Search Results - "Goldman, Steven"

Glymphatic failure as a final common pathway to dementia by Nedergaard, Maiken, Goldman, Steven A

“…Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and…”
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Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking by Goldman, Steven A.

“…A variety of neurological disorders are attractive targets for stem and progenitor cell-based therapy. Yet many conditions are not, whether by virtue of an…”
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How to make an oligodendrocyte by Goldman, Steven A, Kuypers, Nicholas J

“…Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction of electrical impulses along axons. Oligodendrocyte loss results in…”
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Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination by Wang, Su, Bates, Janna, Li, Xiaojie, Schanz, Steven, Chandler-Militello, Devin, Levine, Corri, Maherali, Nimet, Studer, Lorenz, Hochedlinger, Konrad, Windrem, Martha, Goldman, Steven A.

“…Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of the congenitally dysmyelinated brain. To establish a potential…”
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Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice by Han, Xiaoning, Chen, Michael, Wang, Fushun, Windrem, Martha, Wang, Su, Shanz, Steven, Xu, Qiwu, Oberheim, Nancy Ann, Bekar, Lane, Betstadt, Sarah, Silva, Alcino J., Takano, Takahiro, Goldman, Steven A., Nedergaard, Maiken

“…Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution…”
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Glial evolution as a determinant of human behavior and its disorders by Goldman, Steven A.

“…Astroglial complexity and pleomorphism have increased significantly with hominid evolution. This suggests a potential association between glial evolution and…”
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Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier by Lou, Nanhong, Takano, Takahiro, Pei, Yong, Xavier, Anna L., Goldman, Steven A., Nedergaard, Maiken

“…Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular…”
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Implications of the discovery of brain lymphatic pathways by Iliff, Jeffrey J, Goldman, Steven A, Nedergaard, Maiken

“…The lymphatic system performs essential physiological functions for protein homeostasis and immune surveillance; hence, the apparent absence of conventional…”
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Perivascular instruction of cell genesis and fate in the adult brain by Goldman, Steven A, Chen, Zhuoxun

“…The perivascular niche for neurogenesis was first reported as the co-association of newly generated neurons and their progenitors with both dividing and…”
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Glial cells in schizophrenia: a unified hypothesis by Dietz, Andrea G, Goldman, Steven A, Nedergaard, Maiken

“…The cellular neurobiology of schizophrenia remains poorly understood. We discuss neuroimaging studies, pathological findings, and experimental work supporting…”
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SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions by Sun, Wei, Cornwell, Adam, Li, Jiashu, Peng, Sisi, Osorio, M Joana, Aalling, Nadia, Wang, Su, Benraiss, Abdellatif, Lou, Nanhong, Goldman, Steven A, Nedergaard, Maiken

“…Astrocytes have in recent years become the focus of intense experimental interest, yet markers for their definitive identification remain both scarce and…”
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Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2 by Eyler, Christine E., Wu, Qiulian, Yan, Kenneth, MacSwords, Jennifer M., Chandler-Militello, Devin, Misuraca, Katherine L., Lathia, Justin D., Forrester, Michael T., Lee, Jeongwu, Stamler, Jonathan S., Goldman, Steven A., Bredel, Markus, McLendon, Roger E., Sloan, Andrew E., Hjelmeland, Anita B., Rich, Jeremy N.

“…Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this…”
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Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease by Khakh, Baljit S, Beaumont, Vahri, Cachope, Roger, Munoz-Sanjuan, Ignacio, Goldman, Steven A, Grantyn, Rosemarie

“…Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and…”
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Progenitor cell-based treatment of glial disease by Goldman, Steven A

“…Diseases of glia, including astrocytes and oligodendrocytes, are among the most prevalent and disabling, yet least appreciated, conditions in neurology. In…”
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Glia Disease and Repair-Remyelination by Franklin, Robin J M, Goldman, Steven A

“…The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology…”
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Glial Progenitor Cell-Based Treatment and Modeling of Neurological Disease by Goldman, Steven A., Nedergaard, Maiken, Windrem, Martha S.

“…The diseases of myelin are among the most prevalent and disabling conditions in neurology. These diseases include both the vascular and inflammatory…”
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Use of differentiated pluripotent stem cells as replacement therapy for treating disease by Fox, Ira J., Daley, George Q., Goldman, Steven A., Huard, Johnny, Kamp, Timothy J., Trucco, Massimo

“…Challenges for stem cell–based therapies Patient-derived pluripotent stem cells (PSCs) hold promise in the treatment of injury and disease. An ever-increasing…”
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Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys by Goldman, Steven A

“…Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved…”
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Astrocytic contributions to Huntington's disease pathophysiology by Khakh, Baljit S., Goldman, Steven A.

“…Huntington's disease (HD) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine‐encoding CAG expansion in the…”
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The wind speeds, dust content, and mass-loss rates of evolved AGB and RSG stars at varying metallicity by Goldman, Steven R, van Loon, Jacco Th, Zijlstra, Albert A, Green, James A, Wood, Peter R, Nanni, Ambra, Imai, Hiroshi, Whitelock, Patricia A, Matsuura, Mikako, Groenewegen, Martin A T, Gomez, Jose F

“…We present the results of our survey of 1612-MHz circumstellar OH maser emission from asymptotic giant branch (AGB) stars and red supergiants (RSGs) in the…”
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