Search Results - "Goldie, Kenneth N."

Focus: The interface between data collection and data processing in cryo-EM by Biyani, Nikhil, Righetto, Ricardo D., McLeod, Robert, Caujolle-Bert, Daniel, Castano-Diez, Daniel, Goldie, Kenneth N., Stahlberg, Henning

“…We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing…”
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Structure of the T4 baseplate and its function in triggering sheath contraction by Taylor, Nicholas M. I., Prokhorov, Nikolai S., Guerrero-Ferreira, Ricardo C., Shneider, Mikhail M., Browning, Christopher, Goldie, Kenneth N., Stahlberg, Henning, Leiman, Petr G.

“…Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to…”
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Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction by Gruene, Tim, Wennmacher, Julian T. C., Zaubitzer, Christan, Holstein, Julian J., Heidler, Jonas, Fecteau‐Lefebvre, Ariane, De Carlo, Sacha, Müller, Elisabeth, Goldie, Kenneth N., Regeni, Irene, Li, Teng, Santiso‐Quinones, Gustavo, Steinfeld, Gunther, Handschin, Stephan, van Genderen, Eric, van Bokhoven, Jeroen A., Clever, Guido H., Pantelic, Radosav

“…Chemists of all fields currently publish about 50 000 crystal structures per year, the vast majority of which are X‐ray structures. We determined two molecular…”
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Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts by Arnold, Stefan A., Albiez, Stefan, Bieri, Andrej, Syntychaki, Anastasia, Adaixo, Ricardo, McLeod, Robert A., Goldie, Kenneth N., Stahlberg, Henning, Braun, Thomas

“…We present a sample preparation method for cryo-electron microscopy (cryo-EM) that requires only 3–20nL of sample to prepare a cryo-EM grid, depending on the…”
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Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography by Klena, Nikolai, Le Guennec, Maeva, Tassin, Anne‐Marie, van den Hoek, Hugo, Erdmann, Philipp S, Schaffer, Miroslava, Geimer, Stefan, Aeschlimann, Gabriel, Kovacik, Lubomir, Sadian, Yashar, Goldie, Kenneth N, Stahlberg, Henning, Engel, Benjamin D, Hamel, Virginie, Guichard, Paul

“…Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role…”
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A helical inner scaffold provides a structural basis for centriole cohesion by Le Guennec, Maeva, Klena, Nikolai, Gambarotto, Davide, Laporte, Marine H, Tassin, Anne-Marie, van den Hoek, Hugo, Erdmann, Philipp S, Schaffer, Miroslava, Kovacik, Lubomir, Borgers, Susanne, Goldie, Kenneth N, Stahlberg, Henning, Bornens, Michel, Azimzadeh, Juliette, Engel, Benjamin D, Hamel, Virginie, Guichard, Paul

“…The ninefold radial arrangement of microtubule triplets (MTTs) is the hallmark of the centriole, a conserved organelle crucial for the formation of centrosomes…”
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Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation by Leppänen, Veli-Matti, Tvorogov, Denis, Kisko, Kaisa, Prota, Andrea E., Jeltsch, Michael, Anisimov, Andrey, Markovic-Mueller, Sandra, Stuttfeld, Edward, Goldie, Kenneth N., Ballmer-Hofer, Kurt, Alitalo, Kari

“…Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in…”
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Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin by Piper, Sarah J, Brillault, Lou, Rothnagel, Rosalba, Croll, Tristan I, Box, Joseph K, Chassagnon, Irene, Scherer, Sebastian, Goldie, Kenneth N, Jones, Sandra A, Schepers, Femke, Hartley-Tassell, Lauren, Ve, Thomas, Busby, Jason N, Dalziel, Julie E, Lott, J Shaun, Hankamer, Ben, Stahlberg, Henning, Hurst, Mark R H, Landsberg, Michael J

“…ABC toxins are pore-forming virulence factors produced by pathogenic bacteria. YenTcA is the pore-forming and membrane binding A subunit of the ABC toxin…”
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outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis by Chen, Yu-Yen, Peng, Benjamin, Yang, Qiaohui, Glew, Michelle D, Veith, Paul D, Cross, Keith J, Goldie, Kenneth N, Chen, Dina, O'Brien-Simpson, Neil, Dashper, Stuart G, Reynolds, Eric C

“…Protein substrates of a novel secretion system of Porphyromonas gingivalis contain a conserved C-terminal domain (CTD) essential for secretion and attachment…”
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Dissecting the 3-D structure of vimentin intermediate filaments by cryo-electron tomography by Goldie, Kenneth N., Wedig, Tatjana, Mitra, Alok K., Aebi, Ueli, Herrmann, Harald, Hoenger, Andreas

“…Vimentin polymerizes via complex lateral interactions of coiled-coil dimers into long, flexible filaments referred to as intermediate filaments (IFs)…”
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Cryo‐EM reconstruction of Type VI secretion system baseplate and sheath distal end by Nazarov, Sergey, Schneider, Johannes P, Brackmann, Maximilian, Goldie, Kenneth N, Stahlberg, Henning, Basler, Marek

“…The bacterial Type VI secretion system (T6SS) assembles from three major parts: a membrane complex that spans inner and outer membranes, a baseplate, and a…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Deuterium induces a distinctive Escherichia coli proteome that correlates with the reduction in growth rate by Opitz, Christian, Ahrné, Erik, Goldie, Kenneth N., Schmidt, Alexander, Grzesiek, Stephan

“…Substitution of protium (H) for deuterium (D) strongly affects biological systems. Whereas higher eukaryotes such as plants and mammals hardly survive a…”
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Assembly of Poly(dopamine) Films Mixed with a Nonionic Polymer by Zhang, Yan, Thingholm, Bo, Goldie, Kenneth N, Ogaki, Ryosuke, Städler, Brigitte

“…Poly(dopamine) (PDA) coatings have recently attracted considerable interest for a variety of applications. Here, we investigate the film deposition of dopamine…”
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Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A by Markovic-Mueller, Sandra, Stuttfeld, Edward, Asthana, Mayanka, Weinert, Tobias, Bliven, Spencer, Goldie, Kenneth N., Kisko, Kaisa, Capitani, Guido, Ballmer-Hofer, Kurt

“…Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases: VEGFR-1, -2,…”
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Structural rearrangements in tubulin following microtubule formation by Krebs, Angelika, Goldie, Kenneth N, Hoenger, Andreas

“…Microtubules are essential cytoskeletal structures that mediate several dynamic processes in a cell. To shed light on the structural processes relating to…”
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Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome by Cavadini, Simone, Fischer, Eric S., Bunker, Richard D., Potenza, Alessandro, Lingaraju, Gondichatnahalli M., Goldie, Kenneth N., Mohamed, Weaam I., Faty, Mahamadou, Petzold, Georg, Beckwith, Rohan E. J., Tichkule, Ritesh B., Hassiepen, Ulrich, Abdulrahman, Wassim, Pantelic, Radosav S., Matsumoto, Syota, Sugasawa, Kaoru, Stahlberg, Henning, Thomä, Nicolas H.

“…The cullin–RING ubiquitin E3 ligase (CRL) family comprises over 200 members in humans. The COP9 signalosome complex (CSN) regulates CRLs by removing their…”
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Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopy by Stoffler, Daniel, Goldie, Kenneth N, Feja, Bernhard, Aebi, Ueli

“…Nuclear pore complexes (NPCs) are large macromolecular assemblies embedded in the double membrane nuclear envelope. They are the major gateways mediating…”
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Confined Multiple Enzymatic (Cascade) Reactions within Poly(dopamine)-based Capsosomes by Hosta-Rigau, Leticia, York-Duran, Maria J, Zhang, Yan, Goldie, Kenneth N, Städler, Brigitte

“…The design of compartmentalized carriers as artificial cells is envisioned to be an efficient tool with potential applications in the biomedical field. The…”
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Morphofunctional changes at the active zone during synaptic vesicle exocytosis by Radecke, Julika, Seeger, Raphaela, Kádková, Anna, Laugks, Ulrike, Khosrozadeh, Amin, Goldie, Kenneth N, Lučić, Vladan, Sørensen, Jakob B, Zuber, Benoît

“…Synaptic vesicle (SV) fusion with the plasma membrane (PM) proceeds through intermediate steps that remain poorly resolved. The effect of persistent high or…”
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