Search Results - "Goldman, Aaron D."

Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix by Borlee, Bradley R, Goldman, Aaron D, Murakami, Keiji, Samudrala, Ram, Wozniak, Daniel J, Parsek, Matthew R

“…Pseudomonas aeruginosa, the principal pathogen of cystic fibrosis patients, forms antibiotic-resistant biofilms promoting chronic colonization of the airways…”
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Scaling laws in enzyme function reveal a new kind of biochemical universality by Gagler, Dylan C, Karas, Bradley, Kempes, Christopher P, Malloy, John, Mierzejewski, Veronica, Goldman, Aaron D, Kim, Hyunju, Walker, Sara I

“…All life on Earth is unified by its use of a shared set of component chemical compounds and reactions, providing a detailed model for universal biochemistry…”
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A consensus view of the proteome of the last universal common ancestor by Crapitto, Andrew J., Campbell, Amy, Harris, AJ, Goldman, Aaron D.

“…The availability of genomic and proteomic data from across the tree of life has made it possible to infer features of the genome and proteome of the last…”
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Cofactors are Remnants of Life’s Origin and Early Evolution by Goldman, Aaron D., Kacar, Betul

“…The RNA World is one of the most widely accepted hypotheses explaining the origin of the genetic system used by all organisms today. It proposes that the…”
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How did life become cellular? by Goldman, Aaron D

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A New View of the Last Universal Common Ancestor by Goldman, Aaron D., Becerra, Arturo

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Introduction to the Special Issue on Early Evolution and the Last Common Ancestor by Becerra, Arturo, Goldman, Aaron D.

“…The early evolution of life spans an extensive period preceding the emergence of the first eukaryotic cell. This epoch, which transpired from 4.5 to 2.5…”
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Very early evolution from the perspective of microbial ecology by Goldman, Aaron D., Kaçar, Betül

“…The universal ancestor at the root of the species tree of life depicts a population of organisms with a surprising degree of complexity, posessing genomes and…”
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The very early evolution of biological complexity by Goldman, Aaron D., Fournier, Gregory P.

“…All extant life is descended from a common ancestor, which, despite being very ancient, appears to have been a complex cellular organism. A new study by Moody…”
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The evolution and functional repertoire of translation proteins following the origin of life by Goldman, Aaron D, Samudrala, Ram, Baross, John A

“…The RNA world hypothesis posits that the earliest genetic system consisted of informational RNA molecules that directed the synthesis of modestly functional…”
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Evolution of Cellular Organization Along the First Branches of the Tree of Life by Kailing, Freya, Lieberman, Jules, Wang, Joshua, Turner, Joshua L., Goldman, Aaron D.

“…Current evidence suggests that some form of cellular organization arose well before the time of the last universal common ancestor (LUCA). Standard…”
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Electron transport chains as a window into the earliest stages of evolution by Goldman, Aaron D, Weber, Jessica M, LaRowe, Douglas E, Barge, Laura M

“…The origin and early evolution of life is generally studied under two different paradigms: bottom up and top down. Prebiotic chemistry and early Earth…”
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Comprehensive computational analysis of Hmd enzymes and paralogs in methanogenic Archaea by Goldman, Aaron D, Leigh, John A, Samudrala, Ram

“…Methanogenesis is the sole means of energy production in methanogenic Archaea. H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) catalyzes a step…”
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Informatic Capabilities of Translation and Its Implications for the Origins of Life by Cuevas-Zuviría, Bruno, Adam, Zachary R., Goldman, Aaron D., Kaçar, Betül

“…The ability to encode and convert heritable information into molecular function is a defining feature of life as we know it. The conversion of information into…”
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The Journal of Molecular Evolution Turns 50 by Goldman, Aaron D., Liberles, David A.

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The Coevolution of Cellularity and Metabolism Following the Origin of Life by Takagi, Yuta A., Nguyen, Diep H., Wexler, Tom B., Goldman, Aaron D.

“…The emergence of cellular organisms occurred sometime between the origin of life and the evolution of the last universal common ancestor and represents one of…”
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Nucleobases in Meteorites to Nucleobases in RNA and DNA? by Krishnamurthy, Ramanarayanan, Goldman, Aaron D., Liberles, David A., Rogers, Karyn L., Tor, Yitzhak

“…Nucleic acids likely played a foundational role in the origin of life. However, the prebiotic chemistry of nucleoside and nucleotide synthesis has proved…”
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Testing Abiotic Reduction of NAD + Directly Mediated by Iron/Sulfur Minerals by Weber, Jessica M, Henderson, Bryana L, LaRowe, Douglas E, Goldman, Aaron D, Perl, Scott M, Billings, Keith, Barge, Laura M

“…Life emerged in a geochemical context, possibly in the midst of mineral substrates. However, it is not known to what extent minerals and dissolved inorganic…”
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Reactivity of Metabolic Intermediates and Cofactor Stability under Model Early Earth Conditions by Maltais, Thora R., VanderVelde, David, LaRowe, Douglas E., Goldman, Aaron D., Barge, Laura M.

“…Understanding the emergence of metabolic pathways is key to unraveling the factors that promoted the origin of life. One popular view is that protein cofactors…”
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The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes by Swart, Estienne C, Bracht, John R, Magrini, Vincent, Minx, Patrick, Chen, Xiao, Zhou, Yi, Khurana, Jaspreet S, Goldman, Aaron D, Nowacki, Mariusz, Schotanus, Klaas, Jung, Seolkyoung, Fulton, Robert S, Ly, Amy, McGrath, Sean, Haub, Kevin, Wiggins, Jessica L, Storton, Donna, Matese, John C, Parsons, Lance, Chang, Wei-Jen, Bowen, Michael S, Stover, Nicholas A, Jones, Thomas A, Eddy, Sean R, Herrick, Glenn A, Doak, Thomas G, Wilson, Richard K, Mardis, Elaine R, Landweber, Laura F

“…The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic variation…”
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