe, Cliff, Gerrard, Dave T., Jenkins, Roz, Berry, Andrew, Durkin, Kesta, Sundstrom, Lars, Goldring, Chris E., Park, B. Kevin, Kitteringham, Neil R., Hanley, Karen Piper, Hanley, Neil A.

“…Failure to predict hepatotoxic drugs in preclinical testing makes it imperative to develop better liver models with a stable phenotype in culture. Stem…”
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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms by Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.

“…The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new…”
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Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways by Quinn, Leonard M., Haldenby, Sam, Antzcak, Philip, Fowler, Anna, Bullock, Katie, Kenny, John, Gilbert, Timothy, Andrews, Timothy, Diaz-Nieto, Rafael, Fenwick, Stephen, Jones, Robert, Costello-Goldring, Eithne, Poston, Graeme, Greenhalf, William, Palmer, Daniel, Malik, Hassan, Goldring, Chris

“…Peri-hilar cholangiocarcinoma (pCCA) is chemorefractory and limited genomic analyses have been undertaken in Western idiopathic disease. We undertook…”
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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity by Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin

“…Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether…”
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In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells by Pridgeon, Chris S, Forootan, Shiva Seyed, Zhang, Fang, Harper, Nicholas, Palmer, Daniel, Weightmann, Richard, Gregory, Sian, Hewitt, Zoe, Baker, Duncan, Halliwell, Jason, Moore, Harry, Ricci, Emanuele, Andrews, Peter W, Poptani, Harish, Hay, David C, Park, B Kevin, Goldring, Chris E P

“…Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they…”
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MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity by Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L C, Zhang, Fang, Pridgeon, Chris S, Heslop, James A, Metcalfe, Pete, Kitteringham, Neil R, Baxter, Melissa, Harrison, Sean, Hanley, Neil A, Burke, Zoë D, Storm, Mike P, Welham, Melanie J, Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J, Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W, Malik, Hassan, Goldring, Chris E P, Park, B Kevin

“…Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex…”
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MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans by Hornby, Robert James, Starkey Lewis, Philip, Dear, James, Goldring, Chris, Park, B Kevin

“…Drug-induced liver injury (DILI) is a common form of adverse drug reaction seen within the clinic. Sensitive, specific and non-invasive biomarkers of liver…”
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Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies by Scarfe, Lauren, Brillant, Nathalie, Kumar, J. Dinesh, Ali, Noura, Alrumayh, Ahmed, Amali, Mohammed, Barbellion, Stephane, Jones, Vendula, Niemeijer, Marije, Potdevin, Sophie, Roussignol, Gautier, Vaganov, Anatoly, Barbaric, Ivana, Barrow, Michael, Burton, Neal C., Connell, John, Dazzi, Francesco, Edsbagge, Josefina, French, Neil S., Holder, Julie, Hutchinson, Claire, Jones, David R., Kalber, Tammy, Lovatt, Cerys, Lythgoe, Mark F., Patel, Sara, Patrick, P. Stephen, Piner, Jacqueline, Reinhardt, Jens, Ricci, Emanuelle, Sidaway, James, Stacey, Glyn N., Starkey Lewis, Philip J., Sullivan, Gareth, Taylor, Arthur, Wilm, Bettina, Poptani, Harish, Murray, Patricia, Goldring, Chris E. P., Park, B. Kevin

“…Regenerative medicine therapies hold enormous potential for a variety of currently incurable conditions with high unmet clinical need. Most progress in this…”
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