Search Results - "Goldie, James H."

Drug resistance in cancer: a perspective by Goldie, J H

“…Drug resistance remains the thorniest obstacle in developing improved systemic therapies for disseminated cancer. The combination of genetic instability…”
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Eradication of Human Non-Hodgkin’s Lymphoma in SCID Mice by BCL-2 Antisense Oligonucleotides Combined with Low-Dose Cyclophosphamide by KLASA, R. J, BALLY, M. B, NG, R, GOLDIE, J. H, GASCOYNE, R. D, WONG, F. M. P

“…Cancers overexpressing Bcl-2 protein, which prevents programmed cell death (apoptosis), are less sensitive to stresses that produce cellular damage, including…”
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The genetic origin of drug resistance in neoplasms: implications for systemic therapy by GOLDIE, J. H, COLDMAN, A. J

“…Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic…”
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A Literature Review of Single Agent Treatment of Multiply Relapsed Aggressive Non-Hodgkin's Lymphoma by Webb, Murray S., Saltman, David L., Connors, Joseph M., Goldie, James H.

“…To analyze the available literature describing the treatment of relapsed aggressive non-Hodgkin's lymphoma (NHL) with single-agent chemotherapies, several…”
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Gas-chromatographic analysis of busulfan for therapeutic drug monitoring by EMBREE, L, BURNS, R. B, HEGGIE, J. R, PHILLIPS, G. L, REECE, D. E, SPINELLI, J. J, HARTLEY, D. O, HUDON, N. J, GOLDIE, J. H

“…The development and validation of a gas chromatographic assay method for determination of total and free busulfan concentrations in human plasma for…”
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Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line by DEDHAR, S, GOLDIE, J. H

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Adjuvant Therapy for Breast Cancer by Müller, H J, Gleiter, C H, Gundert-Remy, U

“…To the Editor: Wood et al. (May 5 issue) 1 report the results of a randomized study of different doses and levels of dose intensity (dose per unit of time) of…”
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Drug resistance in cancer: A perspective: Molecular and Physiologic Mechanisms of Drug Resistance in Cancer by GOLDIE, James H

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Extended-range linear magnetostrictive motor with double-sided three-phase stators by Won-Jong Kim, Goldie, J.H., Gerver, M.J., Kiley, J.E., Swenbeck, J.R.

“…The authors have developed a novel extended-range linear magnetostrictive motor using the peristaltic motion of a laminated Terfenol-D (Tb/sub 0.3/Dy/sub…”
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Modelling the process of drug resistance by Goldie, J H

“…Modelling the process of drug resistance can provide insight into such issues as the difference between intrinsic and acquired drug resistance. Other important…”
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Arguments supporting the concept of non-cross-resistant combinations of chemotherapy by Goldie, J H

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Toxicity studies in thymidine kinase-deficient herpes simplex virus therapy for malignant astrocytoma by JIA, W. W. G, TAN, J, REDEKOP, G. J, GOLDIE, J. H

“…Previous studies have shown that genetically engineered thymidine kinase (tk)-defective herpes simplex virus type 1 (HSV-1) can effectively and selectively…”
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Chromatographic analysis and pharmacokinetics of liposome-encapsulated doxorubicin in non-small-cell lung cancer patients by Embree, L, Gelmon, K A, Lohr, A, Mayer, L D, Coldman, A J, Cullis, P R, Palaitis, W, Pilkiewicz, F, Hudon, N J, Heggie, J R

“…A sensitive and specific quantitative assay for total doxorubicin concentrations in plasma containing liposome-encapsulated doxorubicin hydrochloride (TLC…”
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High Torque Multi-Air Gap Electric Motors by Goldie, James H.

“…SatCon Technology Corporation has developed a new configuration for the induction machine which offers higher torque densities and a more advantageous…”
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Extended-range linear magnetostrictive motor with double-sided three-phase stators by Won-Jong Kim, Goldie, J.H., Gerver, M.J., Kiley, J., Swenbeck, J.R.

“…We have developed a novel extended-range linear magnetostrictive motor using the peristaltic motion of a laminated Terfenol-D (Tb/sub 0.3/Dy/sub 0.7/Fe/sub 2/)…”
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Mathematical models of drug resistance and chemotherapy effects by Goldie, J H

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Drug resistance and cancer chemotherapy strategy in breast cancer by Goldie, J H

“…Evidence exists that spontaneous mutations to drug resistance are a major obstacle to chemotherapeutic cure in both experimental and clinical neoplasms…”
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Treatment of recurrent and metastatic head and neck cancer with cisplatin/etoposide/bleomycin by Osoba, D, Band, P R, Connors, J M, Goldie, J H, Knowling, M A, Fetherstonhaugh, E M

“…Cisplatin/etoposide/bleomycin (DEB) was given as an outpatient regimen in a novel weekly schedule to 27 patients with recurrent and/or widely metastatic cancer…”
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Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity by Dedhar, S, Goldie, J H

“…Dihydrofolate reductase from a MTX-resistant human promyelocytic leukemia cell line (HL-60 R4-29) had previously been found to have a higher specific activity…”
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Algebraic dual-energy thermal analysis with application to variable reluctance motor design by Tolikas, M., Goldie, J.H., Lang, J.H., Kirtley, J.L.

“…The algebraic dual-energy method has been successfully employed in the calculation of static resistances, capacitances and inductances, yielding fast and…”
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